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The Protective Role of GMI, an Immunomodulatory Protein From Ganoderma microsporum, on 5-Fluorouracil-Induced Oral and Intestinal Mucositis.
Li CH, Ko JL, Ou CC, Lin WL, Yen CC, Hsu CT, Hsiao YP.
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419833795. doi: 10.1177/1534735419833795.

Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro.
Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F.
Front Pharmacol. 2019 Feb 19;10:115. doi: 10.3389/fphar.2019.00115. eCollection 2019.

Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecal microbiota and gene expression of colonic epithelial cells.
Xie J, Liu Y, Chen B, Zhang G, Ou S, Luo J, Peng X.
Food Nutr Res. 2019 Feb 12;63. doi: 10.29219/fnr.v63.1559. eCollection 2019.

Antiproliferative Effects of a Triterpene-Enriched Extract from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), on Human Lung Cancer Cells.
Zolj S, Smith MP, Goines JC, Ali TS, Huff MO, Robinson DL, Lau JM.
Int J Med Mushrooms. 2018;20(12):1173-1183. doi: 10.1615/IntJMedMushrooms.2018028823.

Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?
Lans C.
J Ethnopharmacol. 2019 Feb 15;236:366-392. doi: 10.1016/j.jep.2019.02.030.

Antioxidant and Anti-Inflammatory Activity and Cytotoxicity of Ethanol Extracts from Rhynchosia nulubilis Cultivated with Ganoderma lucidum Mycelium.
Park MH, Kim M.
Prev Nutr Food Sci. 2018 Dec;23(4):326-334. doi: 10.3746/pnf.2018.23.4.326. Epub 2018 Dec 31.

Medicinal Mushrooms (PDQ®): Patient Version.
PDQ Integrative, Alternative, and Complementary Therapies Editorial Board.
PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-.2019 Jan 17.

Anti-breast Cancer Enhancement of a Polysaccharide From Spore of Ganoderma lucidum With Paclitaxel: Suppression on Tumor Metabolism With Gut Microbiota Reshaping.
Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X.
Front Microbiol. 2018 Dec 17;9:3099. doi: 10.3389/fmicb.2018.03099. eCollection 2018.

Article Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice.
Hu F, Yan Y, Wang CW, Liu Y, Wang JJ, Zhou F, Zeng QH, Zhou X, Chen J, Wang AJ, Zhou JD.
Chin J Integr Med. 2019 Mar;25(3):203-209. doi: 10.1007/s11655-018-3060-9. Epub 2018 Dec 15.

Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway.
Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM.
Oncotarget. 2018 Nov 13;9(89):35907-35921. doi: 10.18632/oncotarget.26294. eCollection 2018 Nov 13.

(±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear.
Qin FY, Yan YM, Tu ZC, Cheng YX.
Nat Prod Res. 2018 Dec 5:1-7. doi: 10.1080/14786419.2018.1531859.

Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum.
Saltarelli R, Palma F, Gioacchini AM, Calcabrini C, Mancini U, De Bellis R, Stocchi V, Potenza L.
J Ethnopharmacol. 2019 Mar 1;231:464-473. doi: 10.1016/j.jep.2018.11.041. Epub 2018 Dec 1.

Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma.
Gill BS, Navgeet, Kumar S.
Mol Cell Biochem. 2018 Dec 3. doi: 10.1007/s11010-018-3485-7.

Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan.
Sharif S, Atta A, Huma T, Shah AA, Afzal G, Rashid S, Shahid M, Mustafa G.
Food Sci Nutr. 2018 Sep 14;6(8):2170-2176. doi: 10.1002/fsn3.781. eCollection 2018 Nov.

Ganoderma immunomodulatory protein and chidamide down-regulate integrin-related signaling pathway result in migration inhibition and apoptosis induction.
Lu CT, Leong PY, Hou TY, Huang SJ, Hsiao YP, Ko JL.
Phytomedicine. 2018 Dec 1;51:39-47. doi: 10.1016/j.phymed.2018.06.023. Epub 2018 Jun 23.

Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells.
Hseu YC, Shen YC, Kao MC, Mathew DC, Karuppaiya P, Li ML, Yang HL.
Food Chem Toxicol. 2019 Feb;124:30-44. doi: 10.1016/j.fct.2018.11.043. Epub 2018 Nov 19.
 
Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response.
Zhang S, Pang G, Chen C, Qin J, Yu H, Liu Y, Zhang X, Song Z, Zhao J, Wang F, Wang Y, Zhang LW.
Carbohydr Polym. 2019 Feb 1;205:192-202. doi: 10.1016/j.carbpol.2018.10.028. Epub 2018 Oct 13.

Ganoderma: A Cancer Immunotherapy Review.
Cao Y, Xu X, Liu S, Huang L, Gu J.
Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217. eCollection 2018. Review.

Ganoderic acid A exerts antitumor activity against MDA-MB-231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway.
Yang Y, Zhou H, Liu W, Wu J, Yue X, Wang J, Quan L, Liu H, Guo L, Wang Z, Lian X, Zhang Q.
Oncol Lett. 2018 Nov;16(5):6515-6521. doi: 10.3892/ol.2018.9475. Epub 2018 Sep 21.

Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.
Guo J, Yuan C, Huang M, Liu Y, Chen Y, Liu C, Chen Y.
Drug Deliv. 2018 Nov;25(1):1802-1810. doi: 10.1080/10717544.2018.1516006.

Herb-Drug Interactions in Cancer Care.
Yeung KS, Gubili J, Mao JJ.
Oncology (Williston Park). 2018 Oct 15;32(10):516-20. Review.

Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N.
Int J Med Mushrooms. 2018;20(9):809-823. doi: 10.1615/IntJMedMushrooms.2018027359.

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats.
Veena RK, Ajith TA, Janardhanan KK.
Int J Med Mushrooms. 2018;20(8):761-774. doi: 10.1615/IntJMedMushrooms.2018027010.

Ganoderma tsugae Inhibits the SREBP-1/AR Axis Leading to Suppression of Cell Growth and Activation of Apoptosis in Prostate Cancer Cells.
Huang SY, Huang GJ, Wu HC, Kao MC, Huang WC.
Molecules. 2018 Oct 5;23(10). pii: E2539. doi: 10.3390/molecules23102539.

Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells.
Wu K, Na K, Chen D, Wang Y, Pan H, Wang X.
Int J Oncol. 2018 Dec;53(6):2356-2368. doi: 10.3892/ijo.2018.4578. Epub 2018 Sep 28.

Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines.
Su HG, Zhou QM, Guo L, Huang YJ, Peng C, Xiong L.
Phytochemistry. 2018 Dec;156:89-95. doi: 10.1016/j.phytochem.2018.09.003. Epub 2018 Sep 18.

From nutraceutical to clinical trial: frontiers in Ganoderma development.
Hsu KD, Cheng KC.
Appl Microbiol Biotechnol. 2018 Nov;102(21):9037-9051. doi: 10.1007/s00253-018-9326-5. Epub 2018 Sep 4. Review.

Antitumor Activity of Extract From the Sporoderm-Breaking Spore of Ganoderma lucidum: Restoration on Exhausted Cytotoxic T Cell With Gut Microbiota Remodeling.
Su J, Su L, Li D, Shuai O, Zhang Y, Liang H, Jiao C, Xu Z, Lai Y, Xie Y.
Front Immunol. 2018 Jul 31;9:1765. doi: 10.3389/fimmu.2018.01765. eCollection 2018.

Cytotoxic and N-Acetyltransferase Inhibitory Meroterpenoids from Ganoderma cochlear.
Cheng LZ, Qin FY, Ma XC, Wang SM, Yan YM, Cheng YX.
Molecules. 2018 Jul 20;23(7). pii: E1797. doi: 10.3390/molecules23071797.

(±) Cochlearoids N-P: three pairs of phenolic meroterpenoids from the fungus Ganoderma cochlear and their bioactivities.
Qin FY, Yan YM, Tu ZC, Cheng YX.
J Asian Nat Prod Res. 2018 Jul 9:1-9. doi: 10.1080/10286020.2018.1481052

GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells.
Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL.
Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.

Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities.
Qin FY, Yan YM, Tu ZC, Cheng YX.
Fitoterapia. 2018 Sep;129:167-172. doi: 10.1016/j.fitote.2018.06.019. Epub 2018 Jun 30.

Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms.
Rubel R, Santa HSD, Dos Santos LF, Fernandes LC, Figueiredo BC, Soccol CR.
Int J Med Mushrooms. 2018;20(4):393-403. doi: 10.1615/IntJMedMushrooms.2018025979.

The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death.
Liu G, Wang K, Kuang S, Cao R, Bao L, Liu R, Liu H, Sun C.
Cell Death Dis. 2018 Jun 7;9(6):689. doi: 10.1038/s41419-018-0731-6.

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.
Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. eCollection 2018 May 15. Review.

Apoptosis induced by 9,11‑dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent.
Zheng L, Wong YS, Shao M, Huang S, Wang F, Chen J.
Mol Med Rep. 2018 Jul;18(1):938-944. doi: 10.3892/mmr.2018.9035. Epub 2018 May 17.
 
Tumor inhibitory effects of intravesical Ganoderma lucidum instillation in the syngeneic orthotopic MB49/C57 bladder cancer mice model.
Yuen JWM, Mak DSY, Chan ES, Gohel MDI, Ng CF.
J Ethnopharmacol. 2018 Sep 15;223:113-121. doi: 10.1016/j.jep.2018.05.020. Epub 2018 May 18.

Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms.
Saad HM, Sim KS, Tan YS.
Int J Med Mushrooms. 2018;20(2):141-153. doi: 10.1615/IntJMedMushrooms.2018025463.

Steroids from Ganoderma sinense as new natural inhibitors of cancer-associated mutant IDH1.
Zheng M, Tang R, Deng Y, Yang K, Chen L, Li H.
Bioorg Chem. 2018 Sep;79:89-97. doi: 10.1016/j.bioorg.2018.04.016. Epub 2018 Apr 30.

Molecular cloning, codon-optimized gene expression, and bioactivity assessment of two novel fungal immunomodulatory proteins from Ganoderma applanatum in Pichia.
Zhou S, Guan S, Duan Z, Han X, Zhang X, Fan W, Li H, Chen L, Ma H, Liu H, Ruan Y, Lin J.
Appl Microbiol Biotechnol. 2018 Jul;102(13):5483-5494. doi: 10.1007/s00253-018-9022-5. Epub 2018 Apr 28.

Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China.
Zeng P, Guo Z, Zeng X, Hao C, Zhang Y, Zhang M, Liu Y, Li H, Li J, Zhang L.
J Cell Mol Med. 2018 Jul;22(7):3278-3297. doi: 10.1111/jcmm.13613. Epub 2018 Apr 24. Review.

Comprehensive comparison of polysaccharides from Ganoderma lucidum and G. sinense: chemical, antitumor, immunomodulating and gut-microbiota modulatory properties.
Li LF, Liu HB, Zhang QW, Li ZP, Wong TL, Fung HY, Zhang JX, Bai SP, Lu AP, Han QB.
Sci Rep. 2018 Apr 18;8(1):6172. doi: 10.1038/s41598-018-22885-7.

Ganoderma lucidum Polysaccharide Peptide Attenuates Skin Flap Ischemia-Reperfusion Injury in a Thioredoxin-Dependent Manner.
Ren H, Meng X, Yin J, Sun J, Huang Q, Yin Z.
Plast Reconstr Surg. 2018 Jul;142(1):23e-33e. doi: 10.1097/PRS.0000000000004503.

Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.
Wang C, Shi S, Chen Q, Lin S, Wang R, Wang S, Chen C.
Integr Cancer Ther. 2018 Sep;17(3):674-683. doi: 10.1177/1534735418762537. Epub 2018 Apr 2.

Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies.
Elkhateeb WA, Zaghlol GM, El-Garawani IM, Ahmed EF, Rateb ME, Abdel Moneim AE.
Biomed Pharmacother. 2018 May;101:264-277. doi: 10.1016/j.biopha.2018.02.058. Epub 2018 Feb 27.

A multi-center survey on dietary knowledge and behavior among inpatients in oncology department.
Cong M, Wang J, Fang Y, Liu Y, Sun M, Wu Q, Wang K, Huang Y, Ling Y, Liu Y, Li Q, Liu Y, Zhu J, Zhu L, Zheng Z, Li L, Liu D, Liu Z, Shi H, Yuan P.
Support Care Cancer. 2018 Jul;26(7):2285-2292. doi: 10.1007/s00520-018-4057-9. Epub 2018 Feb 5.

Protective effects of Ganoderma triterpenoids on cadmium-induced oxidative stress and inflammatory injury in chicken livers.
Li T, Yu H, Song Y, Zhang R, Ge M.
J Trace Elem Med Biol. 2019 Mar;52:118-125. doi: 10.1016/j.jtemb.2018.12.010. Epub 2018 Dec 15.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Chen YS, Chen QZ, Wang ZJ, Hua C.
Pharmacology. 2019;103(3-4):143-150. doi: 10.1159/000493896. Epub 2019 Jan 23.

Involvement of N-glycan in Multiple Receptor Tyrosine Kinases Targeted by Ling-Zhi-8 for Suppressing HCC413 Tumor Progression.
You RI, Wu WS, Cheng CC, Wu JR, Pan SM, Chen CW, Hu CT.
Cancers (Basel). 2018 Dec 21;11(1). pii: E9. doi: 10.3390/cancers11010009.

