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癌・免疫 血糖 血圧 肝臓 脂質代謝
         
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Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor.
Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, Yang BX.
Acta Pharmacol Sin. 2021 Apr 29. doi: 10.1038/s41401-021-00669-6. Online ahead of print.

Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFbeta-1 and TLR-4/NFkappaB signalling pathways.
Hassan HM, Mahran YF, Ghanim AMH.
J Pharm Pharmacol. 2021 Apr 13:rgab058. doi: 10.1093/jpp/rgab058. Online ahead of print.

Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl(4)-induced hepatotoxicity.
Song X, Cui W, Gao Z, Zhang J, Jia L.
Int Immunopharmacol. 2021 Mar 31;96:107554. doi: 10.1016/j.intimp.2021.107554. Online ahead of print.

PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.
Tsai IL, Tsai CY, Kuo LL, Woung LC, Ku RY, Cheng YH.
Exp Eye Res. 2021 May;206:108539. doi: 10.1016/j.exer.2021.108539. Epub 2021 Mar 17.

Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system.
Li H, Xiao Y, Han L, Jia Y, Luo S, Zhang D, Zhang L, Wu P, Xiao C, Kan W, Du J, Bao H.
Brain Res Bull. 2021 Jun;171:16-24. doi: 10.1016/j.brainresbull.2021.03.002. Epub 2021 Mar 8.

Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model.
Kahveci R, Kahveci FO, Gokce EC, Gokce A, Kısa Ü, Sargon MF, Fesli R, Gürer B.
World Neurosurg. 2021 Mar 6:S1878-8750(21)00322-3. doi: 10.1016/j.wneu.2021.02.129. Online ahead of print.

Prevention of dextran sulfate sodium-induced mouse colitis by the fungal protein Ling Zhi-8 via promoting the barrier function of intestinal epithelial cells.
Chen YH, Shin JY, Wei HM, Lin CC, Yu LCH, Liao WT, Chen DC, Chu CL.
Food Funct. 2021 Mar 1;12(4):1639-1650. doi: 10.1039/d0fo02604b.

Anti-inflammatory effects of Ganoderma lucidum sterols via attenuation of the p38 MAPK and NF-kappaB pathways in LPS-induced RAW 264.7 macrophages.
Xu J, Xiao C, Xu H, Yang S, Chen Z, Wang H, Zheng B, Mao B, Wu X.
Food Chem Toxicol. 2021 Apr;150:112073. doi: 10.1016/j.fct.2021.112073. Epub 2021 Feb 22.

Genome sequencing and annotation and phylogenomic analysis of the medicinal mushroom Amauroderma rugosum, a traditional medicinal species in the family Ganodermataceae.
Lin W, Shi Y, Jia G, Sun H, Sun T, Hou D.
Mycologia. 2021 Mar-Apr;113(2):268-277. doi: 10.1080/00275514.2020.1851135. Epub 2021 Feb 8.

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation.
Sang T, Guo C, Guo D, Wu J, Wang Y, Wang Y, Chen J, Chen C, Wu K, Na K, Li K, Fang L, Guo C, Wang X.
Carbohydr Polym. 2021 Mar 15;256:117594. doi: 10.1016/j.carbpol.2020.117594. Epub 2021 Jan 4.

The protective effects of the Ganoderma atrum polysaccharide against acrylamide-induced inflammation and oxidative damage in rats.
Jiang G, Lei A, Chen Y, Yu Q, Xie J, Yang Y, Yuan T, Su D.
Food Funct. 2021 Jan 7;12(1):397-407. doi: 10.1039/d0fo01873b. Epub 2020 Dec 18.

Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study.
Shaher F, Wang S, Qiu H, Hu Y, Zhang Y, Wang W, Al-Ward H, Abdulghani MAM, Baldi S, Zhou S.
Diabetes Metab Syndr Obes. 2020 Dec 7;13:4809-4822. doi: 10.2147/DMSO.S281527. eCollection 2020.

Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities.
Han J, Liu W, Li M, Gu Y, Zhang Y, Yuan T.
Molecules. 2020 Oct 19;25(20):4807. doi: 10.3390/molecules25204807.

Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway.
Yarmohammadi F, Rezaee R, Karimi G.
Phytother Res. 2021 Mar;35(3):1163-1175. doi: 10.1002/ptr.6882. Epub 2020 Sep 28.

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.
Oluwafemi Adetuyi B, Olamide Okeowo T, Adefunke Adetuyi O, Abraham Adebisi O, Ogunlana OO, Janet Oretade O, Marraiki N, Beshbishy AM, N Welson N, Batiha GE.
Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313.

