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Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

Hu Y, Wang SX, Wu FY, Wu KJ, Shi RP, Qin LH, Lu CF, Wang SQ, Wang FF, Zhou S.

Biomed Res Int. 2022 Mar 8;2022:4314415. doi: 10.1155/2022/4314415. eCollection 2022.

Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum.

Zhang Y, Pan Y, Li J, Zhang Z, He Y, Yang H, Zhou P.

Molecules. 2022 Feb 22;27(5):1457. doi: 10.3390/molecules27051457.

Triterpenoids and meroterpenoids from the edible Ganoderma resinaceum and their potential anti-inflammatory, antioxidant and anti-apoptosis activities.

Kou RW, Xia B, Wang ZJ, Li JN, Yang JR, Gao YQ, Yin X, Gao JM.

Bioorg Chem. 2022 Apr;121:105689. doi: 10.1016/j.bioorg.2022.105689. Epub 2022 Feb 21.

Sexual Crossing, Chromosome-Level Genome Sequences, and Comparative Genomic Analyses for the Medicinal Mushroom Taiwanofungus Camphoratus (Syn. Antrodia Cinnamomea, Antrodia Camphorata).

Chen CL, Li WC, Chuang YC, Liu HC, Huang CH, Lo KY, Chen CY, Chang FM, Chang GA, Lin YL, Yang WD, Su CH, Yeh TM, Wang TF.

Microbiol Spectr. 2022 Feb 23;10(1):e0203221. doi: 10.1128/spectrum.02032-21. Epub 2022 Feb 23.

Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells.

Zhang Y, Song S, Li H, Wang X, Song L, Xue J.

Food Funct. 2022 Feb 21;13(4):1941-1952. doi: 10.1039/d1fo03698j.

Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats.

Özden H, Şahin Y, Kilitçi A, Karaca G, Gömeç M, Yildiz A, Uçar C.

Ann Surg Treat Res. 2022 Jan;102(1):29-35. doi: 10.4174/astr.2022.102.1.29. Epub 2022 Jan 3.

Ganoderma modulates allergic asthma pathologic features via anti-inflammatory effects.

Li Y, Li M, Wang R, Wang B, Athari SS, Wang J.

Respir Physiol Neurobiol. 2022 May;299:103843. doi: 10.1016/j.resp.2022.103843. Epub 2022 Jan 10.

Ganoderma applanatum polysaccharides and ethanol extracts promote the recovery of colitis through intestinal barrier protection and gut microbiota modulations.

Li M, Yu L, Zhai Q, Liu B, Zhao J, Zhang H, Chen W, Tian F.

Food Funct. 2022 Jan 24;13(2):688-701. doi: 10.1039/d1fo03677g.

A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice.

Shao W, Xiao C, Yong T, Zhang Y, Hu H, Xie T, Liu R, Huang L, Li X, Xie Y, Zhang J, Chen S, Cai M, Chen D, Liu Y, Gao X, Wu Q.

Int J Biol Macromol. 2022 Feb 1;197:23-38. doi: 10.1016/j.ijbiomac.2021.12.034. Epub 2021 Dec 15.

Novelkaraya gum micro-particles loaded Ganoderma lucidum polysaccharide regulate sex hormones, oxidative stress and inflammatory cytokine levels in cadmium induced testicular toxicity in experimental animals.

Bin-Jumah MN, Nadeem MS, Gilani SJ, Imam SS, Alshehri S, Kazmi I.

Int J Biol Macromol. 2022 Jan 1;194:338-346. doi: 10.1016/j.ijbiomac.2021.11.072. Epub 2021 Nov 18.

Ganoderic Acid A Attenuates IL-1β-Induced Inflammation in Human Nucleus Pulposus Cells Through Inhibiting the NF-κB Pathway.

Zheng S, Ma J, Zhao X, Yu X, Ma Y.

Inflammation. 2022 Apr;45(2):851-862. doi: 10.1007/s10753-021-01590-0. Epub 2021 Nov 5.

Effects of natural extracts in the treatment of oral ulcers: A systematic review of evidence from experimental studies in animals.