Anti-inflammatory and Neuroprotective Effects of Fungal Immunomodulatory Protein Involving Microglial Inhibition.
Chen WY, Chang CY, Li JR, Wang JD, Wu CC, Kuan YH, Liao SL, Wang WY, Chen CJ.
Int J Mol Sci. 2018 Nov 21;19(11). pii: E3678. doi: 10.3390/ijms19113678.

Ganoderic Acid A Protects Rat H9c2 Cardiomyocytes from Hypoxia-Induced Injury via Up-Regulating miR-182-5p.
Zhang X, Xiao C, Liu H.
Cell Physiol Biochem. 2018;50(6):2086-2096. doi: 10.1159/000495053. Epub 2018 Nov 9.

Pharmacological effects of natural Ganoderma and its extracts on neurological diseases: A comprehensive review.
Zhao C, Zhang C, Xing Z, Ahmad Z, Li JS, Chang MW.
Int J Biol Macromol. 2019 Jan;121:1160-1178. doi: 10.1016/j.ijbiomac.2018.10.076. Epub 2018 Oct 18. Review.

The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network.
Zhao R, Chen Q, He YM.
Sci Rep. 2018 Aug 23;8(1):12680. doi: 10.1038/s41598-018-30881-0.

Role of Hydroalcoholic Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Facilitating Cellular Acclimatization in a Low-Oxygen Microenvironment.
Koganti P, Tulsawani R, Sharma P, Sharma M, Arora S, Misra K.
Int J Med Mushrooms. 2018;20(5):431-444. doi: 10.1615/IntJMedMushrooms.2018026075.

Protein components of water extracts from fruiting bodies of the reishi mushroom Ganoderma lucidum contribute to the production of functional molecules.
Liu G, Wang K, Kuang S, Cao R, Bao L, Liu R, Liu H, Sun C.
Cell Death Dis. 2018 Jun 7;9(6):689. doi: 10.1038/s41419-018-0731-6.

Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora.
Liu JQ, Lian CL, Hu TY, Wang CF, Xu Y, Xiao L, Liu ZQ, Qiu SQ, Cheng BH.
Food Chem. 2018 Oct 15;263:155-162. doi: 10.1016/j.foodchem.2018.04.097. Epub 2018 Apr 25.

Purification and identification of an actinomycin D analogue from actinomycetes associated with Ganoderma applanatum via magnetic molecularly imprinted polymers and tandem mass spectrometry.
Li CG, Yuan B, Dong MM, Zhou PY, Hao YX, Sun YY, Xu MK, Li D, Kai GY, Jiang JH.
Food Chem Toxicol. 2018 Sep;119:150-160. doi: 10.1016/j.fct.2018.05.015. Epub 2018 May 17.

In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris.
Abu-Serie MM, Habashy NH, Attia WE.
BMC Complement Altern Med. 2018 May 10;18(1):154. doi: 10.1186/s12906-018-2218-5.

Protective Effect of Ganoderma Triterpenoids on Cadmium-Induced Testicular Toxicity in Chickens.
Wang H, Zhang R, Song Y, Li T, Ge M.
Biol Trace Elem Res. 2019 Jan;187(1):281-290. doi: 10.1007/s12011-018-1364-4. Epub 2018 May 2.

Purification, partial characterization and inducing tumor cell apoptosis activity of a polysaccharide from Ganoderma applanatum.
Zhen D, Su L, Miao Y, Zhao F, Ren G, Mahfuz S, Song H.
Int J Biol Macromol. 2018 Aug;115:10-17. doi: 10.1016/j.ijbiomac.2018.03.062. Epub 2018 Apr 10.
 
Triple helix conformation of β-d-glucan from Ganoderma lucidum and effect of molecular weight on its immunostimulatory activity.
Liu Y, Tang Q, Zhang J, Xia Y, Yang Y, Wu D, Fan H, Cui SW.
Int J Biol Macromol. 2018 Jul 15;114:1064-1070. doi: 10.1016/j.ijbiomac.2018.03.054. Epub 2018 Mar 13.
 
Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens.
Li R, Zhang L, Tang Z, Li T, Li G, Zhang R, Ge M.
Biol Trace Elem Res. 2019 Jan 10. doi: 10.1007/s12011-018-1627-0.
 
Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia.
Henao SLD, Urrego SA, Cano AM, Higuita EA.
Int J Med Mushrooms. 2018;20(8):705-716. doi: 10.1615/IntJMedMushrooms.2018026986.
 
Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis.
Zhao C, Fan J, Liu Y, Guo W, Cao H, Xiao J, Wang Y, Liu B.
Food Chem. 2019 Jan 15;271:148-156. doi: 10.1016/j.foodchem.2018.07.115. Epub 2018 Jul 18.
 
Role of Mushroom as Dietary Supplement on Performance of Poultry.
Khan SH, Mukhtar N, Iqbal J.
J Diet Suppl. 2018 Jul 3:1-14. doi: 10.1080/19390211.2018.1472707.
 
Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides.
Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X.
J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. eCollection 2018.
 
Protective properties of combined fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction.
Fan ST, Nie SP, Huang XJ, Wang S, Hu JL, Xie JH, Nie QX, Xie MY.
Int J Biol Macromol. 2018 Jul 15;114:1049-1055. doi: 10.1016/j.ijbiomac.2018.04.004. Epub 2018 Apr 4.
 
Effect of Ganoderma lucidum Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.
Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595. eCollection 2018.
 
Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.
Gurovic MSV, Viceconte FR, Pereyra MT, Bidegain MA, Cubitto MA.
J Ethnopharmacol. 2018 May 10;217:83-88. doi: 10.1016/j.jep.2018.02.005. Epub 2018 Feb 6.

Antitumor and Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.
Wang C, Shi S, Chen Q, Lin S, Wang R, Wang S, Chen C.
Integr Cancer Ther. 2018 Mar 1:1534735418762537. doi: 10.1177/1534735418762537. 

Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies.
Elkhateeb WA, Zaghlol GM, El-Garawani IM, Ahmed EF, Rateb ME, Abdel Moneim AE.
Biomed Pharmacother. 2018 Feb 26;101:264-277. doi: 10.1016/j.biopha.2018.02.058. 

Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi).
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Nat Prod Res. 2018 Feb 19:1-6. doi: 10.1080/14786419.2018.1440229.

DNA damaging potential of Ganoderma lucidum extracts.
Gurovic MSV, Viceconte FR, Pereyra MT, Bidegain MA, Cubitto MA.
J Ethnopharmacol. 2018 May 10;217:83-88. doi: 10.1016/j.jep.2018.02.005. Epub 2018 Feb 6.

A multi-center survey on dietary knowledge and behavior among inpatients in oncology department.
Cong M, Wang J, Fang Y, Liu Y, Sun M, Wu Q, Wang K, Huang Y, Ling Y, Liu Y, Li Q, Liu Y, Zhu J, Zhu L, Zheng Z, Li L, Liu D, Liu Z, Shi H, Yuan P.
Support Care Cancer. 2018 Feb 5. doi: 10.1007/s00520-018-4057-9.

Anticancer Activity of Ganoderic Acid DM: Current Status and Future Perspective.
Bryant JM, Bouchard M, Haque A.
J Clin Cell Immunol. 2017;8(6). pii: 535. doi: 10.4172/2155-9899.1000535. Epub 2017 Dec 12.

Anticancer effect of triterpenes from <i>Ganoderma lucidum</i> in human prostate cancer cells.
Qu L, Li S, Zhuo Y, Chen J, Qin X, Guo G.
Oncol Lett. 2017 Dec;14(6):7467-7472. doi: 10.3892/ol.2017.7153. Epub 2017 Oct 9.

New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense.
Bao F, Yang K, Wu C, Gao S, Wang P, Chen L, Li H.
Fitoterapia. 2018 Mar;125:123-129. doi: 10.1016/j.fitote.2018.01.001. Epub 2018 Jan 4.

<i>Ganoderma lucidum</i> polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway.
Yu Y, Qian L, Du N, Liu Y, Zhao X, Zhang X.
Exp Ther Med. 2017 Dec;14(6):5903-5907. doi: 10.3892/etm.2017.5340. Epub 2017 Oct 18.

The Efficacy and Toxicity of Using the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Its Products in Chemotherapy (Review).
Cizmarikova M.
Int J Med Mushrooms. 2017;19(10):861-877. doi: 10.1615/IntJMedMushrooms.2017024537.

Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells.
Huang SY, Chien CC, Hseu RS, Huang VYJ, Chiang SY, Huang CJ, Chen SK, Tsai RY, Lin HT, Cheng YC.
J Cell Biochem. 2017 Dec 14. doi: 10.1002/jcb.26616. 

Farnesyl phenolic enantiomers as natural MTH1 inhibitors from <i>Ganoderma sinense</i>.
Gao Y, Zhu L, Guo J, Yuan T, Wang L, Li H, Chen L.
Oncotarget. 2017 Sep 30;8(56):95865-95879. doi: 10.18632/oncotarget.21430. eCollection 2017 Nov 10.

Apoptosis induction of colorectal cancer cells HTL-9 in vitro by the transformed products of soybean isoflavones by Ganoderma lucidum.
Cui ML, Yang HY, He GQ.
J Zhejiang Univ Sci B. 2017 Dec.;18(12):1101-1112. doi: 10.1631/jzus.B1700189.

Isolation and Characterization of Lectin from the Artist's Conk Medicinal Mushroom, Ganoderma applanatum (Agaricomycetes), and Evaluation of Its Antiproliferative Activity in HT-29 Colon Cancer Cells.
Kumaran S, Pandurangan AK, Shenbhagaraman R, Esa NM.
Int J Med Mushrooms. 2017;19(8):675-684. doi: 10.1615/IntJMedMushrooms.2017021274.

Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada).
Smith A, Javed S, Barad A, Myhre V, Li WM, Reimer K, Massicotte HB, Tackaberry LE, Payne GW, Egger KN, Lee CH.
Int J Med Mushrooms. 2017;19(6):485-497. doi: 10.1615/IntJMedMushrooms.v19.i6.10.

The molecular basis of cytotoxicity of α-spinasterol from Ganoderma resinaceum: Induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines.
Sedky NK, El Gammal ZH, Wahba AE, Mosad E, Waly ZY, El-Fallal AA, Arafa RK, El-Badri N.
J Cell Biochem. 2018 May;119(5):3892-3902. doi: 10.1002/jcb.26515. Epub 2018 Jan 25.
 
Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.
Sohretoglu D, Huang S.
Anticancer Agents Med Chem. 2017 Nov 13. doi: 10.2174/1871520617666171113121246.

Ethyl lucidenates A reverses P-glycoprotein mediated vincristine resistance in K562/A02 cells.
Li P, Chen SY, Shen SX, Liu LX, Xu JH, Zhang ZQ.
Nat Prod Res. 2017 Nov 13:1-4. doi: 10.1080/14786419.2017.1402323.

Lanostane triterpenoids and ergostane-type steroids from the cultured mycelia of Ganoderma capense.
Tan Z, Zhao JL, Liu JM, Zhang M, Chen RD, Xie KB, Chen DW, Dai JG.
J Asian Nat Prod Res. 2017 Nov 9:1-8. doi: 10.1080/10286020.2017.1399879.

Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway.
Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, Li W.
Mol Med Rep. 2018 Jan;17(1):147-157. doi: 10.3892/mmr.2017.7904. Epub 2017 Oct 26.

Medicinal Mushrooms (PDQ®): Patient Version.
PDQ Integrative, Alternative, and Complementary Therapies Editorial Board.
PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-.
2017 Oct 24.

Molecular docking based screening of triterpenoids as potential G-quadruplex stabilizing ligands with anti-cancer activity.
Sillapapongwarakorn S, Yanarojana S, Pinthong D, Thithapandha A, Ungwitayatorn J, Supavilai P.
Bioinformation. 2017 Sep 30;13(9):284-292. doi: 10.6026/97320630013284. eCollection 2017.

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis.
Gill BS, Navgeet, Mehra R, Kumar V, Kumar S.
Invest New Drugs. 2018 Feb;36(1):136-143. doi: 10.1007/s10637-017-0526-0. Epub 2017 Oct 28. Review.

Overview of Ganoderma sinense polysaccharide-an adjunctive drug used during concurrent Chemo/Radiation therapy for cancer treatment in China.
Jiang Y, Chang Y, Liu Y, Zhang M, Luo H, Hao C, Zeng P, Sun Y, Wang H, Zhang L.
Biomed Pharmacother. 2017 Dec;96:865-870. doi: 10.1016/j.biopha.2017.09.060. Epub 2017 Nov 6. Review.

[Survival Benefit by Combined Administration of Cyclophosphamide, Lentinula edodes Mycelia Extract(LEM), and Ganoderma lucidum Mycelia Extract(MAK)in S1018B10 Tumor-Bearing Mice].
Sukegawa Y, Kawamura J, Okuno K.
Gan To Kagaku Ryoho. 2017 Oct;44(10):896-899. Japanese. 

GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition.
Wang TY, Yu CC, Hsieh PL, Liao YW, Yu CH, Chou MY.
Oncotarget. 2017 Jul 31;8(41):70422-70430. doi: 10.18632/oncotarget.19711. eCollection 2017 Sep 19.

The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo.
Li K, Na K, Sang T, Wu K, Wang Y, Wang X.
Oncol Rep. 2017 Nov;38(5):2803-2813. doi: 10.3892/or.2017.6010. Epub 2017 Sep 27.

Medicinal Mushrooms (PDQ®): Health Professional Version.
PDQ Integrative, Alternative, and Complementary Therapies Editorial Board.
PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-.
2017 Oct 6.

A review on phytochemistry and pharmacology of medicinal as well as poisonous mushrooms.
Sharma D, Singh VP, Singh NK.
Mini Rev Med Chem. 2017 Sep 27. doi: 10.2174/1389557517666170927144119. 

