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Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.
Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.
Nutrients. 2020 Dec 24;13(1):38. doi: 10.3390/nu13010038.

Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis.
Qiao S, Bao L, Wang K, Sun S, Liao M, Liu C, Zhou N, Ma K, Zhang Y, Chen Y, Liu SJ, Liu H.
Cell Rep. 2020 Aug 11;32(6):108005. doi: 10.1016/j.celrep.2020.108005.

Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum.
Yuan S, Pan Y, Zhang Z, He Y, Teng Y, Liang H, Wu X, Yang H, Zhou P.
Biol Pharm Bull. 2020 Oct 1;43(10):1542-1550. doi: 10.1248/bpb.b20-00358. Epub 2020 Aug 5.

Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet.
Guo WL , Guo JB , Liu BY , Lu JQ , Chen M , Liu B , Bai WD , Rao PF , Ni L , Lv XC .
Food Funct. 2020 Aug 1;11(8):6818-6833. doi: 10.1039/d0fo00436g. Epub 2020 Jul 20.

Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study.
Hassan HM, Al-Wahaibi LH, Elmorsy MA, Mahran YF.
Drug Des Devel Ther. 2020 Jun 11;14:2335-2353. doi: 10.2147/DDDT.S249093. eCollection 2020.

Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl(4)-induced hepatotoxicity.
Song X, Cui W, Gao Z, Zhang J, Jia L.
Int Immunopharmacol. 2021 Mar 31;96:107554. doi: 10.1016/j.intimp.2021.107554. Online ahead of print.

Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice.
Zhang Y, Feng Y, Wang W, Jia L, Zhang J.
Oxid Med Cell Longev. 2021 Feb 3;2021:9703682. doi: 10.1155/2021/9703682. eCollection 2021.

The protective effects of the Ganoderma atrum polysaccharide against acrylamide-induced inflammation and oxidative damage in rats.
Jiang G, Lei A, Chen Y, Yu Q, Xie J, Yang Y, Yuan T, Su D.
Food Funct. 2021 Jan 7;12(1):397-407. doi: 10.1039/d0fo01873b. Epub 2020 Dec 18.

High-Pressure Supercritical CO(2) Extracts of Ganoderma lucidum Fruiting Body and Their Anti-hepatoma Effect Associated With the Ras/Raf/MEK/ERK Signaling Pathway.
Zhu L, Wu M, Li P, Zhou Y, Zhong J, Zhang Z, Li Y, Yao W, Xu J.
Front Pharmacol. 2020 Dec 14;11:602702. doi: 10.3389/fphar.2020.602702. eCollection 2020.

Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M.
Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.

Pancreatic cancer cell apoptosis is induced by a proteoglycan extracted from Ganoderma lucidum.
Wu X, Jiang L, Zhang Z, He Y, Teng Y, Li J, Yuan S, Pan Y, Liang H, Yang H, Zhou P.
Oncol Lett. 2021 Jan;21(1):34. doi: 10.3892/ol.2020.12295. Epub 2020 Nov 12.

The Novel Herbal Cocktail AGA Alleviates Oral Cancer through Inducing Apoptosis, Inhibited Migration and Promotion of Cell Cycle Arrest at SubG1 Phase.
Lu JH, Chou YR, Deng YH, Huang MS, Chien ST, Quynh BTN, Wu CY, Peláez Achtmann EA, Cheng HC, Dubey NK, Deng WP.
Cancers (Basel). 2020 Oct 31;12(11):3214. doi: 10.3390/cancers12113214.

Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.

Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, Chen J, Li L, Jia Y, Liu M, Zhou F.
J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.
Oluwafemi Adetuyi B, Olamide Okeowo T, Adefunke Adetuyi O, Abraham Adebisi O, Ogunlana OO, Janet Oretade O, Marraiki N, Beshbishy AM, N Welson N, Batiha GE.
Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313.

Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice.
Lee SJ, Lee DH, Kim HW.
Cell Rep. 2020 Aug 11;32(6):108005. doi: 10.1016/j.celrep.2020.108005.

