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癌・免疫 血糖 血圧 肝臓 脂質代謝
         
鎮痛 老化・美容 アレルギー 炎症  
         

Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.
Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.
Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559. eCollection 2019.

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.
Lu SY, Peng XR, Dong JR, Yan H, Kong QH, Shi QQ, Li DS, Zhou L, Li ZR, Qiu MH.
Fitoterapia. 2019 Feb 11;134:58-64. doi: 10.1016/j.fitote.2019.01.013.

Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.
Li T, Yu H, Song Y, Zhang R, Ge M.
J Trace Elem Med Biol. 2019 Mar;52:118-125. doi: 10.1016/j.jtemb.2018.12.010. Epub 2018 Dec 15.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N.
Int J Med Mushrooms. 2018;20(9):809-823. doi: 10.1615/IntJMedMushrooms.2018027359.

GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells.
Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL.
Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.
J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. eCollection 2018.

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.
Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. eCollection 2018 May 15. Review.

Ganoderma Triterpenoids Exert Antiatherogenic Effects in Mice by Alleviating Disturbed Flow-Induced Oxidative Stress and Inflammation.
Hsu PL, Lin YC, Ni H, Mo FE.
Oxid Med Cell Longev. 2018 Apr 11;2018:3491703. doi: 10.1155/2018/3491703. eCollection 2018.

Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora.
Liu JQ, Lian CL, Hu TY, Wang CF, Xu Y, Xiao L, Liu ZQ, Qiu SQ, Cheng BH.
Food Chem. 2018 Oct 15;263:155-162. doi: 10.1016/j.foodchem.2018.04.097. Epub 2018 Apr 25.

Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice.
Fan S, Huang X, Wang S, Li C, Zhang Z, Xie M, Nie S.
Food Chem Toxicol. 2018 Sep;119:66-72. doi: 10.1016/j.fct.2018.05.027. Epub 2018 May 16.

In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.
Abu-Serie MM, Habashy NH, Attia WE.
BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.

Protective properties of combined fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction.
Fan ST, Nie SP, Huang XJ, Wang S, Hu JL, Xie JH, Nie QX, Xie MY.
Int J Biol Macromol. 2018 Jul 15;114:1049-1055. doi: 10.1016/j.ijbiomac.2018.04.004. Epub 2018 Apr 4.

Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.
Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, Gui S, Wang D, Yin X, Wang F.
Exp Ther Med. 2018 Jan;15(1):847-853. doi: 10.3892/etm.2017.5472. Epub 2017 Nov 8.

Inhibitory effect of GMI, an immunomodulatory protein from Ganoderma microsporum, on myofibroblast activity and proinflammatory cytokines in human fibrotic buccal mucosal fibroblasts.
Lee PH, Hsieh PL, Liao YW, Yu CC.
Environ Toxicol. 2018 Jan;33(1):32-40. doi: 10.1002/tox.22489. Epub 2017 Oct 6.

Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages.
Nagai K, Ueno Y, Tanaka S, Hayashi R, Shinagawa K, Chayama K.
Cell Immunol. 2017 Oct;320:20-28. doi: 10.1016/j.cellimm.2017.08.001. Epub 2017 Aug 4.

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.
Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C.
Nutrients. 2017 Feb 28;9(3). pii: E210. doi: 10.3390/nu9030210.

The improvement of M1 polarization in macrophages by glycopeptide derived from Ganoderma lucidum.
Sun LX, Lin ZB, Lu J, Li WD, Niu YD, Sun Y, Hu CY, Zhang GQ, Duan XS.
Immunol Res. 2017 Jun;65(3):658-665. doi: 10.1007/s12026-017-8893-3.

Ganoderma lucidum for Cancer Treatment: We Are Close but Still Not There.
Cheng S, Sliva D.
Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review.

A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.
Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.
Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.

Anti-inflammatory activity of mycelial extracts from medicinal mushrooms.
Geng Y, Zhu S, Lu Z, Xu H, Shi JS, Xu ZH.
Int J Med Mushrooms. 2014;16(4):319-25.

Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.
Choi S, Nguyen VT, Tae N, Lee S, Ryoo S, Min BS, Lee JH.
Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42. doi: 10.1016/j.taap.2014.09.007. Epub 2014 Sep 16.

Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.
Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ.
Springerplus. 2014 Jun 12;3:297. doi: 10.1186/2193-1801-3-297. eCollection 2014.

Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.
Zhou Y, Chen S, Ding R, Yao W, Gao X.
Mediators Inflamm. 2014;2014:691285. doi: 10.1155/2014/691285. Epub 2014 May 22.

Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum.
Bhardwaj N, Katyal P, Sharma AK.
Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17.

Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1 β Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice.
Liang CJ, Lee CW, Sung HC, Chen YH, Chiang YC, Hsu HY, Tseng YC, Li CY, Wang SH, Chen YL.
Evid Based Complement Alternat Med. 2014;2014:305149. doi: 10.1155/2014/305149. Epub 2014 Mar 4.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.
Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.
PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040. eCollection 2014.

Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides.
Wang J, Zhang Y, Yuan Y, Yue T.
Food Chem Toxicol. 2014 Jun;68:183-9. doi: 10.1016/j.fct.2014.03.003. Epub 2014 Mar 10.

Medicinal mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., beta-glucan induces Toll-like receptors and fails to induce inflammatory cytokines in NF-kappaB inhibitor-treated macrophages.
Batbayar S, Kim MJ, Kim HW.
Int J Med Mushrooms. 2011;13(3):213-25.

The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.
Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K, Chayama K.
Scand J Immunol. 2011 Nov;74(5):454-62. doi: 10.1111/j.1365-3083.2011.02601.x.

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum..
Joseph S, Sabulal B, George V, Antony KR, Janardhanan KK.
Acta Pharm. 2011 Sep 1;61(3):335-42.

Ganoderma applanatum terpenes protect mouse liver against benzo(α)pyren-induced oxidative stress and inflammation.
Ma JQ, Liu CM, Qin ZH, Jiang JH, Sun YZ.
Environ Toxicol Pharmacol. 2011 May;31(3):460-8. Epub 2011 Feb 26..

Ganoderma lucidum Polysaccharides Attenuate Endotoxin-Induced Intercellular Cell Adhesion Molecule-1 Expression in Cultured Smooth Muscle Cells and in the Neointima in Mice.
Lin CY, Chen YH, Lin CY, Hsu HY, Wang SH, Liang CJ, Kuan II, Wu PJ, Pai PY, Wu CC, Chen YL.
J Agric Food Chem. 2010 Aug 5.

The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells.
Cheng CH, Leung AY, Chen CF.
Nutr Cancer. 2010 Jul;62(5):648-58

Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum.
Dudhgaonkar S, Thyagarajan A, Sliva D.
Int Immunopharmacol. 2009 Oct;9(11):1272-80.

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration Through Inhibition of Microglial Activation.
Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P.
Evid Based Complement Alternat Med. 2009 Jul 16.

Application of proteomics in Chinese medicine research.
Cho WC.
Am J Chin Med. 2007;35(6):911-22.

Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial.
Li EK, Tam LS, Wong CK, Li WC, Lam CW, Wachtel-Galor S, Benzie IF, Bao YX, Leung PC, Tomlinson B.
Arthritis Rheum. 2007 Oct 15;57(7):1143-50.

Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.
Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y.
Chem Biodivers. 2007 Feb;4(2):224-31.

Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo.
Chen ML, Lin BF.
Int Arch Allergy Immunol. 2007;143(1):21-30.

Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model.
Lin JY, Chen ML, Lin BF.
Food Chem Toxicol. 2006 Dec;44(12):2025-32.

Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells.
Lai KN, Chan LY, Tang SC, Leung JC.
Nephrol Dial Transplant. 2006 May;21(5):1188-97. Epub 2006 Jan 24.PMID: 16434408 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human.
Blum K, Meshkin B, Downs BW.
Med Hypotheses. 2006;66(5):1008-18.

Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model.
Lin JY, Chen ML, Chiang BL, Lin BF.
Int Immunopharmacol. 2006 Feb;6(2):241-51.

Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells.
Hong KJ, Dunn DM, Shen CL, Pence BC.
Phytother Res. 2004 Sep;18(9):768-70.PMID: 15478180 [PubMed - indexed for MEDLINE]Related citations

Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.
Wachtel-Galor S, Tomlinson B, Benzie IF.
Br J Nutr. 2004 Feb;91(2):263-9.

Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator.
Liu YH, Tsai CF, Kao MC, Lai YL, Tsai JJ.
J Microbiol Immunol Infect. 2003 Dec;36(4):236-42.

Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India.
Lakshmi B, Ajith TA, Sheena N, Gunapalan N, Janardhanan KK.
Teratog Carcinog Mutagen. 2003;Suppl 1:85-97.

Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
World J Gastroenterol. 2002 Aug;8(4):728-33.

Cytotoxicity and immunogenicity of SACCHACHITIN and its mechanism of action on skin wound healing.
Hung WS, Fang CL, Su CH, Lai WF, Chang YC, Tsai YH.
J Biomed Mater Res. 2001 Jul;56(1):93-100.

On the anti-inflammatory and anti-phospholipase A(2) activity of extracts from lanostane-rich species.
Giner-Larza EM, Máñez S, Giner-Pons RM, Carmen Recio M, Ríos JL.
J Ethnopharmacol. 2000 Nov;73(1-2):61-9.

Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea.
Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY.
Biochem J. 1997 Apr 15;323 ( Pt 2):557-65.

[Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia.]
Ding H, Zhou M, Zhang RP, Xu SL.
Sheng Li Xue Bao. 2010 Dec 25;62(6):547-554. Chinese.

GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells.
Lin CH, Hsiao YM, Ou CC, Lin YW, Chiu YL, Lue KH, Chang JG, Ko JL.
J Agric Food Chem. 2010 Nov 24;58(22):12014-21. Epub 2010 Oct 28.
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