[Anti-tumor target prediction and activity verification of Ganoderma lucidum triterpenoids].
Du GH, Wang HX, Yan Z, Liu LY, Chen RY.
Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):517-522. doi: 10.19540/j.cnki.cjcmm.20161222.069. Chinese. 

Anti-inflammatory properties of GLPss58, a sulfated polysaccharide from Ganoderma lucidum.
Zhang K, Liu Y, Zhao X, Tang Q, Dernedde J, Zhang J, Fan H.
Int J Biol Macromol. 2018 Feb;107(Pt A):486-493. doi: 10.1016/j.ijbiomac.2017.09.015. Epub 2017 Sep 7.

Network pharmacology analysis of the anti-cancer pharmacological mechanisms of Ganoderma lucidum extract with experimental support using Hepa1-6-bearing C57 BL/6 mice.
Zhao RL, He YM.
J Ethnopharmacol. 2018 Jan 10;210:287-295. doi: 10.1016/j.jep.2017.08.041. Epub 2017 Sep 4.

Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum.
Huang SZ, Ma QY, Kong FD, Guo ZK, Cai CH, Hu LL, Zhou LM, Wang Q, Dai HF, Mei WL, Zhao YX.
Phytochemistry. 2017 Nov;143:104-110. doi: 10.1016/j.phytochem.2017.07.015. Epub 2017 Aug 8.

Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants.
Lukong KE, Ogunbolude Y, Kamdem JP.
Breast Cancer Res Treat. 2017 Nov;166(2):351-365. doi: 10.1007/s10549-017-4408-0. Epub 2017 Aug 4. Review.

<i>Ganoderma</i> spp.: A Promising Adjuvant Treatment for Breast Cancer.
Suárez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM.
Medicines (Basel). 2017 Mar;4(1). pii: 15. doi: 10.3390/medicines4010015. Epub 2017 Mar 15.

Apoptosis and anti-cancer drug discovery: the power of medicinal fungi and plants.
Wong JH, Cho Wing Sze S, Ng TB, Chi Fai Cheung R, Tam C, Zhang KY, Dan X, Chan YS, Chi Shing Cho W, Cheuk Wing Ng C, Miu Yee Waye M, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Yuen Sheung Ngan H, Sha O, Li G, Tse R, Tse TF, Chan H.
Curr Med Chem. 2017 Jul 20. doi: 10.2174/0929867324666170720165005.
 
Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer.
Yang Y, Nirmagustina DE, Kumrungsee T, Okazaki Y, Tomotake H, Kato N.
Biosci Biotechnol Biochem. 2017 Sep;81(9):1796-1804. doi: 10.1080/09168451.2017.1343117. Epub 2017 Jun 29.

Ganoderma lucidum targeting lung cancer signaling: A review.
Gill BS, Navgeet, Kumar S.
Tumour Biol. 2017 Jun;39(6):1010428317707437. doi: 10.1177/1010428317707437. Review.

Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling.
Zhang Y.
Biochem Biophys Res Commun. 2017 Jul 8;488(4):679-684. doi: 10.1016/j.bbrc.2017.04.086. Epub 2017 Apr 17.

The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis.
Son HU, Lee S, Heo JC, Lee SH.
Int J Mol Med. 2017 May;39(5):1233-1241. doi: 10.3892/ijmm.2017.2945. Epub 2017 Apr 7.

Screening and Analysis of the Marker Components in Ganoderma lucidum by HPLC and HPLC-MS<sup>n</sup> with the Aid of Chemometrics.
Wu L, Liang W, Chen W, Li S, Cui Y, Qi Q, Zhang L.
Molecules. 2017 Apr 6;22(4). pii: E584. doi: 10.3390/molecules22040584.

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo.
Na K, Li K, Sang T, Wu K, Wang Y, Wang X.
Int J Oncol. 2017 May;50(5):1541-1554. doi: 10.3892/ijo.2017.3939. Epub 2017 Mar 29.

Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer.
Gill BS, Kumar S, Navgeet.
Tumour Biol. 2017 Mar;39(3):1010428317695530. doi: 10.1177/1010428317695530.

Polysaccharide peptide isolated from grass-cultured <i>Ganoderma lucidum</i> induces anti-proliferative and pro-apoptotic effects in the human U251 glioma cell line.
Wang C, Lin D, Chen Q, Lin S, Shi S, Chen C.
Oncol Lett. 2018 Apr;15(4):4330-4336. doi: 10.3892/ol.2018.7823. Epub 2018 Jan 19.

Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.
Chi B, Wang S, Bi S, Qin W, Wu D, Luo Z, Gui S, Wang D, Yin X, Wang F.
Exp Ther Med. 2018 Jan;15(1):847-853. doi: 10.3892/etm.2017.5472. Epub 2017 Nov 8.

Anti-tumor and Anti-angiogenic Ergosterols from <i>Ganoderma lucidum</i>.
Chen S, Yong T, Zhang Y, Su J, Jiao C, Xie Y.
Front Chem. 2017 Oct 30;5:85. doi: 10.3389/fchem.2017.00085. eCollection 2017.

Potato freeze-thaw solution enhances immune function and antitumor activity in vivo.
Xu G, Shen J, Sun P, Niu Y, Zhao P, Tang P, Zhang J, Fei C, Bu L, Yue Z, Liu H, Wang Z, Yang L, Sun D.
Oncol Lett. 2017 Nov;14(5):6129-6134. doi: 10.3892/ol.2017.6970. Epub 2017 Sep 15.

Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α-glucosidase.
Chen B, Tian J, Zhang J, Wang K, Liu L, Yang B, Bao L, Liu H.
Fitoterapia. 2017 Jul;120:6-16. doi: 10.1016/j.fitote.2017.05.005. Epub 2017 May 17.

Effect of <i>Ganoderma lucidum</i> Powder on Oxidative Stability, Microbial and Sensory Properties of Emulsion Type Sausage.
Ghobadi R, Mohammadi R, Chabavizade J, Sami M.
Adv Biomed Res. 2018 Feb 16;7:24. doi: 10.4103/2277-9175.225595. eCollection 2018.

Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease.
Ma WW, Tao Y, Wang YY, Peng IF.
Chin J Nat Med. 2017 Dec;15(12):899-904. doi: 10.1016/S1875-5364(18)30005-0.

Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.
Kubota A, Kobayashi M, Sarashina S, Takeno R, Okamoto K, Narumi K, Furugen A, Suzuki Y, Takahashi N, Iseki K.
J Ethnopharmacol. 2018 Mar 25;214:240-243. doi: 10.1016/j.jep.2017.12.010. Epub 2017 Dec 14.

Ganoderma triterpenes retard renal cyst development by downregulating Ras/MAPK signaling and promoting cell differentiation.
Su L, Liu L, Jia Y, Lei L, Liu J, Zhu S, Zhou H, Chen R, Lu HAJ, Yang B.
Kidney Int. 2017 Dec;92(6):1404-1418. doi: 10.1016/j.kint.2017.04.013. Epub 2017 Jul 12.

Protective effect of Ganoderma lucidum polysaccharide against carbon tetrachloride-induced hepatic damage in precision-cut carp liver slices.
Liu Y, Zhang C, Du J, Jia R, Cao L, Jeney G, Teraoka H, Xu P, Yin G.
Fish Physiol Biochem. 2017 Oct;43(5):1209-1221. doi: 10.1007/s10695-016-0333-0. Epub 2017 Jul 5.

Nortriterpenoids from the Fruiting Bodies of the Mushroom Ganoderma resinaceum.
Chen XQ, Chen LX, Zhao J, Tang YP, Li SP.
Molecules. 2017 Jun 28;22(7). pii: E1073. doi: 10.3390/molecules22071073.

In Vitro Expression of Toll-Like Receptors and Proinflammatory Molecules Induced by Ergosta- 7,22-Dien-3-One Isolated from a Wild Mexican Strain of Ganoderma oerstedii (Agaricomycetes).
Ramos-Ligonio A, López-Monteon A, Lagunes-Castro MS, Suarez-Medellin J, Espinoza C, Mendoza G, Trigos A.
Int J Med Mushrooms. 2017;19(3):203-211. doi: 10.1615/IntJMedMushrooms.v19.i3.20.

Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.
Cai Q, Li Y, Pei G.
J Neuroinflammation. 2017 Mar 24;14(1):63. doi: 10.1186/s12974-017-0839-0.

Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum.
Carrieri R, Manco R, Sapio D, Iannaccone M, Fulgione A, Papaianni M, de Falco B, Grauso L, Tarantino P, Ianniello F, Lanzotti V, Lahoz E, Capparelli R.
Nat Prod Res. 2017 Sep;31(18):2119-2125. doi: 10.1080/14786419.2017.1278593. Epub 2017 Jan 20.

Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms.
Vetchinkina E, Shirokov A, Bucharskaya A, Navolokin N, Prilepskii A, Burov A, Maslyakova G, Nikitina VE.
Int J Med Mushrooms. 2016;18(11):955-964. doi: 10.1615/IntJMedMushrooms.v18.i11.10.

Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages.
Li WJ, Tang XF, Shuai XX, Jiang CJ, Liu X, Wang LF, Yao YF, Nie SP, Xie MY.
J Agric Food Chem. 2017 Jan 18;65(2):348-357. doi: 10.1021/acs.jafc.6b04888. Epub 2017 Jan 3.
 
Enhanced Release of Immunostimulating β-1,3- Glucan by Autodigestion of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Ishimoto Y, Ishibashi KI, Yamanaka D, Adachi Y, Ito H, Igami K, Miyazaki T, Ohno N.
Int J Med Mushrooms. 2017;19(1):1-16. doi: 10.1615/IntJMedMushrooms.v19.i1.10.

Medicinal Mushrooms (PDQ®): Health Professional Version.
PDQ Integrative, Alternative, and Complementary Therapies Editorial Board.  PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National 
Cancer Institute (US); 2002-. No abstract available.
2017 Mar 2.

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment.
Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C.
Nutrients. 2017 Feb 28;9(3). pii: E210. doi: 10.3390/nu9030210.

Sesquiterpenoids from the cultured mycelia of Ganoderma capense.
Tan Z, Zhao J, Liu J, Zhang M, Chen R, Xie K, Dai J.
Fitoterapia. 2017 Feb 21;118:73-79. doi: 10.1016/j.fitote.2017.02.007.

Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer.
Lin TY, Hsu HY, Sun WH, Wu TH, Tsao SM.
Int J Cancer. 2017 Feb 15. doi: 10.1002/ijc.30649

Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers.
Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK.
Pharm Biol. 2017 Dec;55(1):1041-1046. doi: 10.1080/13880209.2017.1288750.

Three new triterpenoids from Ganoderma theaecolum.
Liu LY, Yan Z, Kang J, Chen RY, Yu DQ.
J Asian Nat Prod Res. 2017 Feb 2:1-7. doi: 10.1080/10286020.2016.1271793

Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum.
Dai J, Miller MA, Everetts NJ, Wang X, Li P, Li Y, Xu JH, Yao G.
Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14634

A Summary of a Cochrane Review: Ganoderma lucidum (Reishi mushroom) for the treatment of cancer.
Santesso N, Wieland LS.
Eur J Integr Med. 2016 Oct;8(5):619-620. doi: 10.1016/j.eujim.2016.07.025. Epub 2016 Jul 20. No abstract available. 

Tubulin polymerization-stimulating activity of Ganoderma triterpenoids.
Kohno T, Hai-Bang T, Zhu Q, Amen Y, Sakamoto S, Tanaka H, Morimoto S, Shimizu K.
J Nat Med. 2017 Apr;71(2):457-462. doi: 10.1007/s11418-017-1072-y. Epub 2017 Jan 11.

Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors.
Amen Y, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Shimizu K.
J Nat Med. 2017 Apr;71(2):380-388. doi: 10.1007/s11418-016-1069-y. Epub 2017 Jan 10.

Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships.
Chen S, Li X, Yong T, Wang Z, Su J, Jiao C, Xie Y, Yang BB.
Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.

Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals.
Smina TP, Nitha B, Devasagayam TP, Janardhanan KK.
Mutat Res. 2017 Jan;813:45-51. doi: 10.1016/j.mrgentox.2016.11.010. Epub 2016 Dec 2.

In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor.
Suarez-Medellin J, Meza-Menchaca T, Carranza JA, Trigos A, Vidal-Limon AM.
Int J Med Mushrooms. 2016;18(11):1037-1047. doi: 10.1615/IntJMedMushrooms.v18.i11.80.

Antitumor Activity of Extracts from Medicinal Basidiomycetes Mushrooms.
Vetchinkina E, Shirokov A, Bucharskaya A, Navolokin N, Prilepskii A, Burov A, Maslyakova G, Nikitina VE.
Int J Med Mushrooms. 2016;18(11):955-964. doi: 10.1615/IntJMedMushrooms.v18.i11.10.

Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells.
Jiang D, Wang L, Zhao T, Zhang Z, Zhang R, Jin J, Cai Y, Wang F.
Oncol Rep. 2017 Jan;37(1):594-600. doi: 10.3892/or.2016.5246. Epub 2016 Nov 15.

Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis.
Tsao SM, Hsu HY.
Sci Rep. 2016 Nov 10;6:36563. doi: 10.1038/srep36563.

Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells.
Hsin IL, Wang SC, Li JR, Ciou TC, Wu CH, Wu HM, Ko JL.
Phytomedicine. 2016 Dec 1;23(13):1566-1573. doi: 10.1016/j.phymed.2016.09.003. Epub 2016 Sep 10.
 
Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum.
Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ.
Int J Mol Sci. 2016 Oct 27;17(11). pii: E1798.

New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense.
Li W, Lou LL, Zhu JY, Zhang JS, Liang AA, Bao JM, Tang GH, Yin S.
Fitoterapia. 2016 Dec;115:24-30. doi: 10.1016/j.fitote.2016.09.010. Epub 2016 Sep 28.

The anti-cancer components of <i>Ganoderma lucidum</i> possesses cardiovascular protective effect by regulating circular RNA expression.
Xie YZ, Yang F, Tan W, Li X, Jiao C, Huang R, Yang BB.
Oncoscience. 2016 Aug 28;3(7-8):203-207. eCollection 2016 Aug 28.

Ganoderma Lucidum (Reishi Mushroom) and cancer.
Unlu A, Nayir E, Kirca O, Ozdogan M.
J BUON. 2016 Jul-Aug;21(4):792-798. Review.

Sporoderm-Broken Spores of Ganoderma lucidum Inhibit the Growth of Lung Cancer: Involvement of the Akt/mTOR Signaling Pathway.
Chen Y, Lv J, Li K, Xu J, Li M, Zhang W, Pang X.
Nutr Cancer. 2016 Oct;68(7):1151-60. doi: 10.1080/01635581.2016.1208832. Epub 2016 Aug 11.

Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study.
Gill BS, Navgeet, Kumar S.
Tumour Biol. 2016 Oct;37(10):14271-14290. Epub 2016 Sep 3.

Colossolactone H, a new Ganoderma triterpenoid exhibits cytotoxicity and potentiates drug efficacy of gefitinib in lung cancer.
Chen SY, Chang CL, Chen TH, Chang YW, Lin SB.
Fitoterapia. 2016 Oct;114:81-91. doi: 10.1016/j.fitote.2016.08.015. Epub 2016 Aug 27.

Ganoderic Acid A Targeting β-Catenin in Wnt Signaling Pathway: In Silico and In Vitro Study.
Gill BS, Kumar S, Navgeet.
Interdiscip Sci. 2016 Aug 22.

A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed Autophagy and Triggered Apoptosis in Colorectal Cancer Cells.
Dan X, Liu W, Wong JH, Ng TB.
Front Pharmacol. 2016 Jul 25;7:217. doi: 10.3389/fphar.2016.00217. eCollection 2016 Jul 25.

Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity.
Lu CC, Hsu YJ, Chang CJ, Lin CS, Martel J, Ojcius DM, Ko YF, Lai HC, Young JD.
Innate Immun. 2016 Oct;22(7):522-33. doi: 10.1177/1753425916661402. Epub 2016 Jul 28.

Characterisation of a New Fungal Immunomodulatory Protein from Tiger Milk mushroom, Lignosus rhinocerotis.
Pushparajah V, Fatima A, Chong CH, Gambule TZ, Chan CJ, Ng ST, Tan CS, Fung SY, Lee SS, Tan NH, Lim RL.
Sci Rep. 2016 Jul 27;6:30010. doi: 10.1038/srep30010.

Triterpenes in cancer: significance and their influence.
Gill BS, Kumar S, Navgeet.
Mol Biol Rep. 2016 Sep;43(9):881-96. doi: 10.1007/s11033-016-4032-9. Epub 2016 Jun 25. Review.

Effect of exopolysaccharide from Ganoderma applanatum on the electrical properties of mouse fibroblast cells line L929 culture using an electric cell-substrate impedance sensing (ECIS) - Preliminary study.
Prendecka M, Mlak R, Jaszek M, Osińska-Jaroszuk M, Jakubiak-Hulicz M, Leibold C, Bieser A, Wójcik W, Małecka-Massalska T.
Ann Agric Environ Med. 2016 Jun 2;23(2):280-4. doi: 10.5604/12321966.1203891.

[Antitumor Effect of Ganoderma lipsiense Extract on Triple-negative Breast Cancer Model Mice and Mechanism Study].
Qi ZH, Meng J, Wang ZL, Sun HZ, Gong Y.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Mar;36(3):366-9. Chinese. 

Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum.
Shao Y, Qiao L, Wu L, Sun X, Zhu D, Yang G, Zhang X, Mao X, Chen W, Liang W, Zhang Y, Zhang L.
Molecules. 2016 May 21;21(5). pii: E678. doi: 10.3390/molecules21050678.

Ganoderma lucidum total triterpenes attenuate DLA induced ascites and EAC induced solid tumours in Swiss albino mice.
Smina TP, Mathew J, Janardhanan KK.
Cell Mol Biol (Noisy-le-grand). 2016 Apr 30;62(5):55-9.

A supercritical-CO2 extract of Ganoderma lucidum spores inhibits cholangiocarcinoma cell migration by reversing the epithelial-mesenchymal transition.
Li L, Guo HJ, Zhu LY, Zheng L, Liu X.
Phytomedicine. 2016 May 15;23(5):491-7. doi: 10.1016/j.phymed.2016.02.019. Epub 2016 Mar 3.

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells.
Li X, Wu Q, Bu M, Hu L, Du WW, Jiao C, Pan H, Sdiri M, Wu N, Xie Y, Yang BB.
Oncotarget. 2016 Jun 7;7(23):33948-59. doi: 10.18632/oncotarget.8608.

Ganoderma lucidum (Reishi mushroom) for cancer treatment.
Jin X, Ruiz Beguerie J, Sze DM, Chan GC.
Cochrane Database Syst Rev. 2016 Apr 5;4:CD007731. doi: 10.1002/14651858.CD007731.pub3. Review.

A proteomic analysis of mushroom polysaccharide-treated HepG2 cells.
Chai Y, Wang G, Fan L, Zhao M.
Sci Rep. 2016 Mar 29;6:23565. doi: 10.1038/srep23565.

Identification of Potential Anticancer Activities of Novel Ganoderma lucidum Extracts Using Gene Expression and Pathway Network Analysis.
Kao CH, Bishop KS, Xu Y, Han DY, Murray PM, Marlow GJ, Ferguson LR.
Genomics Insights. 2016 Feb 16;9:1-16. doi: 10.4137/GEI.S32477. eCollection 2016 Feb 16.

Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses.
Zhang J, Chen JM, Wang XX, Xia YM, Cui SW, Li J, Ding ZY.
Food Funct. 2016 Apr;7(4):1872-5. doi: 10.1039/c5fo01628b.

Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells.
Xu H, Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W, Zhou XW.
J Agric Food Chem. 2016 Apr 6;64(13):2690-8. doi: 10.1021/acs.jafc.6b00539. Epub 2016 Mar 24.

Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation.
Lin TY, Hsu HY.
Cancer Lett. 2016 Jun 1;375(2):340-8. doi: 10.1016/j.canlet.2016.03.018. Epub 2016 Mar 15.

Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression.
Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM.
J Cancer. 2016 Feb 5;7(5):500-11. doi: 10.7150/jca.13599. eCollection 2016 Feb 5.

Ganoderma lucidum total triterpenes prevent γ-radiation induced oxidative stress in Swiss albino mice in vivo.
Smina TP, Joseph J, Janardhanan KK.
Redox Rep. 2016 Nov;21(6):254-61. doi: 10.1080/13510002.2015.1126098. Epub 2016 Feb 5.

Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum.
Qiu J, Wang X, Song C.
Fitoterapia. 2016 Mar;109:75-9. doi: 10.1016/j.fitote.2015.12.008. Epub 2015 Dec 17.

Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response.
Cai Q, Li Y, Pei G.
J Neuroinflammation. 2017 Mar 24;14(1):63. doi: 10.1186/s12974-017-0839-0.

Screening and analysis of potential anti-tumor components from the stipe of Ganoderma sinense using high-performance liquid chromatography/time-of-flight mass spectrometry with multivariate statistical tool.
Chan KM, Yue GG, Li P, Wong EC, Lee JK, Kennelly EJ, Lau CB.
J Chromatogr A. 2017 Mar 3;1487:162-167. doi: 10.1016/j.chroma.2017.01.044. Epub 2017 Jan 22.

Structure and bioactivities of a polysaccharide isolated from Ganoderma lucidum in submerged fermentation.
Ai-Lati A, Liu S, Ji Z, Zhang H, Mao J.
Bioengineered. 2017 Jan 31:1-7. doi: 10.1080/21655979.2017.1283459. 

Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals.
Smina TP, Nitha B, Devasagayam TP, Janardhanan KK.
Mutat Res. 2017 Jan;813:45-51. doi: 10.1016/j.mrgentox.2016.11.010. Epub 2016 Dec 2.

Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum.
Li S, Zhao L, Xu W, Jiang Z, Kang J, Wang F, Xin F.
10.1371/journal.pone.0168436. eCollection 2016 Dec 20.

Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum.
Li WJ, Tang XF, Shuai XX, Jiang CJ, Liu X, Wang LF, Yao YF, Nie SP, Xie MY.
J Agric Food Chem. 2017 Jan 18;65(2):348-357. doi: 10.1021/acs.jafc.6b04888. Epub 2017 Jan 3.

Antitumor effects and mechanisms of <i>Ganoderma</i> extracts and spores oil.
Chen C, Li P, Li Y, Yao G, Xu JH.
Oncol Lett. 2016 Nov;12(5):3571-3578. Epub 2016 Aug 29.

Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi.
Wang XL, Ding ZY, Liu GQ, Yang H, Zhou GY.
Molecules. 2016 Oct 20;21(10). pii: E1395.

Effects of the polysaccharides extracted from Ganoderma lucidum on chemotherapy-related fatigue in mice.
Ouyang MZ, Lin LZ, Lv WJ, Zuo Q, Lv Z, Guan JS, Wang ST, Sun LL, Chen HR, Xiao ZW.
Int J Biol Macromol. 2016 Oct;91:905-10. doi: 10.1016/j.ijbiomac.2016.04.084. Epub 2016 May 18.

Antimicrobial Properties and Cytotoxicity of Sulfated (1,3)-β-D-Glucan from the Mycelium of the Mushroom Ganoderma lucidum.
Wan-Mohtar WA, Young L, Abbott GM, Clements C, Harvey LM, McNeil B.
J Microbiol Biotechnol. 2016 Jun 28;26(6):999-1010. doi: 10.4014/jmb.1510.10018.

Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom).
Saylam Kurtipek G, Ataseven A, Kurtipek E, Kucukosmanoglu İ, Toksoz MR.
Dermatol Ther (Heidelb). 2016 Mar;6(1):105-9. doi: 10.1007/s13555-016-0099-4. Epub 2016 Feb 11.

Structural data and immunomodulatory properties of a water-soluble heteroglycan extracted from the mycelium of an Italian isolate of Ganoderma lucidum.
Carrieri R, Manco R, Sapio D, Iannaccone M, Fulgione A, Papaianni M, de Falco B, Grauso L, Tarantino P, Ianniello F, Lanzotti V, Lahoz E, Capparelli R.
Nat Prod Res. 2017 Jan 20:1-7. doi: 10.1080/14786419.2017.1278593. 

Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging.
Zeng Q, Zhou F, Lei L, Chen J, Lu J, Zhou J, Cao K, Gao L, Xia F, Ding S, Huang L, Xiang H, Wang J, Xiao Y, Xiao R, Huang J.
Mol Med Rep. 2017 Jan;15(1):111-116. doi: 10.3892/mmr.2016.6026. Epub 2016 Dec 12.

Ganoderma atrum polysaccharide ameliorates ROS generation and apoptosis in spleen and thymus of immunosuppressed mice.
Li WJ, Li L, Zhen WY, Wang LF, Pan M, Lv JQ, Wang F, Yao YF, Nie SP, Xie MY.
Food Chem Toxicol. 2017 Jan;99:199-208. doi: 10.1016/j.fct.2016.11.033. Epub 2016 Nov 30.

Comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells.
Zhu N, Lv X, Wang Y, Li J, Liu Y, Lu W, Yang L, Zhao J, Wang F, Zhang LW.
Int J Biol Macromol. 2016 Dec;93(Pt A):940-951. doi: 10.1016/j.ijbiomac.2016.09.064.

Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B₁.
Liu T, Ma Q, Zhao L, Jia R, Zhang J, Ji C, Wang X.
Toxins (Basel). 2016 Sep 24;8(10). pii: E278. doi: 10.3390/toxins8100278.

Ganoderma lucidum polysaccharides encapsulated in liposome as an adjuvant to promote Th1-bias immune response.
Liu Z, Xing J, Zheng S, Bo R, Luo L, Huang Y, Niu Y, Li Z, Wang D, Hu Y, Liu J, Wu Y.
Carbohydr Polym. 2016 May 20;142:141-8. doi: 10.1016/j.carbpol.2016.01.021. Epub 2016 Jan 12.

Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies.
Yurkiv B, Wasser SP, Nevo E, Sybirna NO.
Int J Med Mushrooms. 2015;17(10):943-55.

Determination of nucleosides in Cordyceps sinensis and Ganoderma lucidum by high performance liquid chromatography method.
Khan MS, Parveen R, Mishra K, Tulsawani R, Ahmad S.
J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):264-6. doi: 10.4103/0975-7406.168022.

Ganoderma: insights into anticancer effects.
Kladar NV, Gavarić NS, Božin BN.
Eur J Cancer Prev. 2016 Sep;25(5):462-71. doi: 10.1097/CEJ.0000000000000204.

The Effect of Agaricus brasiliensis and Ganoderma lucidum Medicinal Mushroom Administration on the L-arginine/Nitric Oxide System and Rat Leukocyte Apoptosis in Experimental Type 1 Diabetes Mellitus.
Yurkiv B, Wasser SP, Nevo E, Sybirna NO.
Int J Med Mushrooms. 2015;17(4):339-50.

