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Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha.
Lai P, Cao X, Xu Q, Liu Y, Li R, Zhang J, Zhang M.
Pharm Biol. 2020 Dec;58(1):760-770. doi: 10.1080/13880209.2020.1798471.

Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice.
Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA.
Nutrients. 2020 Oct 30;12(11):3338. doi: 10.3390/nu12113338.
Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.
Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J.
J Pharm Pharmacol. 2020 Dec;72(12):1946-1955. doi: 10.1111/jphp.13360. Epub 2020 Aug 17.
The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.
Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB.
Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412. Epub 2020 Jul 21.
Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet.
Guo WL , Guo JB , Liu BY , Lu JQ , Chen M , Liu B , Bai WD , Rao PF , Ni L , Lv XC .
Food Funct. 2020 Aug 1;11(8):6818-6833. doi: 10.1039/d0fo00436g. Epub 2020 Jul 20.
Effect of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Capsules on Colistin-Induced Nephrotoxicity.
Talih G, Kantekin ÇÜ, Göçmen Y, Çelik S, Talih T, Esmaoğlu A.
Int J Med Mushrooms. 2020;22(5):445-453. doi: 10.1615/IntJMedMushrooms.2020034229.
Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo.
Sheng F, Zhang L, Wang S, Yang L, Li P.
Nutrients. 2019 Dec 27;12(1):85. doi: 10.3390/nu12010085.
Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.
Li L, Fu WW, Wu RT, Song YH, Wu WY, Yin SH, Li WJ, Xie MY.
Int J Biol Macromol. 2020 Jan 1;142:693-704. doi: 10.1016/j.ijbiomac.2019.10.010. Epub 2019 Nov 15.
Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.
El-Khashab IH.
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1095-1104. doi: 10.31557/APJCP.2021.22.4.1095.
Effects of Ganoderma lucidum and Ceratonia siliqua on blood glucose, lipid profile, and body composition in women with fibromyalgia.
Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MÁ, Gusi N, Collado-Mateo D.
Nutr Hosp. 2021 Feb 23;38(1):139-145. doi: 10.20960/nh.03190.
Protective effect of Ganoderma lucidum spore extract in trimethylamine-N-oxide-induced cardiac dysfunction in rats.
Liu Y, Lai G, Guo Y, Tang X, Shuai O, Xie Y, Wu Q, Chen D, Yuan X.
J Food Sci. 2021 Feb;86(2):546-562. doi: 10.1111/1750-3841.15575. Epub 2021 Jan 12.
Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.
Romero-Córdoba SL, Salido-Guadarrama I, Meneses ME, Cosentino G, Iorio MV, Tagliabue E, Torres N, Sánchez-Tapia M, Bonilla M, Castillo I, Petlacalco B, Tovar AR, Martínez-Carrera D.
Nutrients. 2020 Dec 24;13(1):38. doi: 10.3390/nu13010038.
Pathophysiology of cardiovascular diseases and role of vitamins, herbal extracts in the reduction of cardiovascular risks.
Kumar R, Malik S, Tiwari R, Zhautivova SB, Rakhimovna AH, Raj T, Kumar P.
Cardiovasc Hematol Agents Med Chem. 2020 Dec 16. doi: 10.2174/1871525718666201217102638.
Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/- mice fed with HFD.
Zhang Y, Gu Y, Chen Y, Huang Z, Li M, Jiang W, Chen J, Rao W, Luo S, Chen Y, Chen J, Li L, Jia Y, Liu M, Zhou F.
J Ethnopharmacol. 2021 Feb 10;266:113436. doi: 10.1016/j.jep.2020.113436. Epub 2020 Oct 1.
Inhibitory kinetics and bioactivities of Nuciferine and Methyl Ganoderate on Mucor miehei lipase and 3T3-L1 preadipocytes.
Liu XT, Liu TT, Xu HL, Chen QX, Wang Q.
Int J Biol Macromol. 2020 Nov 15;163:1719-1728. doi: 10.1016/j.ijbiomac.2020.09.127. Epub 2020 Sep 21.
Highly oxygenated lanostane triterpenoids from Ganoderma applanatum as a class of agents for inhibiting lipid accumulation in adipocytes.
Su HG, Wang Q, Zhou L, Peng XR, Xiong WY, Qiu MH.
Bioorg Chem. 2020 Nov;104:104263. doi: 10.1016/j.bioorg.2020.104263. Epub 2020 Sep 3.
Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum.
Yuan S, Pan Y, Zhang Z, He Y, Teng Y, Liang H, Wu X, Yang H, Zhou P.
Biol Pharm Bull. 2020 Oct 1;43(10):1542-1550. doi: 10.1248/bpb.b20-00358. Epub 2020 Aug 5.
 
Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits.
Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW.
Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020.
Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.
Rahman MA, Hossain S, Abdullah N, Aminudin N.
Int J Med Mushrooms. 2020;22(1):93-103. doi: 10.1615/IntJMedMushrooms.2020033383.