Changes and roles of intestinal fungal microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease.
Xu J, Zhang Y, Wang X, Ren X, Liu Y.
Am J Transl Res. 2020 Jul 15;12(7):3445-3460. eCollection 2020.

Structurally diverse lanostane triterpenoids from medicinal and edible mushroom Ganoderma resinaceum Boud.
Shi QQ, Huang YJ, Su HG, Gao Y, Lu SY, Peng XR, Li XN, Zhou L, Qiu MH.
Bioorg Chem. 2020 Jul;100:103871. doi: 10.1016/j.bioorg.2020.103871. Epub 2020 Apr 22.

Molecule mechanisms of Ganoderma lucidum treated hepatocellular carcinoma based on the transcriptional profiles and miRNA-target network.
Tang C, Zhao R, Ni H, Zhao K, He Y, Fang S, Chen Q.
Biomed Pharmacother. 2020 May;125:110028. doi: 10.1016/j.biopha.2020.110028. Epub 2020 Feb 25.

Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits.
Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW.
Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020.

Bioactivities and Molecular Characterizations of the Polysaccharide(s) from Ultrasonic-Circulating Extracts of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).
Chen TQ, Kan YJ, Yang C, Wu JG, Wu JZ.
Int J Med Mushrooms. 2020;22(5):455-466. doi: 10.1615/IntJMedMushrooms.2020034227.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury.
Qiu Z, Zhong D, Yang B.
Adv Exp Med Biol. 2019;1182:217-242. doi: 10.1007/978-981-32-9421-9_9. Review.

Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen's egg test for analysis of micronucleus induction.
Çelik B, Özparlak H.
Biotech Histochem. 2019 Nov;94(8):628-636. doi: 10.1080/10520295.2019.1622784. Epub 2019 Jul 8.

Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y.
Liang C, Tian D, Liu Y, Li H, Zhu J, Li M, Xin M, Xia J.
Eur J Med Chem. 2019 Jul 15;174:130-141. doi: 10.1016/j.ejmech.2019.04.039. Epub 2019 Apr 20. Review.

Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.
Li HN, Zhao LL, Zhou DY, Chen DQ.
Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth.
Das A, Alshareef M, Henderson F Jr, Martinez Santos JL, Vandergrift WA 3rd, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D.
Clin Transl Oncol. 2019 Nov 15. doi: 10.1007/s12094-019-02240-6. [Epub ahead of print]

The ameliorations of Ganoderma applanatum residue polysaccharides against CCl4 induced liver injury.
Gao Z, Yuan F, Li H, Feng Y, Zhang Y, Zhang C, Zhang J, Song Z, Jia L.
Int J Biol Macromol. 2019 Sep 15;137:1130-1140. doi: 10.1016/j.ijbiomac.2019.07.044. Epub 2019 Jul 8.

Improved antitumor activity of cisplatin combined with Ganoderma lucidum polysaccharides in U14 cervical carcinoma-bearing mice.
Zhu J, Xu J, Jiang LL, Huang JQ, Yan JY, Chen YW, Yang Q.
Kaohsiung J Med Sci. 2019 Apr;35(4):222-229. doi: 10.1002/kjm2.12020. Epub 2019 Apr 8.

Effects of sporoderm-broken spores of Ganoderma lucidum on growth performance, antioxidant function and immune response of broilers.
Liu T, Zhou J, Li W, Rong X, Gao Y, Zhao L, Fan Y, Zhang J, Ji C, Ma Q.
Anim Nutr. 2020 Mar;6(1):39-46. doi: 10.1016/j.aninu.2019.11.005. Epub 2019 Dec 23.

Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice.
Susilo RJK, Winarni D, Husen SA, Hayaza S, Punnapayak H, Wahyuningsih SPA, Sajidah ES, Darmanto W.
Vet World. 2019 Dec;12(12):1987-1991. doi: 10.14202/vetworld.2019.1987-1991. Epub 2019 Dec 17.

Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases.
Geng X, Zhong D, Su L, Lin Z, Yang B.
Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20.

Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters.
Tong AJ, Hu RK, Wu LX, Lv XC, Li X, Zhao LN, Liu B.
J Food Biochem. 2020 Jan;44(1):e13109. doi: 10.1111/jfbc.13109. Epub 2019 Dec 3.