Two new triterpenoids from fruiting bodies of fungus Ganoderma lucidum.
Zhao ZZ, Yin RH, Chen HP, Feng T, Li ZH, Dong ZJ, Cui BK, Liu JK
J Asian Nat Prod Res. 2015 Jan 29:1-6.[Epub ahead of print]

Ganoderma lucidum for Cancer Treatment: We Are Close but Still Not There.
Cheng S, Sliva D.
Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review.

Cytokine production suppression by culture supernatant of B16F10 cells and amelioration by Ganoderma lucidum polysaccharides in activated lymphocytes.
Cheng S, Sliva D.
Integr Cancer Ther. 2015 Jan 27. pii: 1534735414568721. [Epub ahead of print] Review.

Khz (Fusion Product of Ganoderma lucidum and Polyporus umbellatus Mycelia) Induces Apoptosis in Human Colon Carcinoma HCT116 Cells, Accompanied by an Increase in Reactive Oxygen Species, Activation of Caspase 3, and Increased Intracellular Ca(2+).
Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.
J Med Food. 2015 Mar;18(3):332-6. doi: 10.1089/jmf.2013.3135. Epub 2014 Dec 9.

Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities.
Ferreira IC, Heleno SA, Reis FS, Stojkovic D, Queiroz MJ, Vasconcelos MH, Sokovic M.
Phytochemistry. 2014 Nov 5. pii: S0031-9422(14)00415-4. doi: 10.1016/j.phytochem.2014.10.011. [Epub ahead of print] Review.

Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43.
Dai S, Liu J, Sun X, Wang N.
BMC Complement Altern Med. 2014 Nov 5;14:434. doi: 10.1186/1472-6882-14-434.

A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp.
Xia Q, Zhang H, Sun X, Zhao H, Wu L, Zhu D, Yang G, Shao Y, Zhang X, Mao X, Zhang L, She G.
Molecules. 2014 Oct 30;19(11):17478-535. doi: 10.3390/molecules191117478.

Fungal beta glucan protects radiation induced DNA damage in human lymphocytes.
Pillai TG, Maurya DK, Salvi VP, Janardhanan KK, Nair CK.
Ann Transl Med. 2014 Feb;2(2):13. doi: 10.3978/j.issn.2305-5839.2014.02.02.

Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes).
Gupta A, Kirar V, Keshri GK, Gola S, Yadav A, Negi PS, Misra K.
Int J Med Mushrooms. 2014;16(4):345-54.

CARI III inhibits tumor growth in a melanoma-bearing mouse model through induction of G0/G1 cell cycle arrest.
Park HJ.
Molecules. 2014 Sep 12;19(9):14383-95. doi: 10.3390/molecules190914383.

A comparative study on immunomodulatory activity of polysaccharides from two official species of Ganoderma (Lingzhi).
Meng LZ, Xie J, Lv GP, Hu DJ, Zhao J, Duan JA, Li SP.
Nutr Cancer. 2014;66(7):1124-31. doi: 10.1080/01635581.2014.948215. Epub 2014 Sep 10.

Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice.
Wang CL, Lu CY, Hsueh YC, Liu WH, Chen CJ.
Appl Microbiol Biotechnol. 2014 Nov;98(22):9389-98. doi: 10.1007/s00253-014-6027-6. Epub 2014 Sep 2.

Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential.
Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC.
Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review.

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.
Wong KL, Wong RN, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PC, Lai YM, Zhang ZJ, Zhang Y, Tong Y, Cheung HP, Lu J, Sze SC.
Chin Med. 2014 Jul 19;9:19. doi: 10.1186/1749-8546-9-19. eCollection 2014. Review.

A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells.
Sun Z, Huang K, Fu X, Zhou Z, Cui Y, Li H.
Tumour Biol. 2014 Oct;35(10):9919-26. doi: 10.1007/s13277-014-2217-1. Epub 2014 Jul 6.

Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) on transformed cells by human papillomavirus.
Hernández-Márquez E, Lagunas-Martínez A, Bermudez-Morales VH, Burgete-García AI, León-Rivera I, Montiel-Arcos E, García-Villa E, Gariglio P, Madrid-Marina V V, Ondarza-Vidaurreta RN.
Int J Med Mushrooms. 2014;16(2):179-87.

A green chemistry approach for synthesizing biocompatible gold nanoparticles.
Gurunathan S, Han J, Park JH, Kim JH.
Nanoscale Res Lett. 2014 May 21;9(1):248. doi: 10.1186/1556-276X-9-248. eCollection 2014.

Ganoderma lucidum polysaccharides target a Fas/caspase dependent pathway to induce apoptosis in human colon cancer cells.
Liang Z, Guo YT, Yi YJ, Wang RC, Hu QL, Xiong XY.
Asian Pac J Cancer Prev. 2014;15(9):3981-6.

Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi.
Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R.
Asian Pac J Cancer Prev. 2014;15(10):4193-6.

FIP-gts potentiate autophagic cell death against cisplatin-resistant urothelial cancer cells.
Li JR, Cheng CL, Yang WJ, Yang CR, Ou YC, Wu MJ, Ko JL.
Anticancer Res. 2014 Jun;34(6):2973-83.

A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle.
Oliveira M, Reis FS, Sousa D, Tavares C, Lima RT, Ferreira IC, dos Santos T, Vasconcelos MH.
Food Funct. 2014 Jul 25;5(7):1389-94. doi: 10.1039/c4fo00258j.

Biological activity of Ganoderma lucidum basidiocarps cultivated on alternative and commercial substrate.
Cilerdžić J, Vukojević J, Stajić M, Stanojković T, Glamočlija J.
J Ethnopharmacol. 2014 Aug 8;155(1):312-9. doi: 10.1016/j.jep.2014.05.036. Epub 2014 May 29.

Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X.
Int J Mol Sci. 2014 May 22;15(5):9103-16. doi: 10.3390/ijms15059103.

The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro.
Hahne JC, Meyer SR, Dietl J, Honig A.
Int J Oncol. 2014 Jul;45(1):373-82. doi: 10.3892/ijo.2014.2414. Epub 2014 May 5.

An in vitro evaluation of graphene oxide reduced by Ganoderma spp. in human breast cancer cells (MDA-MB-231).
Gurunathan S, Han J, Park JH, Kim JH.
Int J Nanomedicine. 2014 Apr 8;9:1783-97. doi: 10.2147/IJN.S57735. eCollection 2014.

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes.
Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H, Sliva D.
Int J Oncol. 2014 Jun;44(6):2009-15. doi: 10.3892/ijo.2014.2375. Epub 2014 Apr 9.

The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.
Lin J, Chang YJ, Yang WB, Yu AL, Wong CH.
PLoS One. 2014 Apr 4;9(4):e94040. doi: 10.1371/journal.pone.0094040. eCollection 2014.

Ganoderma atrum polysaccharide evokes antitumor activity via cAMP-PKA mediated apoptotic pathway and down-regulation of Ca(2+)/PKC signal pathway.
Zhang S, Nie S, Huang D, Huang J, Feng Y, Xie M.
Food Chem Toxicol. 2014 Jun;68:239-46. doi: 10.1016/j.fct.2014.03.020. Epub 2014 Apr 2.

A novel polysaccharide from Ganoderma atrum exerts antitumor activity by activating mitochondria-mediated apoptotic pathway and boosting the immune system.
Zhang S, Nie S, Huang D, Feng Y, Xie M.
J Agric Food Chem. 2014 Feb 19;62(7):1581-9. doi: 10.1021/jf4053012. Epub 2014 Feb 7.

Cytokine production suppression by culture supernatant of B16F10 cells and amelioration by Ganoderma lucidum polysaccharides in activated lymphocytes.
Sun LX, Li WD, Lin ZB, Duan XS, Xing EH, Jiang MM, Yang N, Qi HH, Sun Y, Li M, Niu YD, Lu J.
Cell Tissue Res. 2015 Jan 15. [Epub ahead of print]

A high throughput colorimetric assay of β-1,3-D-glucans by Congo red dye.
Semedo MC, Karmali A, Fonseca L.
J Microbiol Methods. 2015 Feb;109:140-8. doi: 10.1016/j.mimet.2014.12.020. Epub 2014 Dec 31.

Toll-like receptor 4 mediates the antitumor host response induced by Ganoderma atrum polysaccharide.
Yu Q, Nie SP, Wang JQ, Huang DF, Li WJ, Xie MY.
J Agric Food Chem. 2015 Jan 21;63(2):517-25. doi: 10.1021/jf5041096. Epub 2015 Jan 9.

Ganoderma lucidum polysaccharide exerts anti-tumor activity via MAPK pathways in HL-60 acute leukemia cells.
Yang G, Yang L, Zhuang Y, Qian X, Shen Y.
J Recept Signal Transduct Res. 2014 Oct 20:1-8. [Epub ahead of print]

Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.
Zhang W, Zhang Q, Deng W, Li Y, Xing G, Shi X, Du Y.
Neural Regen Res. 2014 Aug 1;9(15):1446-52. doi: 10.4103/1673-5374.139461.

Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.
Choi S, Nguyen VT, Tae N, Lee S, Ryoo S, Min BS, Lee JH.
Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42. doi: 10.1016/j.taap.2014.09.007. Epub 2014 Sep 16.

A polysaccharide from Ganoderma atrum inhibits tumor growth by induction of apoptosis and activation of immune response in CT26-bearing mice.
Zhang S, Nie S, Huang D, Huang J, Feng Y, Xie M.
J Agric Food Chem. 2014 Sep 24;62(38):9296-304. doi: 10.1021/jf503250d. Epub 2014 Sep 11.

Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties.
Osińska-Jaroszuk M, Jaszek M, Mizerska-Dudka M, Błachowicz A, Rejczak TP, Janusz G, Wydrych J, Polak J, Jarosz-Wilkołazka A, Kandefer-Szerszeń M.
Biomed Res Int. 2014;2014:743812. doi: 10.1155/2014/743812. Epub 2014 Jul 10.

Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17.
Habijanic J, Berovic M, Boh B, Plankl M, Wraber B.
N Biotechnol. 2015 Jan 25;32(1):85-95. doi: 10.1016/j.nbt.2014.07.007. Epub 2014 Jul 29.

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.
Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS.
BMC Complement Altern Med. 2014 Jul 10;14:236. doi: 10.1186/1472-6882-14-236.

Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection.
Zhang W, Tao J, Yang X, Yang Z, Zhang L, Liu H, Wu K, Wu J.
Biochem Biophys Res Commun. 2014 Jul 4;449(3):307-12. doi: 10.1016/j.bbrc.2014.05.019. Epub 2014 May 15.

The Effect of Mushroom Beta-Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis.
Chen SN, Chang CS, Hung MH, Chen S, Wang W, Tai CJ, Lu CL.
Evid Based Complement Alternat Med. 2014;2014:252171. doi: 10.1155/2014/252171. Epub 2014 Apr 1.

Production and functional characterization of a novel fungal immunomodulatory protein FIP-SN15 shuffled from two genes of Ganoderma species.
Cong WR, Xu H, Liu Y, Li QZ, Li W, Zhou XW.
Appl Microbiol Biotechnol. 2014 Jul;98(13):5967-75. doi: 10.1007/s00253-014-5539-4. Epub 2014 Feb 28.

Suppression of the production of transforming growth factor β1, interleukin-10, and vascular endothelial growth factor in the B16F10 cells by Ganoderma lucidum polysaccharides.
Sun LX, Lin ZB, Duan XS, Qi HH, Yang N, Li M, Xing EH, Sun Y, Yu M, Li WD, Lu J.
J Interferon Cytokine Res. 2014 Sep;34(9):667-75. doi: 10.1089/jir.2012.0101. Epub 2014 Mar 27.

Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 β and TNF- α , Oxidative Stress, and NF- κ B Activation in Ovalbumin-Induced Asthmatic Mice.
Min-Chang G, Wei-Hong T, Zhen X, Jie S.
Evid Based Complement Alternat Med. 2014;2014:182817. doi: 10.1155/2014/182817. Epub 2014 Feb 10.

Acetylation and carboxymethylation of the polysaccharide from Ganoderma atrum and their antioxidant and immunomodulating activities.
Chen Y, Zhang H, Wang Y, Nie S, Li C, Xie M.
Food Chem. 2014 Aug 1;156:279-88. doi: 10.1016/j.foodchem.2014.01.111. Epub 2014 Feb 7.

Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides.
Wang J, Zhang Y, Yuan Y, Yue T.
Food Chem Toxicol. 2014 Jun;68:183-9. doi: 10.1016/j.fct.2014.03.003. Epub 2014 Mar 10.

Anti-inflammatory and hepatoprotective effects of Ganoderma lucidum polysaccharides on carbon tetrachloride-induced hepatocyte damage in common carp (Cyprinus carpio L.).
Liu YJ, Du JL, Cao LP, Jia R, Shen YJ, Zhao CY, Xu P, Yin GJ.
Int Immunopharmacol. 2015 Mar;25(1):112-20. doi: 10.1016/j.intimp.2015.01.023. Epub 2015 Jan 29.

Ganoderma formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma.
Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ.
Springerplus. 2014 Jun 12;3:297. doi: 10.1186/2193-1801-3-297. eCollection 2014.

Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.
Zhou Y, Chen S, Ding R, Yao W, Gao X.
Mediators Inflamm. 2014;2014:691285. doi: 10.1155/2014/691285. Epub 2014 May 22.

Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum.
Bhardwaj N, Katyal P, Sharma AK.
Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17.

Extraction of polysaccharide from Ganoderma lucidum and its immune enhancement activity.
Huang SQ, Ning ZX.
Int J Biol Macromol. 2010 Oct 1;47(3):336-41.

GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response.
Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, Reutter W, Fan H.
Life Sci. 2010 Sep 30.

Preparation, characterisation and anti-tumour activity of Ganoderma lucidum polysaccharide nanoparticles.
Li N, Hu YL, He CX, Hu CJ, Zhou J, Tang GP, Gao JQ.
J Pharm Pharmacol. 2010 Jan;62(1):139-44.

Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes.
Yeh CH, Chen HC, Yang JJ, Chuang WI, Sheu F.
J Agric Food Chem. 2010 Aug 11;58(15):8535-44.

Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells.
Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, Choi YH.
J Acupunct Meridian Stud. 2010 Mar;3(1):24-31.

The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells.
Cheng CH, Leung AY, Chen CF.
Nutr Cancer. 2010 Jul;62(5):648-58.

Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK).
Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, Sliva D.
Nutr Cancer. 2010 Jul;62(5):630-40.

A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas.
Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, Chayama K.
Hiroshima J Med Sci. 2010 Mar;59(1):1-6.

Optimization of alkaline extraction of polysaccharides from Ganoderma lucidum and their effect on immune function in mice.
Huang SQ, Li JW, Wang Z, Pan HX, Chen JX, Ning ZX.
Molecules. 2010 May 25;15(5):3694-708.

In vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages.
Lee SH, Lillehoj HS, Hong YH, Jang SI, Lillehoj EP, Ionescu C, Mazuranok L, Bravo D.
Br Poult Sci. 2010 Apr;51(2):213-21.

The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis.
Weng CJ, Yen GC.
Clin Exp Metastasis. 2010 May;27(5):361-9.

Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study.
Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K, Yoshimura K, Habuchi T, Fukushima M.
Int J Urol. 2010 Jun;17(6):548-54.

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression.
Chen NH, Liu JW, Zhong JJ.
Pharmacol Rep. 2010 Jan-Feb;62(1):150-63.

Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.
Dev Cell. 2010 Mar 16;18(3):486-95.

Cytokines expression induced by Ganoderma sinensis fungal immunomodulatory proteins (FIP-gsi) in mouse spleen cells.
Li Q, Wang X, Chen Y, Lin J, Zhou X.
Appl Biochem Biotechnol. 2010 Nov;162(5):1403-13.

Medicinal mushroom Ganoderma lucidum (Leyss: Fr) Karst. triggers immunomodulatory effects and reduces nitric oxide synthesis in mice.
Rubel R, Dalla Santa HS, Bonatto SJ, Bello S, Fernandes LC, Di Bernardi R, Gern J, Santos CA, Soccol CR.
J Med Food. 2010 Feb;13(1):142-8.

Ganoderma lucidum induced apoptosis in NB4 human leukemia cells: involvement of Akt and Erk.
Calviño E, Manjón JL, Sancho P, Tejedor MC, Herráez A, Diez JC.
J Ethnopharmacol. 2010 Mar 2;128(1):71-8.

Supplements for immune enhancement in hematologic malignancies.
Sze DM, Chan GC.
Hematology Am Soc Hematol Educ Program. 2009:313-9. Review.

Ganoderma lucidum extracts inhibited leukemia WEHI-3 cells in BALB/c mice and promoted an immune response in vivo.
Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, Ho CC, Wood WG, Chung JG.
Biosci Biotechnol Biochem. 2009 Dec;73(12):2589-94..

Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?
Volman JJ, Helsper JP, Wei S, Baars JJ, van Griensven LJ, Sonnenberg AS, Mensink RP, Plat J.
Mol Nutr Food Res. 2010 Feb;54(2):268-76.

Enhancement of antitumor activities in sulfated and carboxymethylated polysaccharides of Ganoderma lucidum.
Wang J, Zhang L, Yu Y, Cheung PC.
J Agric Food Chem. 2009 Nov 25;57(22):10565-72.

Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.
Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL, Wong CH.
J Biol Chem. 2009 Dec 11;284(50):34479-89.

An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways.
Lin YL, Liang YC, Tseng YS, Huang HY, Chou SY, Hseu RS, Huang CT, Chiang BL.
J Leukoc Biol. 2009 Oct;86(4):877-89.

The effect of a novel botanical agent TBS-101 on invasive prostate cancer in animal models.
Evans S, Dizeyi N, Abrahamsson PA, Persson J.
Anticancer Res. 2009 Oct;29(10):3917-24.

Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.
Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD.
Nutr Cancer. 2009;61(5):696-707.

[Effects of medicinal insect Catharsius molossus on submerged fermentation and in vivo anti-hepatoma activity of Ganoderma lucidum]
Liu G, Ding C, Zhang K, Wang X.
Sheng Wu Gong Cheng Xue Bao. 2009 Jun;25(6):880-6.

Complementary therapies, herbs, and other OTC agents: Reishi mushroom.
Cassileth B.
Oncology (Williston Park). 2009 Jul;23(8):728.

Enteric mucosal immune response might trigger the immunomodulation activity of Ganoderma lucidum polysaccharide in mice.
Zhao H, Luo Y, Lu C, Lin N, Xiao C, Guan S, Guo DA, Liu Z, Ju D, He X, Lu A.
Planta Med. 2010 Feb;76(3):223-7.

Ganoderma lucidum Polysaccharides Induce Macrophage-like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation.
Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF.
Evid Based Complement Alternat Med. 2009 Aug 20.

Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum.
Shang D, Zhang J, Wen L, Li Y, Cui Q.
J Agric Food Chem. 2009 Sep 9;57(17):7737-42.

Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum.
Dudhgaonkar S, Thyagarajan A, Sliva D.
Int Immunopharmacol. 2009 Oct;9(11):1272-80. .

Ganoderma lucidum immunomodulatory protein(Lz-8) expressed in Pichia pastoris and the identification of immunocompetence.
Liang C, Zhang S, Liu Z, Sun F.
Sheng Wu Gong Cheng Xue Bao. 2009 Mar;25(3):441-7.

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration Through Inhibition of Microglial Activation.
Zhang R, Xu S, Cai Y, Zhou M, Zuo X, Chan P.
Evid Based Complement Alternat Med. 2009 Jul 16.

Ganoderma lucidum induces the expression of CD40/CD86 on peripheral blood monocytes.
Ahmadi K, Riazipour M.
Iran J Immunol. 2009 Jun;6(2):87-91.

Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum.
Guo L, Xie J, Ruan Y, Zhou L, Zhu H, Yun X, Jiang Y, Lü L, Chen K, Min Z, Wen Y, Gu J.
Int Immunopharmacol. 2009 Sep;9(10):1175-82.
[Effect of Ganoderma lucidum polysaccharides on intestinal mucosal immune system in H22 liver cancer bearing mice]
Zhou GQ, Zhao HY, Lu C.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):335-9.

Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia of ganoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells.
Chen YK, Kuo YH, Chiang BH, Lo JM, Sheen LY.
J Agric Food Chem. 2009 Jul 8;57(13):5713-9.

Inhibitory effects of ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in cells and animal models.
Weng CJ, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD.
J Agric Food Chem. 2009 Jun 10;57(11):5049-57.

Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines.
Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP.
J Agric Food Chem. 2009 Apr 22;57(8):3087-93.

Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo.
Hsu SC, Ou CC, Chuang TC, Li JW, Lee YJ, Wang V, Liu JY, Chen CS, Lin SC, Kao MC.
Cancer Lett. 2009 Aug 18;281(1):108-16.

Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7.

Anti-androgen effects of extracts and compounds from Ganoderma lucidum.
Liu J, Tamura S, Kurashiki K, Shimizu K, Noda K, Konishi F, Kumamoto S, Kondo R.
Chem Biodivers. 2009 Feb;6(2):231-43.

[Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle]
Li L, Li T, Wang XJ, Xu JP, Wang SG.
Zhong Yao Cai. 2008 Oct;31(10):1514-8.

Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells.
Sadava D, Still DW, Mudry RR, Kane SE.
Cancer Lett. 2009 May 18;277(2):182-9.

Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy.
Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, Tseng HC, Lee HS, Huang MC, Shane GT, Yang CH, Shen YC, Yan YY, Wang CK.
Phytother Res. 2009 Jun;23(6):785-90.

Lipid extract from completely sporoderm-broken germinating Ganoderma sinensis spores elicits potent antitumor immune responses in human macrophages.
Zhang JP, Zheng L, Wang JH, Magnusson KE, Liu X.
Phytother Res. 2009 Jun;23(6):844-50.

Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum.
Mahajna J, Dotan N, Zaidman BZ, Petrova RD, Wasser SP.
Nutr Cancer. 2009;61(1):16-26.

Therapeutic potential of various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in cancer therapy.
Driscoll M, Hansen R, Ding C, Cramer DE, Yan J.
Cancer Biol Ther. 2009 Feb;8(3):218-25.

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
Miyamoto I, Liu J, Shimizu K, Sato M, Kukita A, Kukita T, Kondo R.
Eur J Pharmacol. 2009 Jan 5;602(1):1-7.

Chinese herbs (Astragalus radix and Ganoderma lucidum) enhance immune response of carp, Cyprinus carpio, and protection against Aeromonas hydrophila.
Yin G, Ardó L, Thompson KD, Adams A, Jeney Z, Jeney G.
Fish Shellfish Immunol. 2009 Jan;26(1):140-5.

Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest.
Hsu SC, Ou CC, Li JW, Chuang TC, Kuo HP, Liu JY, Chen CS, Lin SC, Su CH, Kao MC.
J Ethnopharmacol. 2008 Dec 8;120(3):394-401.

Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression.
Chen NH, Liu JW, Zhong JJ.
J Pharmacol Sci. 2008 Oct;108(2):212-6.

The signaling cascades of Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in human neuroblastoma SH-SY5Y cell lines.
Pinweha S, Wanikiat P, Sanvarinda Y, Supavilai P.
Neurosci Lett. 2008 Dec 19;448(1):62-6.

Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity.
Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T, Nakata Y.
Biol Pharm Bull. 2008 Oct;31(10):1933-7.

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum.
Guan SH, Xia JM, Yang M, Wang XM, Liu X, Guo DA.
J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):705-10.

Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low".
Zhang Y, Lin Z, Hu Y, Wang F.
Br J Sports Med. 2008 Oct;42(10):819-22.

Serum amyloid A mediates the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion to endothelial cells.
Li YB, Wang R, Wu HL, Li YH, Zhong LJ, Yu HM, Li XJ.
Oncol Rep. 2008 Sep;20(3):549-56.

Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells.
Jeurink PV, Noguera CL, Savelkoul HF, Wichers HJ.
Int Immunopharmacol. 2008 Aug;8(8):1124-33.

Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function.
Chan WK, Cheung CC, Law HK, Lau YL, Chan GC.
J Hematol Oncol. 2008 Jul 21;1:9.

Toxicity of a traditional Chinese medicine, Ganoderma lucidum, in children with cancer.
Gill SK, Rieder MJ.
Can J Clin Pharmacol. 2008 Summer;15(2):e275-85.

Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice.
Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S.
Biosci Biotechnol Biochem. 2008 Jun;72(6):1399-408. Epub 2008 Jun 7.

Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells.
Hsu HY, Hua KF, Wu WC, Hsu J, Weng ST, Lin TL, Liu CY, Hseu RS, Huang CT.
J Cell Physiol. 2008 Apr;215(1):15-26.

Effects of fermentation products of Ganoderma lucidum on growth performance and immunocompetence in weanling pigs.
Chen SD, Hsieh MC, Chiou MT, Lai YS, Cheng YH.
Arch Anim Nutr. 2008 Feb;62(1):22-32.

[Preparation and biological properties of basidiomycete aqueous extracts and their mycelial compositions]
Bukhman VM, Treshchalina EM, Krasnopol'skaia LM, Isakova EB, Sedakova LA, Avtonomova AV, Leont'eva MI, Soboleva NIu, Belitskiĭ IV, Bakanov AV.
Antibiot Khimioter. 2007;52(1-2):4-9.

Telomerase-associated apoptotic events by mushroom ganoderma lucidum on premalignant human urothelial cells.
Yuen JW, Gohel MD, Au DW.
Nutr Cancer. 2008;60(1):109-19.

Reversal effect of Ganoderma lucidum polysaccharide on multidrug resistance in K562/ADM cell line.
Li WD, Zhang BD, Wei R, Liu JH, Lin ZB.
Acta Pharmacol Sin. 2008 May;29(5):620-7.

Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.
Jiang J, Grieb B, Thyagarajan A, Sliva D.
Int J Mol Med. 2008 May;21(5):577-84.

Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity.
Jeong YT, Yang BK, Jeong SC, Kim SM, Song CH.
Phytother Res. 2008 May;22(5):614-9.

Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae.
Liao CH, Hsiao YM, Lin CH, Yeh CS, Wang JC, Ni CH, Hsu CP, Ko JL.
Food Chem Toxicol. 2008 May;46(5):1851-9. Epub 2008 Feb 2.

[Changes of serum interferon-gamma levels in mice bearing S-180 tumor and the interventional effect of immunomodulators]
Li L, Lei LS, Yu CL.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):65-8.

Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidum.
Ma C, Guan SH, Yang M, Liu X, Guo DA.
Phytomedicine. 2008 Apr;15(4):268-76.

Extracellular expression of a functional recombinant Ganoderma lucidium immunomodulatory protein by Bacillus subtilis and Lactococcus lactis.
Yeh CM, Yeh CK, Hsu XY, Luo QM, Lin MY.
Appl Environ Microbiol. 2008 Feb;74(4):1039-49. .

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC.
Carcinogenesis. 2008 Jan;29(1):147-56.

Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.
Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF.
BMC Genomics. 2007 Nov 9;8:411.

Potential of a novel polysaccharide preparation (GLPP) from Anhui-grown Ganoderma lucidum in tumor treatment and immunostimulation.
Pang X, Chen Z, Gao X, Liu W, Slavin M, Yao W, Yu LL.
J Food Sci. 2007 Aug;72(6):S435-42.

The immune effects of edible fungus polysaccharides compounds in mice.
Yin Y, Fu W, Fu M, He G, Traore L.
Asia Pac J Clin Nutr. 2007;16 Suppl 1:258-60.

The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain.
Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC.
Mol Nutr Food Res. 2007 Dec;51(12):1472-7.

Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats.
Wang X, Zhao X, Li D, Lou YQ, Lin ZB, Zhang GL.
Biol Pharm Bull. 2007 Sep;30(9):1702-6.

Two new lanostanoids from Ganoderma resinaceum.
Niu XM, Li SH, Xiao WL, Sun HD, Che CT.
J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):659-64.

Human nonmetastatic clone 23 type 1 gene suppresses migration of cervical cancer cells and enhances the migration inhibition of fungal immunomodulatory protein from Ganoderma tsugae.
Wang PH, Yang SF, Chen GD, Han CP, Chen SC, Lin LY, Ko JL.
Reprod Sci. 2007 Jul;14(5):475-85.

Ganoderma lucidum and its pharmaceutically active compounds.
Boh B, Berovic M, Zhang J, Zhi-Bin L.
Biotechnol Annu Rev. 2007;13:265-301.

Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells.
Zaidman BZ, Wasser SP, Nevo E, Mahajna J.
Int J Oncol. 2007 Oct;31(4):959-67.

Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae.
Liao CH, Hsiao YM, Sheu GT, Chang JT, Wang PH, Wu MF, Shieh GJ, Hsu CP, Ko JL.
Biochem Pharmacol. 2007 Nov 15;74(10):1541-54.

Ganodermataceae: natural products and their related pharmacological functions.
Zhou X, Lin J, Yin Y, Zhao J, Sun X, Tang K.
Am J Chin Med. 2007;35(4):559-74. .

[Effect of Ganoderma lucidum polysaccharides on tumor cell nucleotide content and cell cycle in S180 ascitic tumor-bearing mice]
Li JJ, Lei LS, Yu CL, Zhu ZG, Zhang Q, Wu SG.
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jul;27(7):1003-5.

Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae.
Ko HH, Hung CF, Wang JP, Lin CN.
Phytochemistry. 2008 Jan;69(1):234-9.

The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.
Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R.
Bioorg Med Chem. 2007 Jul 15;15(14):4966-72.

Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)?
Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M.
Int J Surg Pathol. 2007 Apr;15(2):180-6.

Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo.
Wang G, Zhao J, Liu J, Huang Y, Zhong JJ, Tang W.
Int Immunopharmacol. 2007 Jun;7(6):864-70.

Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells.
Zaidman BZ, Wasser SP, Nevo E, Mahajna J.
Mol Biol Rep. 2008 Jun;35(2):107-17.

Ganoderma lucidum: a cause of pseudoparasitosis.
Wanachiwanawin D, Piankijagum A, Chaiprasert A, Lertlaituan P, Tungtrongchitr A, Chinabutr P.
Southeast Asian J Trop Med Public Health. 2006 Nov;37(6):1099-102.

Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells.
Thyagarajan A, Zhu J, Sliva D.
Int J Oncol. 2007 Apr;30(4):963-9.

Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.
Ko KM, Leung HY.
Chin Med. 2007 Mar 27;2:3.

Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum.
Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y.
Chem Biodivers. 2007 Feb;4(2):224-31.

Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice.
Zhu XL, Chen AF, Lin ZB.
J Ethnopharmacol. 2007 May 4;111(2):219-26.

[Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy]
Wang DH, Weng XC.
Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(19):1618-22.

Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model.
Lin JY, Chen ML, Lin BF.
Food Chem Toxicol. 2006 Dec;44(12):2025-32.

Antiproliferative ability of a combination regimen of crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute myelogenous leukemia.
Chui CH, Wong RS, Cheng GY, Lau FY, Kok SH, Cheng CH, Cheung F, Tang WK, Teo IT, Chan AS, Tang JC.
Oncol Rep. 2006 Dec;16(6):1313-6.

Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats.
Kashimoto N, Hayama M, Kamiya K, Watanabe H.
Oncol Rep. 2006 Dec;16(6):1181-7.

Comparative studies of various ganoderma species and their different parts with regard to their antitumor and immunomodulating activities in vitro.
Yue GG, Fung KP, Tse GM, Leung PC, Lau CB.
J Altern Complement Med. 2006 Oct;12(8):777-89.

Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ.
Life Sci. 2006 Dec 23;80(3):205-11.

Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion.
Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D.
Int J Mol Med. 2006 Oct;18(4):657-64.

Anti-tumor activities of the antlered form of Ganoderma lucidum in allogeneic and syngeneic tumor-bearing mice.
Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T, Yamaguchi H, Abe S.
Biosci Biotechnol Biochem. 2006 Sep;70(9):2028-34.

Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling.
Jiang J, Slivova V, Sliva D.
Int J Oncol. 2006 Sep;29(3):695-703.

Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1.
Lin KI, Kao YY, Kuo HK, Yang WB, Chou A, Lin HH, Yu AL, Wong CH.
J Biol Chem. 2006 Aug 25;281(34):24111-23.

Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice.
Lin YL, Lee SS, Hou SM, Chiang BL.
Mol Pharmacol. 2006 Aug;70(2):637-44.

[Ganoderma polysaccharides antagonize prostaglandin E2-induced suppression of murine splenocyte IFN-gamma and TNF-alpha mRNA expression]
Zhang Q, Lei LS, Zhu ZG, Yu CL, Wu SG.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jun;26(6):780-3.

Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells.
Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB.
Life Sci. 2006 Aug 15;79(12):1129-39.

Ganoderma lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells.
Xie JT, Wang CZ, Wicks S, Yin JJ, Kong J, Li J, Li YC, Yuan CS.
Exp Oncol. 2006 Mar;28(1):25-9.

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and Duchesnea chrysantha extracts.
Kim KC, Kim JS, Son JK, Kim IG.
Cancer Lett. 2007 Feb 8;246(1-2):210-7.

Anti-hepatitis activities in the broth of Ganoderma lucidum supplemented with a Chinese herbal medicine.
Li Y, Yang Y, Fang L, Zhang Z, Jin J, Zhang K.
Am J Chin Med. 2006;34(2):341-9.

In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury.
Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH.
World J Gastroenterol. 2006 Mar 7;12(9):1379-85.

Ganoderma lucidum in cancer research.
Sliva D.
Leuk Res. 2006 Jul;30(7):767-8.

Pharmacological and anti-tumor activities of ganoderma spores processed by top-down approaches.
Liu X, Wang JH, Yuan JP.
J Nanosci Nanotechnol. 2005 Dec;5(12):2001-13.

Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer.
Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC, Duan W, Yang HY, Zhu YZ, Zhou SF.
Int Immunopharmacol. 2006 Mar;6(3):499-508.

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
Müller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, Koeffler HP.
Leuk Res. 2006 Jul;30(7):841-8..

Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line.
Liao CH, Hsiao YM, Hsu CP, Lin MY, Wang JC, Huang YL, Ko JL.
Mol Carcinog. 2006 Apr;45(4):220-9.

Ganoderma lucidum mycelia enhance innate immunity by activating NF-kappaB.
Kuo MC, Weng CY, Ha CL, Wu MJ.
J Ethnopharmacol. 2006 Jan 16;103(2):217-22.

101.Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy.
Chan WK, Lam DT, Law HK, Wong WT, Koo MW, Lau AS, Lau YL, Chan GC.
J Altern Complement Med. 2005 Dec;11(6):1047-57.

[Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]
Wang PY, Wang SZ, Lin SQ, Lin ZB.
Beijing Da Xue Xue Bao. 2005 Dec 18;37(6):569-74.

Medicinal mushroom cuts off prostate cancer cells' blood supply.
Johnston N.
Drug Discov Today. 2005 Dec;10(23-24):1584.

Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus.
Campos Ziegenbein F, Hanssen HP, König WA.
Phytochemistry. 2006 Jan;67(2):202-11.

Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell.
Cao QZ, Lin ZB.
Life Sci. 2006 Feb 23;78(13):1457-63.

Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum.
Lin ZB.
J Pharmacol Sci. 2005 Oct;99(2):144-53.

[Luminous quack doctor]
[No authors listed]
Praxis (Bern 1994). 2005 Sep 21;94(38):1497.

[Application of flow cytometry on functional assessment of health food]
Yang XF, Huang Q, Huang JM, Li Z, Cai M, Huang JK, Chen BF.
Zhonghua Yu Fang Yi Xue Za Zhi. 2005 Sep;39(5):335-41.

Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer.
Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, Chan E, Koh HL, Li X, Zhou S.
J Med Food. 2005 Summer;8(2):159-68.

Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells.
Zhu XL, Lin ZB.
Acta Pharmacol Sin. 2005 Sep;26(9):1130-7.

Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402.
Yang HL.
Biotechnol Lett. 2005 Jun;27(12):835-8.

[Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides]
Jiang Y, Wang H, Lü L, Tian GY.
Yao Xue Xue Bao. 2005 Apr;40(4):347-50. Chinese.

A quantum chemical and statistical study of ganoderic acids with cytotoxicity against tumor cell.
Yang HL, Chen GH, Li YQ.
Eur J Med Chem. 2005 Oct;40(10):972-6. Epub 2005 Jul 11.

Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice.
Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu C, Zhou S.
Immunol Invest. 2005;34(2):171-98.

Formulation and in vitro/in vivo evaluation of combining DNA repair and immune enhancing nutritional supplements.
Pero RW, Amiri A, Sheng Y, Welther M, Rich M.
Phytomedicine. 2005 Apr;12(4):255-63.

Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways.
Lin YL, Liang YC, Lee SS, Chiang BL.
J Leukoc Biol. 2005 Aug;78(2):533-43.

Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells.
Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS, Lin SB.
Life Sci. 2005 Jun 3;77(3):252-65.

New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants.
Kimura Y.
In Vivo. 2005 Jan-Feb;19(1):37-60.

Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells.
Stanley G, Harvey K, Slivova V, Jiang J, Sliva D.
Biochem Biophys Res Commun. 2005 Apr 29;330(1):46-52.

Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes.
Gu YH, Belury MA.
Cancer Lett. 2005 Mar 18;220(1):21-8.

Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons
from hypoxia/reoxygenation injury.
Zhao HB, Wang SZ, He QH, Yuan L, Chen AF, Lin ZB.
Life Sci. 2005 Jan 14;76(9):1027-37.

[Progress in research on Ganoderma lucidium spore]
Zhang W, Zeng YS.
Zhong Xi Yi Jie He Xue Bao. 2004 Nov;2(6):463-5.

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms.
Lin ZB, Zhang HN.
Acta Pharmacol Sin. 2004 Nov;25(11):1387-95.

Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro.
Lu QY, Jin YS, Zhang Q, Zhang Z, Heber D, Go VL, Li FP, Rao JY.
Cancer Lett. 2004 Dec 8;216(1):9-20.

Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling.
Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D.
Nutr Cancer. 2004;49(2):209-16.

Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood.
Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH, Chang HY, Hsieh JF, Wong CH, Chen ST.
Bioorg Med Chem. 2004 Nov 1;12(21):5603-9.

Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides.
Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH.
Bioorg Med Chem. 2004 Nov 1;12(21):5595-601.

Immune receptors for polysaccharides from Ganoderma lucidum.
Shao BM, Dai H, Xu W, Lin ZB, Gao XM.
Biochem Biophys Res Commun. 2004 Oct 8;323(1):133-41.

Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro.
Lu QY, Sartippour MR, Brooks MN, Zhang Q, Hardy M, Go VL, Li FP, Heber D.
Oncol Rep. 2004 Sep;12(3):659-62.

Medicinal mushroom extracts inhibit ras-induced cell transformation and the inhibitory effect requires the presence of normal cells.
Hsiao WL, Li YQ, Lee TL, Li N, You MM, Chang ST.
Carcinogenesis. 2004 Jul;25(7):1177-83.

[Activation of mouse macrophages by the alkali-extracted polysaccharide from spore of Ganoderma lucidum]
Tang QJ, Zhang JS, Pan YJ, Reutter W, Fan H.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Mar;20(2):142-4.

Immunomodulatory and antimicrobial effects of some traditional chinese medicinal herbs: a review.
Tan BK, Vanitha J.
Curr Med Chem. 2004 Jun;11(11):1423-30.

Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide.
Cao QZ, Lin ZB.
Acta Pharmacol Sin. 2004 Jun;25(6):833-8.

Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines.
Tomasi S, Lohézic-Le Dévéhat F, Sauleau P, Bézivin C, Boustie J.
Pharmazie. 2004 Apr;59(4):290-3.

Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.
Jiang J, Slivova V, Valachovicova T, Harvey K, Sliva D.
Int J Oncol. 2004 May;24(5):1093-9.

Biologically active compounds from Aphyllophorales (polypore) fungi.
Zjawiony JK.
J Nat Prod. 2004 Feb;67(2):300-10.

Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer.
deVere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B.
Urology. 2004 Feb;63(2):259-63.

A mushroom (Ganoderma capense) lectin with spectacular thermostability, potent mitogenic activity on splenocytes, and antiproliferative activity toward tumor cells.
Ngai PH, Ng TB.
Biochem Biophys Res Commun. 2004 Feb 20;314(4):988-93.