Wen SD, Sans-Serramitjana E, Santander JF, Sánchez MR, Salazar-Aguilar P, Zepeda AB, Alvarado SI, Miranda IB.

J Clin Exp Dent. 2021 Oct 1;13(10):e1038-e1048. doi: 10.4317/jced.58567. eCollection 2021 Oct.

Ganoderterpene A, a New Triterpenoid from Ganoderma lucidum, Attenuates LPS-Induced Inflammation and Apoptosis via Suppressing MAPK and TLR-4/NF-κB Pathways in BV-2 Cells.

Kou RW, Gao YQ, Xia B, Wang JY, Liu XN, Tang JJ, Yin X, Gao JM.

J Agric Food Chem. 2021 Nov 3;69(43):12730-12740. doi: 10.1021/acs.jafc.1c04905. Epub 2021 Oct 20.

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis.

Shao G, He J, Meng J, Ma A, Geng X, Zhang S, Qiu Z, Lin D, Li M, Zhou H, Lin S, Yang B.

Int J Mol Sci. 2021 Sep 23;22(19):10229. doi: 10.3390/ijms221910229.

A blend of 3 mushrooms dose-dependently increases butyrate production by the gut microbiota.

Verhoeven J, Keller D, Verbruggen S, Abboud KY, Venema K.

Benef Microbes. 2021 Nov 16;12(6):601-612. doi: 10.3920/BM2021.0015. Epub 2021 Sep 30.

Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1.

Xu ZH, Su X, Yang G, Qin T, Liu Y.

J Pharm Pharmacol. 2022 Jan 5;74(1):124-130. doi: 10.1093/jpp/rgab142.

FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma.

Peng XR, Wang Q, Wang HR, Hu K, Xiong WY, Qiu MH.

Bioorg Chem. 2021 Nov;116:105338. doi: 10.1016/j.bioorg.2021.105338. Epub 2021 Sep 8.

Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression.

Zhang L, Zhang L, Sui R.

Neuropsychiatr Dis Treat. 2021 Aug 14;17:2671-2681. doi: 10.2147/NDT.S317207. eCollection 2021.

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties.

Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A.

Phytother Res. 2021 Nov;35(11):6030-6062. doi: 10.1002/ptr.7215. Epub 2021 Aug 19.

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum.

Sadiq NB, Ryu DH, Cho JY, Lee AH, Song DG, Dorjsembe B, Kim JC, Jung JH, Nho CW, Hamayun M, Yang SH, Kim HY.

Molecules. 2021 Jul 25;26(15):4484. doi: 10.3390/molecules26154484.

Rationalization of Mushroom-Based Preventive and Therapeutic Approaches to COVID-19: Review.

Rahman MA, Rahman MS, Bashir NMB, Mia R, Hossain A, Saha SK, Kakon AJ, Sarker NC.

Int J Med Mushrooms. 2021;23(5):1-11. doi: 10.1615/IntJMedMushrooms.2021038285.

Polysaccharide from Ganoderma lucidum ameliorates cognitive impairment by regulating the inflammation of the brain-liver axis in rats.

Zhang Y , Li H , Song L , Xue J , Wang X , Song S , Wang S .

Food Funct. 2021 Aug 2;12(15):6900-6914. doi: 10.1039/d1fo00355k.

Metagenomic characterization of indoor dust fungal associated with allergy and lung inflammation among school children.

Isa KNM, Jalaludin J, Elias SM, Than LTL, Jabbar MA, Saudi ASM, Norbäck D, Hashim JH, Hashim Z.

Ecotoxicol Environ Saf. 2021 Sep 15;221:112430. doi: 10.1016/j.ecoenv.2021.112430. Epub 2021 Jun 17.

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon.

Guo C, Guo D, Fang L, Sang T, Wu J, Guo C, Wang Y, Wang Y, Chen C, Chen J, Chen R, Wang X.

Carbohydr Polym. 2021 Sep 1;267:118231. doi: 10.1016/j.carbpol.2021.118231. Epub 2021 May 20.

Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway.

Ma JQ, Zhang YJ, Tian ZK.