Antioxidative and Free Radical Scavenging Activity of Ganoderma (Lingzhi).
Lin Z, Deng A.
Adv Exp Med Biol. 2019;1182:271-297. doi: 10.1007/978-981-32-9421-9_12. Review.

Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury.
Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X.
Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24.

Production of triterpenoid compounds from Ganoderma lucidum spore powder using ultrasound-assisted extraction.
Shen SF, Zhu LF, Wu Z, Wang G, Ahmad Z, Chang MW.
Prep Biochem Biotechnol. 2020;50(3):302-315. doi: 10.1080/10826068.2019.1692218. Epub 2019 Nov 22.

Preparation of Ganoderma lucidum polysaccharide‑chromium (III) complex and its hypoglycemic and hypolipidemic activities in high-fat and high-fructose diet-induced pre-diabetic mice.
Li L, Xu JX, Cao YJ, Lin YC, Guo WL, Liu JY, Bai WD, Zhang YY, Ni L, Liu B, Rao PF, Lv XC.
Int J Biol Macromol. 2019 Nov 1;140:782-793. doi: 10.1016/j.ijbiomac.2019.08.072. Epub 2019 Aug 8.

Protective Function of Novel Fungal Immunomodulatory Proteins Fip-lti1 and Fip-lti2 from Lentinus tigrinus in Concanavalin A-Induced Liver Oxidative Injury.
Gao Y, Wáng Y, Wāng Y, Wu Y, Chen H, Yang R, Bao D.
Oxid Med Cell Longev. 2019 May 6;2019:3139689. doi: 10.1155/2019/3139689. eCollection 2019.

Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
Xu Y, Zhang X, Yan XH, Zhang JL, Wang LY, Xue H, Jiang GC, Ma XT, Liu XJ.
Int J Biol Macromol. 2019 Aug 15;135:706-716. doi: 10.1016/j.ijbiomac.2019.05.166. Epub 2019 May 23.

[Pharmacokinetics of ganoderic acids].
Zhang FF, Liu RM.
Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):905-911. doi: 10.19540/j.cnki.cjcmm.20181213.002. Review. Chinese. 

Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.
Oluba OM.
Lipids Health Dis. 2019 Jan 12;18(1):12. doi: 10.1186/s12944-018-0951-x.

Lanostane-type triterpenoids from the fruiting bodies of Ganoderma applanatum.
Peng X, Li L, Dong J, Lu S, Lu J, Li X, Zhou L, Qiu M.
Phytochemistry. 2019 Jan;157:103-110. doi: 10.1016/j.phytochem.2018.10.011. Epub 2018 Nov 1.

Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia.
Henao SLD, Urrego SA, Cano AM, Higuita EA.
Int J Med Mushrooms. 2018;20(8):705-716. doi: 10.1615/IntJMedMushrooms.2018026986.
 
The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network.
Zhao R, Chen Q, He YM.
Sci Rep. 2018 Aug 23;8(1):12680. doi: 10.1038/s41598-018-30881-0.
 
Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
J Clin Med. 2018 Jun 15;7(6). pii: E152. doi: 10.3390/jcm7060152.
 
Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats.
Guo WL, Pan YY, Li L, Li TT, Liu B, Lv XC.
Food Funct. 2018 Jun 20;9(6):3419-3431. doi: 10.1039/c8fo00836a.
 
Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice.
Fan S, Huang X, Wang S, Li C, Zhang Z, Xie M, Nie S.
Food Chem Toxicol. 2018 Sep;119:66-72. doi: 10.1016/j.fct.2018.05.027. Epub 2018 May 16.
 
Racemic meroterpenoids from Ganoderma cochlear.
Peng X, Wang X, Chen L, Yang H, Li L, Lu S, Zhou L, Qiu M.
Fitoterapia. 2018 Jun;127:286-292. doi: 10.1016/j.fitote.2018.03.005. Epub 2018 Mar 11.
 
Evaluation of the Antioxidative and Hypo-cholesterolemic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Ameliorating Cardiovascular Disease.
Rahman MA, Abdullah N, Aminudin N.
Int J Med Mushrooms. 2018;20(10):961-969. doi: 10.1615/IntJMedMushrooms.2018028370.
 
Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats.
Sobowale MT, Ozolua RI, Uwaya DO, Ayinde BA.
Int J Med Mushrooms. 2019;21(2):143-154. doi: 10.1615/IntJMedMushrooms.2019029766.
 
Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.
Li T, Yu H, Song Y, Zhang R, Ge M.
J Trace Elem Med Biol. 2019 Mar;52:118-125. doi: 10.1016/j.jtemb.2018.12.010. Epub 2018 Dec 15.
 
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.
 
Effects of Ganoderma lucidum and ‘Essence of Chicken’ on Physical Fatigue Recovery and Exercise Performance Improvement.
Li H, Chen YJ, Hsu YJ, Wu MF, Chiu CC, Tung YT, Tsai WJ, Huang WC, Huang CC.
Chin J Physiol. 2018 Dec 31;61(6):372-383. doi: 10.4077/CJP.2018.BAH646.
 
Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ.
Xiao C, Wu Q, Xie Y, Tan J, Ding Y, Bai L.
Food Funct. 2018 Dec 13;9(12):6495-6507. doi: 10.1039/c8fo01656a.
 
Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review.
Zhao C, Zhang C, Xing Z, Ahmad Z, Li JS, Chang MW.
Int J Biol Macromol. 2019 Jan;121:1160-1178. doi: 10.1016/j.ijbiomac.2018.10.076. Epub 2018 Oct 18. Review.
 
Meroterpenoids from Ganoderma sinense protect hepatocytes and cardiomyocytes from oxidative stress induced injuries.
Gao S, Zhang P, Zhang C, Bao F, Li H, Chen L.
Fitoterapia. 2018 Nov;131:73-79. doi: 10.1016/j.fitote.2018.10.009. Epub 2018 Oct 9.

Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis.
Zhao C, Fan J, Liu Y, Guo W, Cao H, Xiao J, Wang Y, Liu B.
Food Chem. 2019 Jan 15;271:148-156. doi: 10.1016/j.foodchem.2018.07.115. Epub 2018 Jul 18.

Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.
Zhong D, Xie Z, Huang B, Zhu S, Wang G, Zhou H, Lin S, Lin Z, Yang B.
Cell Physiol Biochem. 2018;49(3):1163-1179. doi: 10.1159/000493297. Epub 2018 Sep 7.
 
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Liang Z, Yuan Z, Li G, Fu F, Shan Y.
J Med Food. 2018 Dec;21(12):1218-1227. doi: 10.1089/jmf.2018.4182. Epub 2018 Sep 5.
 
Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide.
Wu S.
Int J Biol Macromol. 2018 Oct 15;118(Pt B):2001-2005. doi: 10.1016/j.ijbiomac.2018.07.082. Epub 2018 Jul 22.
 
Antioxidant and Hepatoprotective Activities of Crude Polysaccharide Extracts from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), by Ultrasonic-Circulating Extraction.
Chen TQ, Wu JG, Kan YJ, Yang C, Wu YB, Wu JZ.
Int J Med Mushrooms. 2018;20(6):581-593. doi: 10.1615/IntJMedMushrooms.2018026536.
 
The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death.
Liu G, Wang K, Kuang S, Cao R, Bao L, Liu R, Liu H, Sun C.
Cell Death Dis. 2018 Jun 7;9(6):689. doi: 10.1038/s41419-018-0731-6.
 
Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats.
Hossen MS, Billah Prince MM, Tanvir EM, Chowdhury MAZ, Rahman MA, Alam F, Paul S, Saha M, Ali MY, Bhoumik NC, Karim N, Gan SH, Khalil MI.
Evid Based Complement Alternat Med. 2018 May 15;2018:6254929. doi: 10.1155/2018/6254929. eCollection 2018.
 
Hypouricemic Effects of Ganoderma applanatum in Hyperuricemia Mice through OAT1 and GLUT9.
Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D.
Front Pharmacol. 2018 Jan 15;8:996. doi: 10.3389/fphar.2017.00996. eCollection 2017.