Ganoderma polysaccharide and chitosan synergistically ameliorate lipid metabolic disorders and modulate gut microbiota composition in high fat diet-fed golden hamsters.
Tong AJ, Hu RK, Wu LX, Lv XC, Li X, Zhao LN, Liu B.
J Food Biochem. 2020 Jan;44(1):e13109. doi: 10.1111/jfbc.13109. Epub 2019 Dec 3.

Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
Xu Y, Zhang X, Yan XH, Zhang JL, Wang LY, Xue H, Jiang GC, Ma XT, Liu XJ.
Int J Biol Macromol. 2019 Aug 15;135:706-716. doi: 10.1016/j.ijbiomac.2019.05.166. Epub 2019 May 23.

Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T.
J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6). pii: /j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349.

Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System.
Meng J, Yang B.
Adv Exp Med Biol. 2019;1182:181-199. doi: 10.1007/978-981-32-9421-9_7. Review.

Polysaccharide peptide (PsP) Ganoderma lucidum: a potential inducer for vascular repair in type 2 diabetes mellitus model.
Heriansyah T, Nurwidyaningtyas W, Sargowo D, Tjahjono CT, Wihastuti TA.
Vasc Health Risk Manag. 2019 Oct 3;15:419-427. doi: 10.2147/VHRM.S205996. eCollection 2019. Erratum in: Vasc Health Risk Manag. 2019 Nov 05;15:517.

Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment.
Sharma P, Tulsawani R, Agrawal U.
J Food Biochem. 2019 Dec;43(12):e13081. doi: 10.1111/jfbc.13081. Epub 2019 Oct 14.

Preparation of Ganoderma lucidum polysaccharide‑chromium (III) complex and its hypoglycemic and hypolipidemic activities in high-fat and high-fructose diet-induced pre-diabetic mice.
Li L, Xu JX, Cao YJ, Lin YC, Guo WL, Liu JY, Bai WD, Zhang YY, Ni L, Liu B, Rao PF, Lv XC.
Int J Biol Macromol. 2019 Nov 1;140:782-793. doi: 10.1016/j.ijbiomac.2019.08.072. Epub 2019 Aug 8.

Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen's egg test for analysis of micronucleus induction.
Çelik B, Özparlak H.
Biotech Histochem. 2019 Nov;94(8):628-636. doi: 10.1080/10520295.2019.1622784. Epub 2019 Jul 8.

Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation.
Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W.
Int J Mol Sci. 2019 Jun 10;20(11). pii: E2830. doi: 10.3390/ijms20112830.

Characterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum.
Xu Y, Zhang X, Yan XH, Zhang JL, Wang LY, Xue H, Jiang GC, Ma XT, Liu XJ.
Int J Biol Macromol. 2019 Aug 15;135:706-716. doi: 10.1016/j.ijbiomac.2019.05.166. Epub 2019 May 23.

Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats.
Sobowale MT, Ozolua RI, Uwaya DO, Ayinde BA.
Int J Med Mushrooms. 2019;21(2):143-154. doi: 10.1615/IntJMedMushrooms.2019029766.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y.
Drug Deliv. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006.

Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis.
Zhao C, Fan J, Liu Y, Guo W, Cao H, Xiao J, Wang Y, Liu B.
Food Chem. 2019 Jan 15;271:148-156. doi: 10.1016/j.foodchem.2018.07.115. Epub 2018 Jul 18.

Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Liang Z, Yuan Z, Li G, Fu F, Shan Y.
J Med Food. 2018 Dec;21(12):1218-1227. doi: 10.1089/jmf.2018.4182. Epub 2018 Sep 5.

Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide.
Wu S.
Int J Biol Macromol. 2018 Oct 15;118(Pt B):2001-2005. doi: 10.1016/j.ijbiomac.2018.07.082. Epub 2018 Jul 22.

Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver.
Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim HJ.
J Clin Med. 2018 Jun 15;7(6). pii: E152. doi: 10.3390/jcm7060152.

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats.
Guo WL, Pan YY, Li L, Li TT, Liu B, Lv XC.
Food Funct. 2018 Jun 20;9(6):3419-3431. doi: 10.1039/c8fo00836a.

Evaluation of the Antioxidative and Hypo-cholesterolemic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Ameliorating Cardiovascular Disease.
Rahman MA, Abdullah N, Aminudin N.
Int J Med Mushrooms. 2018;20(10):961-969. doi: 10.1615/IntJMedMushrooms.2018028370.

Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice.
Oluba OM.
Lipids Health Dis. 2019 Jan 12;18(1):12. doi: 10.1186/s12944-018-0951-x.

Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.
Zhong D, Xie Z, Huang B, Zhu S, Wang G, Zhou H, Lin S, Lin Z, Yang B.
Cell Physiol Biochem. 2018;49(3):1163-1179. doi: 10.1159/000493297. Epub 2018 Sep 7.

OS 10-03 THE DISTINCTIVE EFFECT OF POLYSACCHARIDE PEPTIDES GANODERMA LUCIDUM AS ANTI ATHEROGENESIS IN STABLE ANGINA PATIENTS.
Ubaidillah N, Sargowo D, Widya A, Jakfar V, Proboretno KS, Failasufi M, Warahugraha Y, Ramadhan F, Wulandari H, Putri DH.
J Hypertens. 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e72.

Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors.
Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A.
Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. doi: 10.1002/14651858.CD007259.pub2.

Development of liposomal Ganoderma lucidum polysaccharide: formulation optimization and evaluation of its immunological activity.
Liu Z, Ma X, Deng B, Huang Y, Bo R, Gao Z, Yu Y, Hu Y, Liu J, Wu Y, Wang D.
Carbohydr Polym. 2015 Mar 6;117:510-7. doi: 10.1016/j.carbpol.2014.09.093. Epub 2014 Oct 15.

Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties.
Osińska-Jaroszuk M, Jaszek M, Mizerska-Dudka M, Błachowicz A, Rejczak TP, Janusz G, Wydrych J, Polak J, Jarosz-Wilkołazka A, Kandefer-Szerszeń M.
Biomed Res Int. 2014;2014:743812. doi: 10.1155/2014/743812. Epub 2014 Jul 10.

Evaluation of a crataegus-based multiherb formula for dyslipidemia: a randomized, double-blind, placebo-controlled clinical trial.
Hu M, Zeng W, Tomlinson B.
Evid Based Complement Alternat Med. 2014;2014:365742. doi: 10.1155/2014/365742. Epub 2014 Apr 16.

HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression.
Yang Q, Wang S, Xie Y, Sun J, Wang J.
Int J Biol Macromol. 2010 Mar 1;46(2):167-72.

Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW.
Phytomedicine. 2009 May;16(5):426-36.

Prevention of cisplatin induced nephrotoxicity by terpenes isolated from Ganoderma lucidum occurring in Southern Parts of India.
Pillai TG, John M, Sara Thomas G.
Exp Toxicol Pathol. 2009 Dec 2.

Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo-polymers in streptozotocin-induced diabetic rats.
Yang BK, Jung YS, Song CH.
Phytother Res. 2007 Nov;21(11):1066-9. 

Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Wang X, Zhao X, Li D, Lou YQ, Lin ZB, Zhang GL.
Biol Pharm Bull. 2007 Sep;30(9):1702-6.

Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus.
Campos Ziegenbein F, Hanssen HP, König WA.
Phytochemistry. 2006 Jan;67(2):202-11.

Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice.
He CY, Li WD, Guo SX, Lin SQ, Lin ZB.
J Asian Nat Prod Res. 2006 Dec;8(8):705-11.

Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model.
Lin JY, Chen ML, Lin BF.
Food Chem Toxicol. 2006 Dec;44(12):2025-32.

Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene.
Lakshmi B, Ajith TA, Jose N, Janardhanan KK.
J Ethnopharmacol. 2006 Sep 19;107(2):297-303.

Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.
Hajjaj H, Macé C, Roberts M, Niederberger P, Fay LB.
Appl Environ Microbiol. 2005 Jul;71(7):3653-8. 

[Effects of ganoderma lucidum polysaccharides on serum lipids and lipoperoxidation in experimental hyperlipidemic rats]
Chen WQ, Luo SH, Ll HZ, Yang H.
Zhongguo Zhong Yao Za Zhi. 2005 Sep;30(17):1358-60.

Cellular and physiological effects of Ganoderma lucidum (Reishi).
Sliva D.
Mini Rev Med Chem. 2004 Oct;4(8):873-9.

Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.
Berger A, Rein D, Kratky E, Monnard I, Hajjaj H, Meirim I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P.
Lipids Health Dis. 2004 Feb 18;3:2.

In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage.
Zhang HN, He JH, Yuan L, Lin ZB.
Life Sci. 2003 Sep 19;73(18):2307-19.

[Antioxidant effect of Ganoderma polysaccharide peptide]
You YH, Lin ZB.
Yao Xue Xue Bao. 2003 Feb;38(2):85-8.

Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.
Shiao MS.
Chem Rec. 2003;3(3):172-80.

[Advances of pharmacological effects of triterpenes from Ganoderma lucidum]
Luo J, Lin ZB.
Yao Xue Xue Bao. 2002 Jul;37(7):574-8.

[Effect of lugu Ganoderma lucidum on low-density lipoprotein oxidation and monocyte adhesion to endothelium]
Zhang HM, Yao WJ, Tian HK.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jul;22(7):534-7.

Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies.
Hikino H, Ishiyama M, Suzuki Y, Konno C.
Planta Med. 1989 Oct;55(5):423-8. 

Ganoderic acid and its derivatives as cholesterol synthesis inhibitors.
Komoda Y, Shimizu M, Sonoda Y, Sato Y.
Chem Pharm Bull (Tokyo). 1989 Feb;37(2):531-3.

[Anti-atherosclerotic properties of higher mushrooms (a clinico-experimental investigation)]
Li Khva Ren, Vasil'ev AV, Orekhov AN, Tertov VV, Tutel'ian VA.
Vopr Pitan. 1989 Jan-Feb;(1):16-9.

Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum.
Kim SD.
J Microbiol Biotechnol. 2010 Nov;20(11):1521-3.
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