New advances and potentials of fungal immunomodulatory proteins for therapeutic purposes.
Ejike UC, Chan CJ, Okechukwu PN, Lim RLH.
Crit Rev Biotechnol. 2020 Dec;40(8):1172-1190. doi: 10.1080/07388551.2020.1808581. Epub 2020 Aug 28.

Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.
Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J.
J Pharm Pharmacol. 2020 Dec;72(12):1946-1955. doi: 10.1111/jphp.13360. Epub 2020 Aug 17.

Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology.
Ryu DH, Cho JY, Sadiq NB, Kim JC, Lee B, Hamayun M, Lee TS, Kim HS, Park SH, Nho CW, Kim HY.
Food Chem. 2021 Jan 15;335:127645. doi: 10.1016/j.foodchem.2020.127645. Epub 2020 Jul 25.

The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation.
Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB.
Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412. Epub 2020 Jul 21.

A recombinant protein rLZ-8, originally extracted from Ganoderma lucidum, ameliorates OVA-induced lung inflammation by regulating Th17/Treg balance.
Liu H, Qiu F, Wang Y, Liang F, Liang J, Lin C, Liang J, Gong B, Chan S, De Zhang Z, Lai X, Hou S, Dai Z.
J Leukoc Biol. 2020 Aug;108(2):531-545. doi: 10.1002/JLB.5MA0420-453R. Epub 2020 Jun 24.

Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS.
Hilliard A, Mendonca P, Soliman KFA.
J Neuroimmunol. 2020 Aug 15;345:577269. doi: 10.1016/j.jneuroim.2020.577269. Epub 2020 May 26.

Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model.
Roda E, Luca F, Iorio CD, Ratto D, Siciliani S, Ferrari B, Cobelli F, Borsci G, Priori EC, Chinosi S, Ronchi A, Franco R, Di Francia R, Berretta M, Locatelli CA, Gregori A, Savino E, Bottone MG, Rossi P.
Int J Mol Sci. 2020 May 14;21(10):3479. doi: 10.3390/ijms21103479.

Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model.
Hu X, Yu Q, Hou K, Ding X, Chen Y, Xie J, Nie S, Xie M.
Food Chem Toxicol. 2020 Jun;140:111321. doi: 10.1016/j.fct.2020.111321. Epub 2020 Apr 11.

Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety.
Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH, Pintus G.
Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422. eCollection 2020.

Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits.
Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW.
Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020.

A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2.
Wang H, Peng X, Ge Y, Zhang S, Wang Z, Fan Y, Huang W, Qiu M, Ye RD.
Front Pharmacol. 2020 Mar 24;11:337. doi: 10.3389/fphar.2020.00337. eCollection 2020.

Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.
Li HN, Zhao LL, Zhou DY, Chen DQ.
Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.

Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases.
Geng X, Zhong D, Su L, Lin Z, Yang B.
Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20.

Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.
Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T.
J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6). pii: /j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349.

Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo.
Sheng F, Zhang L, Wang S, Yang L, Li P.
Nutrients. 2019 Dec 27;12(1). pii: E85. doi: 10.3390/nu12010085.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care.
Yin Z, Yang B, Ren H.
Adv Exp Med Biol. 2019;1182:311-321. doi: 10.1007/978-981-32-9421-9_14. Review.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications.
Geng X, Zhong D, Su L, Yang B.
Adv Exp Med Biol. 2019;1182:243-262. doi: 10.1007/978-981-32-9421-9_10. Review.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury.
Qiu Z, Zhong D, Yang B.
Adv Exp Med Biol. 2019;1182:217-242. doi: 10.1007/978-981-32-9421-9_9. Review.

Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury.
Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X.
Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24.

Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.
Li L, Fu WW, Wu RT, Song YH, Wu WY, Yin SH, Li WJ, Xie MY.
Int J Biol Macromol. 2020 Jan 1;142:693-704. doi: 10.1016/j.ijbiomac.2019.10.010. Epub 2019 Nov 15.

Herbal Medicine for Slowing Aging and Aging-Associated Conditions: Efficacy, Mechanisms, and Safety.
Phu HT, Thuan DTB, Nguyen THD, Posadino AM, Eid AH, Pintus G.
Curr Vasc Pharmacol. 2019 Jul 15. doi: 10.2174/1570161117666190715121939. [Epub ahead of print]

Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling.
You YK, Luo Q, Wu WF, Zhang JJ, Zhu HJ, Lao L, Lan HY, Chen HY, Cheng YX.
J Cell Mol Med. 2019 Aug;23(8):5576-5587. doi: 10.1111/jcmm.14454. Epub 2019 Jun 18.