Chem Biol Interact. 2021 Aug 1;344:109529. doi: 10.1016/j.cbi.2021.109529. Epub 2021 May 23.

Ganoderma lucidum triterpenoids and polysaccharides attenuate atherosclerotic plaque in high-fat diet rabbits.

Li Y, Tang J, Gao H, Xu Y, Han Y, Shang H, Lu Y, Qin C.

Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1929-1938. doi: 10.1016/j.numecd.2021.03.023. Epub 2021 Apr 6.

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor.

Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, Yang BX.

Acta Pharmacol Sin. 2021 Oct;42(10):1703-1713. doi: 10.1038/s41401-021-00669-6. Epub 2021 Apr 29.

Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFβ-1 and TLR-4/NFκB signalling pathways.

Hassan HM, Mahran YF, Ghanim AMH.

J Pharm Pharmacol. 2021 Aug 12;73(9):1250-1261. doi: 10.1093/jpp/rgab058.

Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor.

Jia Y, Zhang D, Yin H, Li H, Du J, Bao H.

Neurochem Res. 2021 Jul;46(7):1725-1736. doi: 10.1007/s11064-021-03303-3. Epub 2021 Apr 5.

Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl4-induced hepatotoxicity.

Song X, Cui W, Gao Z, Zhang J, Jia L.

Int Immunopharmacol. 2021 Jul;96:107554. doi: 10.1016/j.intimp.2021.107554. Epub 2021 Mar 31.

Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model.

Kahveci R, Kahveci FO, Gokce EC, Gokce A, Kısa Ü, Sargon MF, Fesli R, Gürer B.

World Neurosurg. 2021 Jun;150:e287-e297. doi: 10.1016/j.wneu.2021.02.129. Epub 2021 Mar 6.

Characterization and Hepatoprotections of Ganoderma lucidum Polysaccharides against Multiple Organ Dysfunction Syndrome in Mice.

Zhang Y, Feng Y, Wang W, Jia L, Zhang J.

Oxid Med Cell Longev. 2021 Feb 3;2021:9703682. doi: 10.1155/2021/9703682. eCollection 2021.