Racemic meroterpenoids from Ganoderma cochlear.
Peng X, Wang X, Chen L, Yang H, Li L, Lu S, Zhou L, Qiu M.
Fitoterapia. 2018 Mar 11. pii: S0367-326X(18)30206-5. doi: 10.1016/j.fitote.2018.03.005.

Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice.
Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J.
J Ethnopharmacol. 2017 Jan 20;196:47-57. doi: 10.1016/j.jep.2016.11.044. Epub 2016 Nov 27.

Hypouricemic Effects of <i>Ganoderma applanatum</i> in Hyperuricemia Mice through OAT1 and GLUT9.
Yong T, Chen S, Xie Y, Chen D, Su J, Shuai O, Jiao C, Zuo D.
Front Pharmacol. 2018 Jan 15;8:996. doi: 10.3389/fphar.2017.00996. eCollection 2017.

Ganoderic Acid A Metabolites and Their Metabolic Kinetics.
Cao FR, Feng L, Ye LH, Wang LS, Xiao BX, Tao X, Chang Q.
Front Pharmacol. 2017 Mar 7;8:101. doi: 10.3389/fphar.2017.00101. eCollection 2017.
 
Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.
Chen S, Li X, Yong T, Wang Z, Su J, Jiao C, Xie Y, Yang BB.
Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.

Hypocholesterolemic Properties and Prebiotic Effects of Mexican Ganoderma lucidum in C57BL/6 Mice.
Meneses ME, Martínez-Carrera D, Torres N, Sánchez-Tapia M, Aguilar-López M, Morales P, Sobal M, Bernabé T, Escudero H, Granados-Portillo O, Tovar AR.
PLoS One. 2016 Jul 20;11(7):e0159631. doi: 10.1371/journal.pone.0159631. eCollection 2016 Jul 20.

Ganoderic Acid A Metabolites and Their Metabolic Kinetics.
Cao FR, Feng L, Ye LH, Wang LS, Xiao BX, Tao X, Chang Q.
Front Pharmacol. 2017 Mar 7;8:101. doi: 10.3389/fphar.2017.00101. eCollection 2017 Mar 7.
 
Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet.
Wu YS, Ho SY, Nan FH, Chen SN.
BMC Complement Altern Med. 2016 Dec 3;16(1):500.

Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice.
Wu H, Tang S, Huang Z, Zhou Q, Zhang P, Chen Z.
Int J Med Mushrooms. 2016;18(9):841-850.

Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells.
Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K.
J Nat Med. 2016 Jul;70(3):661-6. doi: 10.1007/s11418-016-0976-2. Epub 2016 Feb 22.

Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes).
Gupta A, Kirar V, Keshri GK, Gola S, Yadav A, Negi PS, Misra K.
Int J Med Mushrooms. 2014;16(4):345-54.

Biological activity of Ganoderma lucidum basidiocarps cultivated on alternative and commercial substrate.
Cilerdžić J, Vukojević J, Stajić M, Stanojković T, Glamočlija J.
J Ethnopharmacol. 2014 Aug 8;155(1):312-9. doi: 10.1016/j.jep.2014.05.036. Epub 2014 May 29.

Screening and isolation for anti-hepatofibrotic components from medicinal mushrooms using TGF-(β1-induced live fibrosis in hepatic stellate cells.
Geng Y, Wang J, Xie M, Lu Z, Xu H, Shi JS, Xu ZH.
Int J Med Mushrooms. 2014;16(6):529-39.

Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.).
Liu YJ, Du JL, Cao LP, Jia R, Shen YJ, Zhao CY, Xu P, Yin GJ.
Int J Med Mushrooms. 2014;16(6):529-39.

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.
Oliveira M, Reis FS, Sousa D, Tavares C, Lima RT, Ferreira IC, dos Santos T, Vasconcelos MH.
Food Funct. 2014 Jul 25;5(7):1389-94. doi: 10.1039/c4fo00258j.

An Immunomodulatory Protein (Ling Zhi-8) from a Ganoderma lucidum Induced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery.
Lin HJ, Chang YS, Lin LH, Haung CF, Wu CY, Ou KL.
Evid Based Complement Alternat Med. 2014;2014:916531. doi: 10.1155/2014/916531. Epub 2014 May 5.

