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Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ.
Xiao C, Wu Q, Xie Y, Tan J, Ding Y, Bai L.
Food Funct. 2018 Dec 13;9(12):6495-6507. doi: 10.1039/c8fo01656a.

Hypoglicemic and Hypolipedimic Effects of Ganoderma lucidum in Streptozotocin-Induced Diabetic Rats.
Bach EE, Hi EMB, Martins AMC, Nascimento PAM, Wadt NSY.
Medicines (Basel). 2018 Jul 28;5(3). pii: E78. doi: 10.3390/medicines5030078.

Isolation, Structural Elucidation, and α-Glucosidase Inhibitory Activities of Triterpenoid Lactones and Their Relevant Biogenetic Constituents from Ganoderma resinaceum.
Chen XQ, Lin LG, Zhao J, Chen LX, Tang YP, Luo DL, Li SP.
Molecules. 2018 Jun 8;23(6). pii: E1391. doi: 10.3390/molecules23061391.

Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
J Clin Med. 2018 Jun 15;7(6). pii: E152. doi: 10.3390/jcm7060152.

Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice.
Liang D, Yong T, Chen S, Xie Y, Chen D, Zhou X, Li D, Li M, Su L, Zuo D.
Int J Mol Sci. 2018 May 7;19(5). pii: E1394. doi: 10.3390/ijms19051394.

Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.
Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595. eCollection 2018.

Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.
Chen XQ, Zhao J, Chen LX, Wang SF, Wang Y, Li SP.
Phytochemistry. 2018 May;149:103-115. doi: 10.1016/j.phytochem.2018.01.007. Epub 2018 Feb 25.

Hypoglycemic mechanism of a novel proteoglycan, extracted from Ganoderma lucidum, in hepatocytes.
Yang Z, Chen C, Zhao J, Xu W, He Y, Yang H, Zhou P.
Eur J Pharmacol. 2018 Feb 5;820:77-85. doi: 10.1016/j.ejphar.2017.12.020. Epub 2017 Dec 9.

A novel PTP1B inhibitor extracted from Ganoderma lucidum ameliorates insulin resistance by regulating IRS1-GLUT4 cascades in the insulin signaling pathway.
Yang Z, Wu F, He Y, Zhang Q, Zhang Y, Zhou G, Yang H, Zhou P.
Food Funct. 2018 Jan 24;9(1):397-406. doi: 10.1039/c7fo01489a.
 
Enzyme inhibitory, Antifungal, Antibacterial and hemolytic potential of various fractions of Colebrookia oppositifolia.
Riaz T, Abbasi MA, Rehman A, Siddiqui SZ, Shahid M, Fatima H, Ashraf M, Ejaz SA, Rasool ZG, Abbasi GH.
Pak J Pharm Sci. 2017 Jan;30(1):105-112.

Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.
Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N.
World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. Review.

Enzymatic System of Antioxidant Protection of Erythrocytes in Diabetic Rats Treated with Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Agaricomycetes).
Vitak TY, Wasser SP, Nevo E, Sybirna NO.
Int J Med Mushrooms. 2017;19(8):697-708. doi: 10.1615/IntJMedMushrooms.2017021305.

Functional Properties of Partially Characterized Polysaccharide from the Medicinal Mushroom Ganoderma neo-japonicum (Agaricomycetes).
Subramaniam S, Raman J, Sabaratnam V, Heng CK, Kuppusamy UR.
Int J Med Mushrooms. 2017;19(10):849-859. doi: 10.1615/IntJMedMushrooms.2017024355.

Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors.
Amen Y, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Shimizu K.
J Nat Med. 2017 Apr;71(2):380-388. doi: 10.1007/s11418-016-1069-y. Epub 2017 Jan 10.

Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice.
Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J.
J Ethnopharmacol. 2017 Jan 20;196:47-57. doi: 10.1016/j.jep.2016.11.044. Epub 2016 Nov 27.

A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Aymice.
Wang K, Bao L, Ma K, Zhang J, Chen B, Han J, Ren J, Luo H, Liu H.
Eur J Med Chem. 2017 Feb 15;127:1035-1046. doi: 10.1016/j.ejmech.2016.11.015. Epub 2016 Nov 9.

Comparison of the Chemical Profiles and Antioxidant and Antidiabetic Activities of Extracts from Two Ganoderma Species (Agaricomycetes).
Tang X, Cai W, Xu B.
Int J Med Mushrooms. 2016;18(7):609-20.