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor. Abulizi A, Hu L, Ma A, Shao FY, Zhu HZ, Lin SM, Shao GY, Xu Y, Ran JH, Li J, Zhou H, Lin DM, Wang LF, Li M, Yang BX. Acta Pharmacol Sin. 2021 Apr 29. doi: 10.1038/s41401-021-00669-6. Online ahead of print. Ganoderma lucidum ameliorates the diabetic nephropathy via down-regulatory effect on TGFbeta-1 and TLR-4/NFkappaB signalling pathways. Hassan HM, Mahran YF, Ghanim AMH. J Pharm Pharmacol. 2021 Apr 13:rgab058. doi: 10.1093/jpp/rgab058. Online ahead of print. Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl(4)-induced hepatotoxicity. Song X, Cui W, Gao Z, Zhang J, Jia L. Int Immunopharmacol. 2021 Mar 31;96:107554. doi: 10.1016/j.intimp.2021.107554. Online ahead of print. PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage. Tsai IL, Tsai CY, Kuo LL, Woung LC, Ku RY, Cheng YH. Exp Eye Res. 2021 May;206:108539. doi: 10.1016/j.exer.2021.108539. Epub 2021 Mar 17. Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. Li H, Xiao Y, Han L, Jia Y, Luo S, Zhang D, Zhang L, Wu P, Xiao C, Kan W, Du J, Bao H. Brain Res Bull. 2021 Jun;171:16-24. doi: 10.1016/j.brainresbull.2021.03.002. Epub 2021 Mar 8. Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model. Kahveci R, Kahveci FO, Gokce EC, Gokce A, Kısa Ü, Sargon MF, Fesli R, Gürer B. World Neurosurg. 2021 Mar 6:S1878-8750(21)00322-3. doi: 10.1016/j.wneu.2021.02.129. Online ahead of print. Prevention of dextran sulfate sodium-induced mouse colitis by the fungal protein Ling Zhi-8 via promoting the barrier function of intestinal epithelial cells. Chen YH, Shin JY, Wei HM, Lin CC, Yu LCH, Liao WT, Chen DC, Chu CL. Food Funct. 2021 Mar 1;12(4):1639-1650. doi: 10.1039/d0fo02604b. Anti-inflammatory effects of Ganoderma lucidum sterols via attenuation of the p38 MAPK and NF-kappaB pathways in LPS-induced RAW 264.7 macrophages. Xu J, Xiao C, Xu H, Yang S, Chen Z, Wang H, Zheng B, Mao B, Wu X. Food Chem Toxicol. 2021 Apr;150:112073. doi: 10.1016/j.fct.2021.112073. Epub 2021 Feb 22. Genome sequencing and annotation and phylogenomic analysis of the medicinal mushroom Amauroderma rugosum, a traditional medicinal species in the family Ganodermataceae. Lin W, Shi Y, Jia G, Sun H, Sun T, Hou D. Mycologia. 2021 Mar-Apr;113(2):268-277. doi: 10.1080/00275514.2020.1851135. Epub 2021 Feb 8. Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation. Sang T, Guo C, Guo D, Wu J, Wang Y, Wang Y, Chen J, Chen C, Wu K, Na K, Li K, Fang L, Guo C, Wang X. Carbohydr Polym. 2021 Mar 15;256:117594. doi: 10.1016/j.carbpol.2020.117594. Epub 2021 Jan 4. The protective effects of the Ganoderma atrum polysaccharide against acrylamide-induced inflammation and oxidative damage in rats. Jiang G, Lei A, Chen Y, Yu Q, Xie J, Yang Y, Yuan T, Su D. Food Funct. 2021 Jan 7;12(1):397-407. doi: 10.1039/d0fo01873b. Epub 2020 Dec 18. Effect and Mechanism of Ganoderma lucidum Spores on Alleviation of Diabetic Cardiomyopathy in a Pilot in vivo Study. Shaher F, Wang S, Qiu H, Hu Y, Zhang Y, Wang W, Al-Ward H, Abdulghani MAM, Baldi S, Zhou S. Diabetes Metab Syndr Obes. 2020 Dec 7;13:4809-4822. doi: 10.2147/DMSO.S281527. eCollection 2020. Lanostane Triterpenoids from the Fruiting Bodies of Fomes officinalis and Their Anti-Inflammatory Activities. Han J, Liu W, Li M, Gu Y, Zhang Y, Yuan T. Molecules. 2020 Oct 19;25(20):4807. doi: 10.3390/molecules25204807. Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway. Yarmohammadi F, Rezaee R, Karimi G. Phytother Res. 2021 Mar;35(3):1163-1175. doi: 10.1002/ptr.6882. Epub 2020 Sep 28. Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model. Oluwafemi Adetuyi B, Olamide Okeowo T, Adefunke Adetuyi O, Abraham Adebisi O, Ogunlana OO, Janet Oretade O, Marraiki N, Beshbishy AM, N Welson N, Batiha GE. Biology (Basel). 2020 Sep 27;9(10):313. doi: 10.3390/biology9100313. New advances and potentials of fungal immunomodulatory proteins for therapeutic purposes. Ejike UC, Chan CJ, Okechukwu PN, Lim RLH. Crit Rev Biotechnol. 2020 Dec;40(8):1172-1190. doi: 10.1080/07388551.2020.1808581. Epub 2020 Aug 28. Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats. Xiao H, Fang Z, He X, Ding P, Cao Y, Chan S, Hou S, Liang J. J Pharm Pharmacol. 2020 Dec;72(12):1946-1955. doi: 10.1111/jphp.13360. Epub 2020 Aug 17. Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology. Ryu DH, Cho JY, Sadiq NB, Kim JC, Lee B, Hamayun M, Lee TS, Kim HS, Park SH, Nho CW, Kim HY. Food Chem. 2021 Jan 15;335:127645. doi: 10.1016/j.foodchem.2020.127645. Epub 2020 Jul 25. The effect of Ganoderma lucidum spore oil in early skin wound healing: interactions of skin microbiota and inflammation. Jiao C, Xie Y, Yun H, Liang H, He C, Jiang A, Wu Q, Yang BB. Aging (Albany NY). 2020 Jul 21;12(14):14125-14140. doi: 10.18632/aging.103412. Epub 2020 Jul 21. A recombinant protein rLZ-8, originally extracted from Ganoderma lucidum, ameliorates OVA-induced lung inflammation by regulating Th17/Treg balance. Liu H, Qiu F, Wang Y, Liang F, Liang J, Lin C, Liang J, Gong B, Chan S, De Zhang Z, Lai X, Hou S, Dai Z. J Leukoc Biol. 2020 Aug;108(2):531-545. doi: 10.1002/JLB.5MA0420-453R. Epub 2020 Jun 24. Involvement of NFkB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS. Hilliard A, Mendonca P, Soliman KFA. J Neuroimmunol. 2020 Aug 15;345:577269. doi: 10.1016/j.jneuroim.2020.577269. Epub 2020 May 26. Novel Medicinal Mushroom Blend as a Promising Supplement in Integrative Oncology: A Multi-Tiered Study using 4T1 Triple-Negative Mouse Breast Cancer Model. Roda E, Luca F, Iorio CD, Ratto D, Siciliani S, Ferrari B, Cobelli F, Borsci G, Priori EC, Chinosi S, Ronchi A, Franco R, Di Francia R, Berretta M, Locatelli CA, Gregori A, Savino E, Bottone MG, Rossi P. Int J Mol Sci. 2020 May 14;21(10):3479. doi: 10.3390/ijms21103479. Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model. Hu X, Yu Q, Hou K, Ding X, Chen Y, Xie J, Nie S, Xie M. Food Chem Toxicol. 2020 Jun;140:111321. doi: 10.1016/j.fct.2020.111321. Epub 2020 Apr 11. Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety. Shaito A, Thuan DTB, Phu HT, Nguyen THD, Hasan H, Halabi S, Abdelhady S, Nasrallah GK, Eid AH, Pintus G. Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422. eCollection 2020. Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits. Lee MF, Chiang CH, Lin SJ, Song PP, Liu HC, Wu TJ, Lin WW. Biomed Res Int. 2020 Jan 27;2020:3495682. doi: 10.1155/2020/3495682. eCollection 2020. A Ganoderma-Derived Compound Exerts Inhibitory Effect Through Formyl Peptide Receptor 2.