Antihepatoma and liver protective potentials of ganoderma lucidum ( ling zhi) fermented in a medium containing black soybean ( hēi dòu) and astragalus membranaceus ( shēng huáng qí).
Min-Chang G, Wei-Hong T, Zhen X, Jie S.
Evid Based Complement Alternat Med. 2014;2014:182817. doi: 10.1155/2014/182817. Epub 2014 Feb 10.

Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α , Oxidative Stress, and NF- κ B Activation in Ovalbumin-Induced Asthmatic Mice.
Min-Chang G, Wei-Hong T, Zhen X, Jie S.
Evid Based Complement Alternat Med. 2014;2014:182817. doi: 10.1155/2014/182817. Epub 2014 Feb 10.

Hepatoprotective effects of triterpenoids from Ganoderma cochlear.
Peng XR, Liu JQ, Wang CF, Li XY, Shu Y, Zhou L, Qiu MH.
J Nat Prod. 2014 Apr 25;77(4):737-43. doi: 10.1021/np400323u. Epub 2014 Feb 21.

Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice.
Wu YW, Fang HL, Lin WC.
Phytother Res. 2010 Apr;24(4):494-9.    

Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.
Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94.

Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum.
Shang D, Zhang J, Wen L, Li Y, Cui Q.
J Agric Food Chem. 2009 Sep 9;57(17):7737-42.   

Free-radical scavenging and mitochondrial antioxidant activities of Reishi-Ganoderma lucidum (Curt: Fr) P. Karst and Arogyapacha-Trichopus zeylanicus Gaertn extracts.
Cherian E, Sudheesh NP, Janardhanan KK, Patani G.
J Basic Clin Physiol Pharmacol. 2009;20(4):289-307.

Ganoderma lucidum: a potent pharmacological macrofungus.
Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS.
Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.

Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW.
Phytomedicine. 2009 May;16(5):426-36.

Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor.
Wang GJ, Huang YJ, Chen DH, Lin YL.
Phytother Res. 2009 Jun;23(6):833-9. 

[Effect of Ganoderma lucidum polysaccharides on intestinal mucosal immune system in H22 liver cancer bearing mice]
Zhou GQ, Zhao HY, Lu C.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):335-9.

Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor.
Wang GJ, Huang YJ, Chen DH, Lin YL.
Phytother Res. 2009 Jun;23(6):833-9.

Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells.
Chen YK, Kuo YH, Chiang BH, Lo JM, Sheen LY.
J Agric Food Chem. 2009 Jul 8;57(13):5713-9.  

Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.
Weng CJ, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD.
J Agric Food Chem. 2009 Jun 10;57(11):5049-57.  

Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines.
Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP.
J Agric Food Chem. 2009 Apr 22;57(8):3087-93.    

[Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]
Li L, Li T, Wang XJ, Xu JP, Wang SG.
Zhong Yao Cai. 2008 Oct;31(10):1514-8.

Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury.
Hsu CC, Lin KY, Wang ZH, Lin WL, Yin MC.
Phytomedicine. 2008 Jun 23.

Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice.
Shi Y, Sun J, He H, Guo H, Zhang S.
J Ethnopharmacol. 2008 May 22;117(3):415-9.

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC.
Carcinogenesis. 2008 Jan;29(1):147-56.

Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Wang X, Zhao X, Li D, Lou YQ, Lin ZB, Zhang GL.
Biol Pharm Bull. 2007 Sep;30(9):1702-6.

Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder.
Wanmuang H, Leopairut J, Kositchaiwat C, Wananukul W, Bunyaratvej S.
J Med Assoc Thai. 2007 Jan;90(1):179-81. 

The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.
Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC.
Mol Nutr Food Res. 2007 Dec;51(12):1472-7.

[Mechanism and protective effect of glossy ganoderma decoction on the activities of RNA polymerase in hepatocyte of rabbits with Amanita mushroom poisoning]
Xiao GL, Yang N, Zhang CH, Hu SY.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):637-40.

[Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy]
Wang DH, Weng XC.
Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(19):1618-22.

[The pharmacological study of Ganoderma spores and their active components]
Lin ZB, Wang PY.
Beijing Da Xue Xue Bao. 2006 Oct 18;38(5):541-7.

Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum.
Liu J, Kurashiki K, Shimizu K, Kondo R.
Bioorg Med Chem. 2006 Dec 15;14(24):8654-60.

Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum.
Li YQ, Wang SF.
Biotechnol Lett. 2006 Jun;28(11):837-41.

Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene.
Lakshmi B, Ajith TA, Jose N, Janardhanan KK.
J Ethnopharmacol. 2006 Sep 19;107(2):297-303.

Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells.
Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB.
Life Sci. 2006 Aug 15;79(12):1129-39.

Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine.
Li Y, Yang Y, Fang L, Zhang Z, Jin J, Zhang K.
Am J Chin Med. 2006;34(2):341-9. 

In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.
Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH.
World J Gastroenterol. 2006 Mar 7;12(9):1379-85.

Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats.
Lin WC, Lin WL.
World J Gastroenterol. 2006 Jan 14;12(2):265-70.

5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum.
Liu J, Kurashiki K, Shimizu K, Kondo R.
Biol Pharm Bull. 2006 Feb;29(2):392-5.

Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402.
Yang HL.
Biotechnol Lett. 2005 Jun;27(12):835-8.

Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.
Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LB.
Appl Environ Microbiol. 2005 Jul;71(7):3653-8.

[In vitro inhibitory efects on HBsAg and HBeAg secretion of 3 new components produced by Ganoderma lucidum in the medium contained Radix sophorae flavescentis extract]
Li YQ, Zhang KC.
Wei Sheng Wu Xue Bao. 2005 Aug;45(4):643-6.

Effect of Ganoderma tsugae on chronically carbon tetrachloride-intoxicated rats.
Wu YW, Chen KD, Lin WC.
Am J Chin Med. 2004;32(6):841-50.

Novel antioxidant peptides from fermented mushroom Ganoderma lucidum.
Sun J, He H, Xie BJ.
J Agric Food Chem. 2004 Oct 20;52(21):6646-52.    

Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi).
Yuen MF, Ip P, Ng WK, Lai CL.
J Hepatol. 2004 Oct;41(4):686-7.

Effect of medicinal plant extracts on forced swimming capacity in mice.
Jung K, Kim IH, Han D.
J Ethnopharmacol. 2004 Jul;93(1):75-81.

Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.
Wachtel-Galor S, Tomlinson B, Benzie IF.
Br J Nutr. 2004 Feb;91(2):263-9.

Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P.
Lipids Health Dis. 2004 Feb 18;3:2.

Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components.
Huie CW, Di X.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 5;812(1-2):241-57.

[Clinical observation on treatment of Russula subnigricans poisoning patients by Ganoderma lucidum decoction]
Xiao GL, Liu FY, Chen ZH.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Apr;23(4):278-80.

Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest.
Lin SB, Li CH, Lee SS, Kan LS.
Life Sci. 2003 Apr 11;72(21):2381-90.

Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India.
Lakshmi B, Ajith TA, Sheena N, Gunapalan N, Janardhanan KK.
Teratog Carcinog Mutagen. 2003;Suppl 1:85-97.

Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance.
Kimura Y, Taniguchi M, Baba K.
Anticancer Res. 2002 Nov-Dec;22(6A):3309-18. 

Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
World J Gastroenterol. 2002 Aug;8(4):728-33.

Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum.
Liu X, Yuan JP, Chung CK, Chen XJ.
Cancer Lett. 2002 Aug 28;182(2):155-61. 

Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice.
Shieh YH, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC.
Am J Chin Med. 2001;29(3-4):501-7. 

Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice with an ancient Chinese herb, Ganoderma tsugae.
Lai NS, Lin RH, Lai RS, Kun UC, Leu SC.
Lupus. 2001;10(7):461-5.  

New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Ha TB, Gerhäuser C, Zhang WD, Ho-Chong-Line N, Fourasté I.
Planta Med. 2000 Oct;66(7):681-4.