A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome.
Klupp NL, Kiat H, Bensoussan A, Steiner GZ, Chang DH.
Sci Rep. 2016 Aug 11;6:29540. doi: 10.1038/srep29540.

A Polysaccharide from Ganoderma atrum Improves Liver Function in Type 2 Diabetic Rats via Antioxidant Action and Short-Chain Fatty Acids Excretion.
Zhu KX, Nie SP, Tan LH, Li C, Gong DM, Xie MY.
J Agric Food Chem. 2016 Mar 9;64(9):1938-44. doi: 10.1021/acs.jafc.5b06103. Epub 2016 Feb 29.

Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice.
Li K, Yu M, Hu Y, Ren G, Zang T, Xu X, Qu J.
Chem Biol Interact. 2016 Mar 5;247:30-8. doi: 10.1016/j.cbi.2016.01.013. Epub 2016 Jan 27.

Bioconversion of ginsenosides in the american ginseng ( xī yáng shēn) extraction residue by fermentation with lingzhi ( líng zhī, ganoderma lucidum).
Yang Hsu B, Hui Chen C, Jang Lu T, Sun Hwang L.
J Tradit Complement Med. 2013 Apr;3(2):95-101. doi: 10.4103/2225-4110.110416.

Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors.
Fatmawati S, Kondo R, Shimizu K.
Bioorg Med Chem Lett. 2013 Nov 1;23(21):5900-3. doi: 10.1016/j.bmcl.2013.08.084. Epub 2013 Sep 5.

Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.
Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. doi: 10.1002/14651858.CD007259.pub2.

Modulatory effect of crude aqueous extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes), on hematological and antioxidant indices in Plasmodium berghei-infected mice.
Oluba OM, Adebisi KE, Eidangbe GO, Odutuga AA, Onyeneke EC.
Int J Med Mushrooms. 2014;16(5):499-506.

Isolation and characterization of a hyperbranched proteoglycan from Ganoderma lucidum for anti-diabetes.
Pan D, Wang L, Chen C, Hu B, Zhou P.
Carbohydr Polym. 2015 Mar 6;117:106-14. doi: 10.1016/j.carbpol.2014.09.051. Epub 2014 Sep 28.

[Role of phytotherapy in the prevention and treatment of obesity]
Balázs A.
Orv Hetil. 2010 May 9;151(19):763-73.

[Effect of Ganoderma lucidum polysaccharides on hemodynamic and antioxidation in T2DM rats]
Xue H, Qiao J, Meng G, Wu F, Luo J, Chen H, Zheng H, Xu J.
Zhongguo Zhong Yao Za Zhi. 2010 Feb;35(3):339-43.

HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression.
Yang Q, Wang S, Xie Y, Sun J, Wang J.
Int J Biol Macromol. 2010 Mar 1;46(2):167-72.

Ganoderma lucidum: a potent pharmacological macrofungus.
Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS.
Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.

Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW.
Phytomedicine. 2009 May;16(5):426-36.

Comparison of vanadium-rich activity of three species fungi of basidiomycetes.
Han C, Cui B, Qu J.
Biol Trace Elem Res. 2009 Mar;127(3):278-83.

A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium.
Han C, Liu T.
Biol Trace Elem Res. 2009 Feb;127(2):177-82.

[Intervention effect of ganoderma lucidum spores on the changes of XOD, MPO and SDH in the testis tissue of NIDDM rats]
Wang SQ, Qin WB, Kang YM, Ma XR, Liu L, Liu JX, Zhang T, Zhang B, Liang YF, Wang FF.
Zhonghua Nan Ke Xue. 2008 Sep;14(9):792-5.

Cordyceps: a traditional Chinese medicine and another fungal therapeutic biofactory?
Paterson RR.
Phytochemistry. 2008 May;69(7):1469-95.

Effects of fermentation products of Ganoderma lucidum on growth performance and immunocompetence in weanling pigs.
Chen SD, Hsieh MC, Chiou MT, Lai YS, Cheng YH.
Arch Anim Nutr. 2008 Feb;62(1):22-32.

Ganodermataceae: natural products and their related pharmacological functions.
Zhou X, Lin J, Yin Y, Zhao J, Sun X, Tang K.
Am J Chin Med. 2007;35(4):559-74.

Potential of a novel polysaccharide preparation (GLPP) from Anhui-grown Ganoderma lucidum in tumor treatment and immunostimulation.
Pang X, Chen Z, Gao X, Liu W, Slavin M, Yao W, Yu LL.
J Food Sci. 2007 Aug;72(6):S435-42.