Wang H, Peng X, Ge Y, Zhang S, Wang Z, Fan Y, Huang W, Qiu M, Ye RD.

Front Pharmacol. 2020 Mar 24;11:337. doi: 10.3389/fphar.2020.00337. eCollection 2020.

Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway.

Li HN, Zhao LL, Zhou DY, Chen DQ.

Med Sci Monit. 2020 Apr 4;26:e921905. doi: 10.12659/MSM.921905.

Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases.

Geng X, Zhong D, Su L, Lin Z, Yang B.

Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20.

Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2.

Wihastuti TA, Amiruddin R, Cesa FY, Alkaf AI, Setiawan M, Heriansyah T.

J Basic Clin Physiol Pharmacol. 2020 Feb 7;30(6). pii: /j/jbcpp.2019.30.issue-6/jbcpp-2019-0349/jbcpp-2019-0349.xml. doi: 10.1515/jbcpp-2019-0349.

Deacetyl Ganoderic Acid F Inhibits LPS-Induced Neural Inflammation via NF-κB Pathway Both In Vitro and In Vivo.

Sheng F, Zhang L, Wang S, Yang L, Li P.

Nutrients. 2019 Dec 27;12(1). pii: E85. doi: 10.3390/nu12010085.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care.

Yin Z, Yang B, Ren H.

Adv Exp Med Biol. 2019;1182:311-321. doi: 10.1007/978-981-32-9421-9_14. Review.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications.

Geng X, Zhong D, Su L, Yang B.

Adv Exp Med Biol. 2019;1182:243-262. doi: 10.1007/978-981-32-9421-9_10. Review.

Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Liver Injury.

Qiu Z, Zhong D, Yang B.

Adv Exp Med Biol. 2019;1182:217-242. doi: 10.1007/978-981-32-9421-9_9. Review.

Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury.

Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, Hattori M, Zhang H, Liang Y, Yu S, Wang X.

Cytokine. 2020 Mar;127:154917. doi: 10.1016/j.cyto.2019.154917. Epub 2019 Nov 24.

Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.

Li L, Fu WW, Wu RT, Song YH, Wu WY, Yin SH, Li WJ, Xie MY.

Int J Biol Macromol. 2020 Jan 1;142:693-704. doi: 10.1016/j.ijbiomac.2019.10.010. Epub 2019 Nov 15.

Herbal Medicine for Slowing Aging and Aging-Associated Conditions: Efficacy, Mechanisms, and Safety.

Phu HT, Thuan DTB, Nguyen THD, Posadino AM, Eid AH, Pintus G.

Curr Vasc Pharmacol. 2019 Jul 15. doi: 10.2174/1570161117666190715121939. [Epub ahead of print]

Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling.

You YK, Luo Q, Wu WF, Zhang JJ, Zhu HJ, Lao L, Lan HY, Chen HY, Cheng YX.

J Cell Mol Med. 2019 Aug;23(8):5576-5587. doi: 10.1111/jcmm.14454. Epub 2019 Jun 18.

Anti-inflammatory, anti-nociceptive and sedative-hypnotic activities of lucidone D extracted from Ganoderma lucidum.

Feng X, Wang Y.

Cell Mol Biol (Noisy-le-grand). 2019 Apr 30;65(4):37-42.

Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects.

Wu YL, Han F, Luan SS, Ai R, Zhang P, Li H, Chen LX.

J Agric Food Chem. 2019 May 8;67(18):5147-5158. doi: 10.1021/acs.jafc.9b01195. Epub 2019 Apr 24.

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.

Lu SY, Peng XR, Dong JR, Yan H, Kong QH, Shi QQ, Li DS, Zhou L, Li ZR, Qiu MH.

Fitoterapia. 2019 Apr;134:58-64. doi: 10.1016/j.fitote.2019.01.013. Epub 2019 Feb 11.

Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.

Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.

Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559. eCollection 2019.

Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities.

Lu SY, Peng XR, Dong JR, Yan H, Kong QH, Shi QQ, Li DS, Zhou L, Li ZR, Qiu MH.

Fitoterapia. 2019 Feb 11;134:58-64. doi: 10.1016/j.fitote.2019.01.013.

Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.

Li T, Yu H, Song Y, Zhang R, Ge M.

J Trace Elem Med Biol. 2019 Mar;52:118-125. doi: 10.1016/j.jtemb.2018.12.010. Epub 2018 Dec 15.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.

Chen YS, Chen QZ, Wang ZJ, Hua C.

Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).

Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N.

Int J Med Mushrooms. 2018;20(9):809-823. doi: 10.1615/IntJMedMushrooms.2018027359.

GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells.

Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL.

Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.

Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.

Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.

J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. eCollection 2018.

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.

Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.

Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. eCollection 2018 May 15. Review.

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Food Chem Toxicol. 2018 Sep;119:66-72. doi: 10.1016/j.fct.2018.05.027. Epub 2018 May 16.

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BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.

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Int J Biol Macromol. 2018 Jul 15;114:1049-1055. doi: 10.1016/j.ijbiomac.2018.04.004. Epub 2018 Apr 4.

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Exp Ther Med. 2018 Jan;15(1):847-853. doi: 10.3892/etm.2017.5472. Epub 2017 Nov 8.

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Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages.

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The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.
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Ganoderma lucidum Polysaccharides Attenuate Endotoxin-Induced Intercellular Cell Adhesion Molecule-1 Expression in Cultured Smooth Muscle Cells and in the Neointima in Mice.
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Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model.
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Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells.
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Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator.
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Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India.
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Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
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World J Gastroenterol. 2002 Aug;8(4):728-33.

Cytotoxicity and immunogenicity of SACCHACHITIN and its mechanism of action on skin wound healing.
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J Biomed Mater Res. 2001 Jul;56(1):93-100.

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[Ganoderma lucidum extract protects dopaminergic neurons through inhibiting the production of inflammatory mediators by activated microglia.]
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GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells.
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