Ganoderma lucidum (Reishi) in cancer treatment.
Sliva D.
Integr Cancer Ther. 2003 Dec;2(4):358-64.

Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum.
Song YS, Kim SH, Sa JH, Jin C, Lim CJ, Park EH.
J Ethnopharmacol. 2004 Jan;90(1):17-20.

Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T, Nomura A, Nishino H.
J Nat Prod. 2003 Dec;66(12):1582-5.

Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells.
Sliva D, Sedlak M, Slivova V, Valachovicova T, Lloyd FP Jr, Ho NW.
J Altern Complement Med. 2003 Aug;9(4):491-7.

Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients.
Gao Y, Zhou S, Jiang W, Huang M, Dai X.
Immunol Invest. 2003 Aug;32(3):201-15.

Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.
Shiao MS.
Chem Rec. 2003;3(3):172-80.

Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides.
Berovic M, Habijanic J, Zore I, Wraber B, Hodzar D, Boh B, Pohleven F.
J Biotechnol. 2003 Jun 12;103(1):77-86.

Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum.
Hsu MJ, Lee SS, Lee ST, Lin WW.
Br J Pharmacol. 2003 May;139(2):289-98.

Synthesis of beta-(1-->6)-branched beta-(1-->3) glucohexaose and its analogues containing an alpha-(1-->3) linked bond with antitumor activity.
Ning J, Zhang W, Yi Y, Yang G, Wu Z, Yi J, Kong F.
Bioorg Med Chem. 2003 May 15;11(10):2193-203.

Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro.
Cao LZ, Lin ZB.
Acta Pharmacol Sin. 2003 Apr;24(4):321-6.

Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest.
Lin SB, Li CH, Lee SS, Kan LS.
Life Sci. 2003 Apr 11;72(21):2381-90.

Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity.
Miura T, Yuan L, Sun B, Fujii H, Yoshida M, Wakame K, Kosuna K.
Biosci Biotechnol Biochem. 2002 Dec;66(12):2626-31.

A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats.
Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H.
Oncol Rep. 2003 Mar-Apr;10(2):375-9.

[Isolation, purification and bioactivities of exopoly saccharides from fermented broth of Ganoderma lucidum]
Li P, Zhang K.
Wei Sheng Wu Xue Bao. 2000 Apr;40(2):217-20.

Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance.
Kimura Y, Taniguchi M, Baba K.
Anticancer Res. 2002 Nov-Dec;22(6A):3309-18.

Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat.
Gao Y, Zhou S, Wen J, Huang M, Xu A.
Life Sci. 2002 Dec 27;72(6):731-45.

Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells.
Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd FP Jr, Ho NW.
Biochem Biophys Res Commun. 2002 Nov 8;298(4):603-12.

Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell.
Hu H, Ahn NS, Yang X, Lee YS, Kang KS.
Int J Cancer. 2002 Nov 20;102(3):250-3.

Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharides.
Cao LZ, Lin ZB.
Immunol Lett. 2002 Oct 1;83(3):163-9.

Regression of prostate cancer following administration of Genistein Combined Polysaccharide (GCP), a nutritional supplement: a case report.
Ghafar MA, Golliday E, Bingham J, Mansukhani MM, Anastasiadis AG, Katz AE.
J Altern Complement Med. 2002 Aug;8(4):493-7.

Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway.
Hsu MJ, Lee SS, Lin WW.
J Leukoc Biol. 2002 Jul;72(1):207-16.

Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum.
Liu X, Yuan JP, Chung CK, Chen XJ.
Cancer Lett. 2002 Aug 28;182(2):155-61.

Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice.
Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB.
World J Gastroenterol. 2002 Aug;8(4):728-33

New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells.
Gao JJ, Min BS, Ahn EM, Nakamura N, Lee HK, Hattori M.
Chem Pharm Bull (Tokyo). 2002 Jun;50(6):837-40.

New lanostanoids from the fungus Ganoderma concinna.
González AG, León F, Rivera A, Padrón JI, González-Plata J, Zuluaga JC, Quintana J, Estévez F, Bermejo J.
J Nat Prod. 2002 Mar;65(3):417-21.

Mechanism of action of herbal supplement PC-SPES: elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells.
Hsieh TC, Wu JM.
Int J Oncol. 2002 Mar;20(3):583-8.

Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA.
Shi YL, James AE, Benzie IF, Buswell JA.
Teratog Carcinog Mutagen. 2002;22(2):103-11.

Prevention of development of N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice.
Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H.
Int J Mol Med. 2002 Feb;9(2):113-7.

Structural features of immunologically active polysaccharides from Ganoderma lucidum.
Bao XF, Wang XS, Dong Q, Fang JN, Li XY.
Phytochemistry. 2002 Jan;59(2):175-81.

[Study on antitumor activity and mechanism of Ganoderma polysaccharides B]
Zhang Q, Lin Z.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Sep;19(9):544-7.

Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats.
Lu H, Uesaka T, Katoh O, Kyo E, Watanabe H.
Oncol Rep. 2001 Nov-Dec;8(6):1341-5.

Effects of polysaccharides (FI0-c) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (II).
Gao XX, Wang BX, Fei XF, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.
Acta Pharmacol Sin. 2000 Dec;21(12):1186-92.

Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I).
Gao XX, Fei XF, Wang BX, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T.
Acta Pharmacol Sin. 2000 Dec;21(12):1179-85.

Cytotoxicity of Ganoderma lucidum triterpenes.
Wu TS, Shi LS, Kuo SC.
J Nat Prod. 2001 Aug;64(8):1121-2.

Solution properties of antitumor sulfated derivative of alpha-(1-->3)-D-glucan from Ganoderma lucidum.
Zhang L, Zhang M, Zhou Q, Chen J, Zeng F.
Biosci Biotechnol Biochem. 2000 Oct;64(10):2172-8.

Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells.
Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY.
FEBS Lett. 2000 Dec 15;486(3):291-6.

New lanostanoids from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured hepalcic7 murine hepatoma cells.
Ha TB, Gerhäuser C, Zhang WD, Ho-Chong-Line N, Fourasté I.
Planta Med. 2000 Oct;66(7):681-4.

Role of herbal compounds (PC-SPES) in hormone-refractory prostate cancer: two case reports.
de la Taille A, Hayek OR, Burchardt M, Burchardt T, Katz AE.
J Altern Complement Med. 2000 Oct;6(5):449-51.

Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells.
Zhu HS, Yang XL, Wang LB, Zhao DX, Chen L.
Cell Biol Toxicol. 2000;16(3):201-6.

Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.
Min BS, Gao JJ, Nakamura N, Hattori M.
Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1026-33.

Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation.
Kim KC, Kim IG.
Int J Mol Med. 1999 Sep;4(3):273-7.

New lanostanoids of Ganoderma tsugae.
Su HJ, Fann YF, Chung MI, Won SJ, Lin CN.
J Nat Prod. 2000 Apr;63(4):514-6.

Update from Asia. Asian studies on cancer chemoprevention.
Yun TK.
Ann N Y Acad Sci. 1999;889:157-92. Review.

Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective.
Wasser SP, Weis AL.
Crit Rev Immunol. 1999;19(1):65-96

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).
Kim HS, Kacew S, Lee BM.
Carcinogenesis. 1999 Aug;20(8):1637-40.

Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle.
Gan KH, Fann YF, Hsu SH, Kuo KW, Lin CN.
J Nat Prod. 1998 Apr;61(4):485-7.

Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea.
Hsu HC, Hsu CI, Lin RH, Kao CL, Lin JY.
Biochem J. 1997 Apr 15;323 ( Pt 2):557-65.

The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes.
Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK.
Int J Cancer. 1997 Mar 17;70(6):699-705.

[Psychoneuroimmunological effects of morphine and the immunoprotection of Ganoderma polysaccharides peptide in morphine-dependent mice]
Lu ZW.
Sheng Li Ke Xue Jin Zhan. 1995 Jan;26(1):45-9.

Trial of a new medium-term model using benzo(a)pyrene induced lung tumor in newborn mice.
Yun TK, Kim SH, Lee YS.
Anticancer Res. 1995 May-Jun;15(3):839-45.

Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium.
Zhang J, Wang G, Li H, Zhuang C, Mizuno T, Ito H, Mayuzumi H, Okamoto H, Li J.
Biosci Biotechnol Biochem. 1994 Jul;58(7):1202-5.

[Testing of plant extracts preparations for prevention and non-toxic therapy of oncologic diseases in experimental models]
Bocharova OA, Serebriakova RV.
Vestn Ross Akad Med Nauk. 1994;(2):52-5.

[Effects of Ganoderma polysaccharides on the activity of DNA polymerase alpha of splenocytes and immune function in aged mice]
Lei LS, Lin ZB.
Yao Xue Xue Bao. 1993;28(8):577-82.

The lack of antiplatelet effect of crude extracts from ganoderma lucidum on HIV-positive hemophiliacs.
Gau JP, Lin CK, Lee SS, Wang SR.
Am J Chin Med. 1990;18(3-4):175-9.

Ling Zhi-8: a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression.
Haak-Frendscho M, Kino K, Sone T, Jardieu P.
Cell Immunol. 1993 Aug;150(1):101-13.

Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae.
Wang G, Zhang J, Mizuno T, Zhuang C, Ito H, Mayuzumi H, Okamoto H, Li J.
Biosci Biotechnol Biochem. 1993 Jun;57(6):894-900.

The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells.
Lieu CW, Lee SS, Wang SY.
Anticancer Res. 1992 Jul-Aug;12(4):1211-5.

[Chemical studies on immunologically active polysaccharides of Ganoderma lucidum(Leyss. ex Fr.) Karst]
He Y, Li R, Chen Q, Lin Z, Xia D, Ma L.
Zhongguo Zhong Yao Za Zhi. 1992 Apr;17(4):226-8, 256.

Novel cytotoxic principles of Formosan Ganoderma lucidum.
Lin CN, Tome WP, Won SJ.
J Nat Prod. 1991 Jul-Aug;54(4):998-1002.

[In vitro cytotoxicity of Ganoderma lucidum on oral cancer cells]
Chen TW, Wong YK, Lee SS.
Zhonghua Yi Xue Za Zhi (Taipei). 1991 Jul;48(1):54-8.

Evidence for cross-reactive allergens among basidiomycetes: immunoprint-inhibition studies.
De Zubiria A, Horner WE, Lehrer SB.
J Allergy Clin Immunol. 1990 Jul;86(1):26-33.

Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst.
Maruyama H, Yamazaki K, Murofushi S, Konda C, Ikekawa T.
J Pharmacobiodyn. 1989 Feb;12(2):118-23.

[Effect of six edible plants on the development of AFB1-induced gamma-glutamyltranspeptidase-positive hepatocyte foci in rats]
Chen ZY, Yan RQ, Qin GZ, Qin LL.
Zhonghua Zhong Liu Za Zhi. 1987 Mar;9(2):109-11.

Human sensitization to Ganoderma antigen.
Tarlo SM, Bell B, Srinivasan J, Dolovich J, Hargreave FE.
J Allergy Clin Immunol. 1979 Jul;64(1):43-9.

Effect of polysaccharides from Ganoderma applanatum on immune responses. I. Enhancing effect on the induction of delayed hypersensitivity in mice.
Nakashima S, Umeda Y, Kanada T.
Microbiol Immunol. 1979;23(6):501-13.

Antitumor polysaccharides from some polyporaceae, Ganoderma applanatum (Pers.) Pat and Phellinus linteus (Berk. et Curt) Aoshima.
Sasaki T, Arai Y, Ikekawa T, Chihara G, Fukuoka F.
Chem Pharm Bull (Tokyo). 1971 Apr;19(4):821-6.

Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells.
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GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells.
Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH, Ko JL.
Autophagy. 2011 Aug 1;7(8).

Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.
Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T.
Biochem Biophys Res Commun. 2011 Mar 29.

Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaidTM: Mechanism of activity.
Jiang J, Eliaz I, Sliva D.
Int J Oncol. 2011 Apr 4. doi: 10.3892/ijo.2011.996.
Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin.

Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C.
Int J Oncol. 2011 May;38(5):1319-27. doi: 10.3892/ijo.2011.965. Epub 2011 Mar 8.

Enhancement of Cyclophosphamide-Induced Antitumor Effect by a Novel Polysaccharide from Ganoderma atrum in Sarcoma 180-Bearing Mice.
Li W, Nie S, Chen Y, Wang Y, Li C, Xie M.
J Agric Food Chem. 2011 Mar 22.

Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells.
Ma J, Liu C, Chen Y, Jiang J, Qin Z.
Cell Biochem Funct. 2011 Apr;29(3):175-82. doi: 10.1002/cbf.1735. Epub 2011 Feb 24.

Ergosta-7,22-diene-2β,3α,9α-triol from the Fruit Bodies of Ganoderma lucidum Induces Apoptosis in Human Myelocytic HL-60 Cells.
Lee MK, Hung TM, Cuong TD, Na M, Kim JC, Kim EJ, Park HS, Choi JS, Lee I, Bae K, Hattori M, Min BS.
Phytother Res. 2011 Mar 11. doi: 10.1002/ptr.3447.

Ganoderma atrum polysaccharide induces anti-tumor activity via the mitochondrial apoptotic pathway related to activation of host immune response.
Li WJ, Chen Y, Nie SP, Xie MY, He M, Zhang SS, Zhu KX.
J Cell Biochem. 2011 Mar;112(3):860-71. doi: 10.1002/jcb.22993.

Determination of Trace Elements in Anti-influenza Virus Mushrooms.
Wang L, Hou Y.
Biol Trace Elem Res. 2011 Feb 8.
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