Application of proteomics in Chinese medicine research.
Cho WC.
Am J Chin Med. 2007;35(6):911-22.

Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats.
Yang BK, Jung YS, Song CH.
Phytother Res. 2007 Nov;21(11):1066-9.

[Effects of ganoderma lucidum spores on mitochondrial calcium ion and cytochrome C in epididymal cells of type 2 diabetes rats]
Ma XR, Zhou CF, Wang SQ, Wang WQ, Liu YX, Wang SX, Wang FF, Zhang JH, Li YY.
Zhonghua Nan Ke Xue. 2007 May;13(5):400-2.

[The pharmacological study of Ganoderma spores and their active components]
Lin ZB, Wang PY.
Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):541-7.

Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats.
Ni T, Hu Y, Sun L, Chen X, Zhong J, Ma H, Lin Z.
Int J Mol Med. 2007 Jul;20(1):45-51

[Effects of ganoderma lucidum spores on cytochrome C and mitochondrial calcium in the testis of NIDDM rats]
Wang BX, Wang SQ, Qin WB, Wang SX, Ma XR, Zhang T.
Zhonghua Nan Ke Xue. 2006 Dec;12(12):1072-5.

Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice.
He CY, Li WD, Guo SX, Lin SQ, Lin ZB.
J Asian Nat Prod Res. 2006 Dec;8(8):705-11.

Inhibitory effects of Ganoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues.
Jung SH, Lee YS, Shim SH, Lee S, Shin KH, Kim JS, Kim YS, Kang SS.
Phytother Res. 2005 Jun;19(6):477-80.

A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia.
Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S.
J Med Food. 2005 Spring;8(1):53-8.

Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components.
Huie CW, Di X.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5;812(1-2):241-57.

Effect of medicinal plant extracts on forced swimming capacity in mice.
Jung K, Kim IH, Han D.
J Ethnopharmacol. 2004 Jul;93(1):75-81.

Hypoglycemic effect of Ganoderma lucidum polysaccharides.
Zhang HN, Lin ZB.
Acta Pharmacol Sin. 2004 Feb;25(2):191-5.

In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage.
Zhang HN, He JH, Yuan L, Lin ZB.
Life Sci. 2003 Sep 19;73(18):2307-19.

Structural features of immunologically active polysaccharides from Ganoderma lucidum.
Bao XF, Wang XS, Dong Q, Fang JN, Li XY.
Phytochemistry. 2002 Jan;59(2):175-81.

Ling-Zhi-8: a fungal protein with immunomodulatory effects.
van der Hem LG, van der Vliet JA, Kino K, Hoitsma AJ, Tax WJ.
Transplant Proc. 1996 Apr;28(2):958-9.

Ling Zhi-8: studies of a new immunomodulating agent.
van der Hem LG, van der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJ.
Transplantation. 1995 Sep 15;60(5):438-43.

Prolongation of allograft survival with Ling Zhi-8, a new immunosuppressive drug.
van der Hem LG, van der Vliet JA, Bocken CF, Kino K, Hoitsma AJ, Tax WJ.
Transplant Proc. 1994 Apr;26(2):746.

Medicinal benefits of the mushroom Ganoderma.
Jong SC, Birmingham JM.
Adv Appl Microbiol. 1992;37:101-34.

An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice.
Kino K, Mizumoto K, Sone T, Yamaji T, Watanabe J, Yamashita A, Yamaoka K, Shimizu K, Ko K, Tsunoo H.
Diabetologia. 1990 Dec;33(12):713-8.

Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
Hikino H, Ishiyama M, Suzuki Y, Konno C.
Planta Med. 1989 Oct;55(5):423-8.

Hypoglycemic actions of some heteroglycans of Ganoderma lucidum fruit bodies.
Hikino H, Mizuno T.
Planta Med. 1989 Aug;55(4):385.

Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidium.
Kino K, Yamashita A, Yamaoka K, Watanabe J, Tanaka S, Ko K, Shimizu K, Tsunoo H.
J Biol Chem. 1989 Jan 5;264(1):472-8.

Effects of the extracts of Ganoderma lucidum on blood glucose level in rats.
Kimura Y, Okuda H, Arichi S.
Planta Med. 1988 Aug;54(4):290-4.

Isolation and Hypoglycemic Activity of Ganoderans A and B, Glycans of Ganoderma lucidum Fruit Bodies1.
Hikino H, Konno C, Mirin Y, Hayashi T.
Planta Med. 1985 Aug;51(4):339-40.

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