Anti-inflammatory, anti-nociceptive and sedative-hypnotic activities of lucidone D extracted from Ganoderma lucidum.
Feng X, Wang Y.
Cell Mol Biol (Noisy-le-grand). 2019 Apr 30;65(4):37-42.

Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects.
Wu YL, Han F, Luan SS, Ai R, Zhang P, Li H, Chen LX.
J Agric Food Chem. 2019 May 8;67(18):5147-5158. doi: 10.1021/acs.jafc.9b01195. Epub 2019 Apr 24.

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.
Lu SY, Peng XR, Dong JR, Yan H, Kong QH, Shi QQ, Li DS, Zhou L, Li ZR, Qiu MH.
Fitoterapia. 2019 Apr;134:58-64. doi: 10.1016/j.fitote.2019.01.013. Epub 2019 Feb 11.

Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.
Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.
Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559. eCollection 2019.

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.
Lu SY, Peng XR, Dong JR, Yan H, Kong QH, Shi QQ, Li DS, Zhou L, Li ZR, Qiu MH.
Fitoterapia. 2019 Feb 11;134:58-64. doi: 10.1016/j.fitote.2019.01.013.

Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.
Li T, Yu H, Song Y, Zhang R, Ge M.
J Trace Elem Med Biol. 2019 Mar;52:118-125. doi: 10.1016/j.jtemb.2018.12.010. Epub 2018 Dec 15.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N.
Int J Med Mushrooms. 2018;20(9):809-823. doi: 10.1615/IntJMedMushrooms.2018027359.

GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells.
Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL.
Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.
J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. eCollection 2018.

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.
Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. eCollection 2018 May 15. Review.

Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation.
Hsu PL, Lin YC, Ni H, Mo FE.
Oxid Med Cell Longev. 2018 Apr 11;2018:3491703. doi: 10.1155/2018/3491703. eCollection 2018.

Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora.
Liu JQ, Lian CL, Hu TY, Wang CF, Xu Y, Xiao L, Liu ZQ, Qiu SQ, Cheng BH.
Food Chem. 2018 Oct 15;263:155-162. doi: 10.1016/j.foodchem.2018.04.097. Epub 2018 Apr 25.

Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice.
Fan S, Huang X, Wang S, Li C, Zhang Z, Xie M, Nie S.
Food Chem Toxicol. 2018 Sep;119:66-72. doi: 10.1016/j.fct.2018.05.027. Epub 2018 May 16.

In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.
Abu-Serie MM, Habashy NH, Attia WE.
BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.

Protective properties of combined fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction.
Fan ST, Nie SP, Huang XJ, Wang S, Hu JL, Xie JH, Nie QX, Xie MY.
Int J Biol Macromol. 2018 Jul 15;114:1049-1055. doi: 10.1016/j.ijbiomac.2018.04.004. Epub 2018 Apr 4.

Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.
Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, Gui S, Wang D, Yin X, Wang F.
Exp Ther Med. 2018 Jan;15(1):847-853. doi: 10.3892/etm.2017.5472. Epub 2017 Nov 8.

Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts.
Lee PH, Hsieh PL, Liao YW, Yu CC.
Environ Toxicol. 2018 Jan;33(1):32-40. doi: 10.1002/tox.22489. Epub 2017 Oct 6.

Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages.
Nagai K, Ueno Y, Tanaka S, Hayashi R, Shinagawa K, Chayama K.
Cell Immunol. 2017 Oct;320:20-28. doi: 10.1016/j.cellimm.2017.08.001. Epub 2017 Aug 4.

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.
Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C.
Nutrients. 2017 Feb 28;9(3). pii: E210. doi: 10.3390/nu9030210.

The improvement of M1 polarization in macrophages by glycopeptide derived from Ganoderma lucidum.
Sun LX, Lin ZB, Lu J, Li WD, Niu YD, Sun Y, Hu CY, Zhang GQ, Duan XS.
Immunol Res. 2017 Jun;65(3):658-665. doi: 10.1007/s12026-017-8893-3.

Ganoderma lucidum for Cancer Treatment: We Are Close but Still Not There.
Cheng S, Sliva D.
Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review.

A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.
Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.
Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.