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).
Kim HS, Kacew S, Lee BM.
Carcinogenesis. 1999 Aug;20(8):1637-40. 

Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum.
Kim DH, Shim SB, Kim NJ, Jang IS.
Biol Pharm Bull. 1999 Feb;22(2):162-4.

Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction.
Park EJ, Ko G, Kim J, Sohn DH.
Biol Pharm Bull. 1997 Apr;20(4):417-20. Erratum in: Biol Pharm Bull 1998 Jun;21(6):649.

Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neo-japonicum.
Lin JM, Lin CC, Chen MF, Ujiie T, Takada A.
J Ethnopharmacol. 1995 Jun 23;47(1):33-41. 

[Testing of plant extracts preparations for prevention and non-toxic therapy of oncologic diseases in experimental models]
Bocharova OA, Serebriakova RV.
Vestn Ross Akad Med Nauk. 1994;(2):52-5.

Evaluation of the anti-inflammatory and liver-protective effects of anoectochilus formosanus, ganoderma lucidum and gynostemma pentaphyllum in rats.
Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG.
Am J Chin Med. 1993;21(1):59-69.

Medicinal benefits of the mushroom Ganoderma.
Jong SC, Birmingham JM.
Adv Appl Microbiol. 1992;37:101-34. Review.

Immunomodulator, LZ-8, prevents antibody production in mice.
Kino K, Sone T, Watanabe J, Yamashita A, Tsuboi H, Miyajima H, Tsunoo H.
Int J Immunopharmacol. 1991;13(8):1109-15.    : 1814848 [PubMed - indexed for MEDLINE]Related citations

Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
Hikino H, Ishiyama M, Suzuki Y, Konno C.
Planta Med. 1989 Oct;55(5):423-8.

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.
Komoda Y, Shimizu M, Sonoda Y, Sato Y.
Chem Pharm Bull (Tokyo). 1989 Feb;37(2):531-3. 

[Therapeutic effect of Ganoderma applonatum (GA) on chronic hepatitis B]
Lin XY, Huang KL, Zhu RP.
Zhonghua Nei Ke Za Zhi. 1988 Oct;27(10):618-20, 652-3.

[Effect of six edible plants on the development of AFB1-induced gamma-glutamyltranspeptidase-positive hepatocyte foci in rats]
Chen ZY, Yan RQ, Qin GZ, Qin LL.
Zhonghua Zhong Liu Za Zhi. 1987 Mar;9(2):109-11.

Some pharmacological actions of the spores of Ganoderma lucidum and the mycelium of Guanoderma capense (Lloyd) Teng cultivated by submerged fermentation.
Gengtao L, Tiantong B, Xinyi N, Shuzhen L, Zhenyu S.
Chin Med J (Engl). 1979 Jul;92(7):496-500.

[A comparison of the protective actions of biphenyl dimethyl-dicarboxylate, trans-stilbene, alcoholic extracts of Fructus schizandrae and Ganoderma against experimental liver injury in mice (author's transl)]
Liu GT, Wang GF, Wei HL, Bao TT, Song ZY.
Yao Xue Xue Bao. 1979;14(10):598-604.

[Some pharmacological actions of Ganoderma lucidum and G. japonicum (FR) Llyod on mouse liver (author's transl)]
Liu GT, Bao TT, Wei HL, Song ZY.
Yao Xue Xue Bao. 1979;14(5):284-7.

Effects of Ganoderma lucidum on obstructive jaundice-induced oxidative stress.
Aydin S, Aytac E, Uzun H, Altug T, Mansur B, Saygili S, Buyukpinarbasili N, Sariyar M.
Asian J Surg. 2010 Oct;33(4):173-80.

[Preparation of Ganoderma lucidum polysaccharides and triterpenes microemulsion and its anticancer effect in mice with transplant Heps tumors].
Chen Y, Lu H, Song S, Jia X.
Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2679-83. Chinese.

Anti-invasive effect of a rare mushroom, Ganoderma colossum , on human hepatoma cells.
Weng CJ, Fang PS, Chen DH, Chen KD, Yen GC.
J Agric Food Chem. 2010 Jul 14;58(13):7657-63.
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