Anti-inflammatory activity of mycelial extracts from medicinal mushrooms.
Geng Y, Zhu S, Lu Z, Xu H, Shi JS, Xu ZH.
Int J Med Mushrooms. 2014;16(4):319-25.

Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.
Choi S, Nguyen VT, Tae N, Lee S, Ryoo S, Min BS, Lee JH.
Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42. doi: 10.1016/j.taap.2014.09.007. Epub 2014 Sep 16.

Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.
Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ.
Springerplus. 2014 Jun 12;3:297. doi: 10.1186/2193-1801-3-297. eCollection 2014.

Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.
Zhou Y, Chen S, Ding R, Yao W, Gao X.
Mediators Inflamm. 2014;2014:691285. doi: 10.1155/2014/691285. Epub 2014 May 22.

Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum.
Bhardwaj N, Katyal P, Sharma AK.
Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17.

Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 β Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice.
Liang CJ, Lee CW, Sung HC, Chen YH, Chiang YC, Hsu HY, Tseng YC, Li CY, Wang SH, Chen YL.
Evid Based Complement Alternat Med. 2014;2014:305149. doi: 10.1155/2014/305149. Epub 2014 Mar 4.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.
Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.
PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040. eCollection 2014.

Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides.
Wang J, Zhang Y, Yuan Y, Yue T.
Food Chem Toxicol. 2014 Jun;68:183-9. doi: 10.1016/j.fct.2014.03.003. Epub 2014 Mar 10.

Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., beta-glucan induces Toll-like receptors and fails to induce inflammatory cytokines in NF-kappaB inhibitor-treated macrophages.
Batbayar S, Kim MJ, Kim HW.
Int J Med Mushrooms. 2011;13(3):213-25.

The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.
Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K, Chayama K.
Scand J Immunol. 2011 Nov;74(5):454-62. doi: 10.1111/j.1365-3083.2011.02601.x.

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum..
Joseph S, Sabulal B, George V, Antony KR, Janardhanan KK.
Acta Pharm. 2011 Sep 1;61(3):335-42.

Ganoderma applanatum terpenes protect mouse liver against benzo(α)pyren-induced oxidative stress and inflammation.
Ma JQ, Liu CM, Qin ZH, Jiang JH, Sun YZ.
Environ Toxicol Pharmacol. 2011 May;31(3):460-8. Epub 2011 Feb 26..

Ganoderma lucidum Polysaccharides Attenuate Endotoxin-Induced Intercellular Cell Adhesion Molecule-1 Expression in Cultured Smooth Muscle Cells and in the Neointima in Mice.
Lin CY, Chen YH, Lin CY, Hsu HY, Wang SH, Liang CJ, Kuan II, Wu PJ, Pai PY, Wu CC, Chen YL.
J Agric Food Chem. 2010 Aug 5.

The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells.
Cheng CH, Leung AY, Chen CF.
Nutr Cancer. 2010 Jul;62(5):648-58

Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum.
Dudhgaonkar S, Thyagarajan A, Sliva D.
Int Immunopharmacol. 2009 Oct;9(11):1272-80.

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration Through Inhibition of Microglial Activation.
Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P.
Evid Based Complement Alternat Med. 2009 Jul 16.

Application of proteomics in Chinese medicine research.
Cho WC.
Am J Chin Med. 2007;35(6):911-22.

Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial.
Li EK, Tam LS, Wong CK, Li WC, Lam CW, Wachtel-Galor S, Benzie IF, Bao YX, Leung PC, Tomlinson B.
Arthritis Rheum. 2007 Oct 15;57(7):1143-50.

Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.
Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y.
Chem Biodivers. 2007 Feb;4(2):224-31.

Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo.
Chen ML, Lin BF.
Int Arch Allergy Immunol. 2007;143(1):21-30.

Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model.
Lin JY, Chen ML, Lin BF.
Food Chem Toxicol. 2006 Dec;44(12):2025-32.

Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells.
Lai KN, Chan LY, Tang SC, Leung JC.
Nephrol Dial Transplant. 2006 May;21(5):1188-97. Epub 2006 Jan 24.PMID: 16434408 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human.
Blum K, Meshkin B, Downs BW.
Med Hypotheses. 2006;66(5):1008-18.

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model.
Lin JY, Chen ML, Chiang BL, Lin BF.
Int Immunopharmacol. 2006 Feb;6(2):241-51.

Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells.
Hong KJ, Dunn DM, Shen CL, Pence BC.
Phytother Res. 2004 Sep;18(9):768-70.PMID: 15478180 [PubMed - indexed for MEDLINE]Related citations

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